Effect of Mechanical Stretch on the DNCB-induced Proinflammatory Cytokine Secretion in Human Keratinocytes

Skin is exposed to various physico-chemical cues. Keratinocytes, a major component of the skin epidermis, directly interact with the surrounding extracellular matrix, and thus, biochemical and biophysical stimulations from the matrix regulate the function of keratinocytes. Although it was reported t...

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Veröffentlicht in:	Scientific reports 2019-03, Vol.9 (1), p.5156, Article 5156
Hauptverfasser:	Oh, Seunghee, Chung, Hyewon, Chang, Sooho, Lee, Su-Hyon, Seok, Seung Hyeok, Lee, Hyungsuk
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Chloro-2,4-dinitrobenzene 13/21 13/62 38/1 631/57 631/80 Actin Adhesion Animals Cell Line Cell morphology Cell Nucleus Shape - drug effects Cell Shape - drug effects Cell size Chemical stimuli Cytokines Cytokines - metabolism Cytology Cytoskeleton Dinitrochlorobenzene - pharmacology Epidermis Extracellular matrix Humanities and Social Sciences Humans Inflammation Inflammation Mediators - metabolism Interleukin 6 Intracellular signalling Keratinocytes Keratinocytes - drug effects Keratinocytes - metabolism Mechanical stimuli Mice, Inbred C57BL Models, Biological multidisciplinary Science Science (multidisciplinary) Signal Transduction - drug effects Skin Stress, Mechanical Structural analysis Vinculin - metabolism
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