Adult outcomes of childhood disruptive disorders in offspring of depressed and healthy parents
•Childhood disruptive disorders are associated with poor prognosis in adulthood.•Whether parental psychopathology is driving this association is unclear.•We find that even in the absence of familial risk, prognosis is poor.•Children with disruptive disorders grow up to have more depression and subst...
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| Veröffentlicht in: | Journal of affective disorders 2019-02, Vol.244, p.107-112 |
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| creator | Diaz, Alexandre Paim Svob, Connie Zhao, Ruixin DiFabrizio, Baxter Warner, Virginia Gameroff, Marc J. Skipper, Jamie Gingrich, Jay Posner, Jonathan Wickramaratne, Priya J. Weissman, Myrna M. Talati, Ardesheer |
| description | •Childhood disruptive disorders are associated with poor prognosis in adulthood.•Whether parental psychopathology is driving this association is unclear.•We find that even in the absence of familial risk, prognosis is poor.•Children with disruptive disorders grow up to have more depression and substance use.•However in the absence of parental ASPD they do not develop ASPD.
Longitudinal studies of children with disruptive disorders (DDs) have shown high rates of antisocial personality disorder (ASPD) and substance use in adulthood, but few have examined the contribution of parental disorders. We examine child-/adulthood outcomes of DDs in offspring, whose biological parents did not have a history of ASPD, bipolar disorder, or substance use disorders.
Offspring (N = 267) of parents with or without major depression (MDD), but no ASPD or bipolar disorders were followed longitudinally over 33 years, and associations between DDs and psychiatric and functional outcomes were tested.
Eighty-nine (33%) offspring had a DD. Those with, compared to without DDs, had higher rates of MDD (adjusted odds ratio, AOR = 3.42, p |
| doi_str_mv | 10.1016/j.jad.2018.10.086 |
| format | Article |
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Longitudinal studies of children with disruptive disorders (DDs) have shown high rates of antisocial personality disorder (ASPD) and substance use in adulthood, but few have examined the contribution of parental disorders. We examine child-/adulthood outcomes of DDs in offspring, whose biological parents did not have a history of ASPD, bipolar disorder, or substance use disorders.
Offspring (N = 267) of parents with or without major depression (MDD), but no ASPD or bipolar disorders were followed longitudinally over 33 years, and associations between DDs and psychiatric and functional outcomes were tested.
Eighty-nine (33%) offspring had a DD. Those with, compared to without DDs, had higher rates of MDD (adjusted odds ratio, AOR = 3.42, p < 0.0001), bipolar disorder (AOR = 3.10, p = 0.03), and substance use disorders (AOR = 5.69, p < 0.0001) by age 18, as well as poorer school performance and global functioning. DDs continued to predict MDD and substance use outcomes in adulthood, even after accounting for presence of the corresponding disorder in childhood (MDD: hazards ratio, HR = 3.25, p < 0.0001; SUD, HR = 2.52, p < 0.0001). Associations were similar among the offspring of parents with and without major depression. DDs did not predict adulthood ASPD in either group.
Associations are largely accounted for by conduct disorder (CD), as there were few offspring with ADHD, and oppositional defiant disorder (ODD) was not diagnosed at the time this study began.
If there is no familial risk for ASPD, bipolar disorder or substance use, childhood DDs do not lead to ASPD in adulthood; however, the children still have poorer prognosis into midlife. Early treatment of children with DD, particularly CD, while carefully considering familial risk for these disorders, may help mitigate later adversity.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2018.10.086</identifier><identifier>PMID: 30340098</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Antisocial personality disorder ; Antisocial Personality Disorder - epidemiology ; Attention deficit hyperactivity disorder ; Bipolar Disorder - epidemiology ; Case-Control Studies ; Child ; Child of Impaired Parents - psychology ; Conduct disorder ; Conduct Disorder - epidemiology ; Depressive Disorder, Major - epidemiology ; Disruptive disorders ; Disruptive, Impulse Control, and Conduct Disorders - epidemiology ; Externalizing disorder ; Female ; Humans ; Longitudinal studies ; Male ; Odds Ratio ; Substance-Related Disorders - epidemiology ; Young Adult</subject><ispartof>Journal of affective disorders, 2019-02, Vol.244, p.107-112</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-a119d438a89d19e041b0cd33f63bf51646e3440bed7b77c34af79cd9f11caea33</citedby><cites>FETCH-LOGICAL-c451t-a119d438a89d19e041b0cd33f63bf51646e3440bed7b77c34af79cd9f11caea33</cites><orcidid>0000-0003-4306-9254</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jad.2018.10.086$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30340098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diaz, Alexandre Paim</creatorcontrib><creatorcontrib>Svob, Connie</creatorcontrib><creatorcontrib>Zhao, Ruixin</creatorcontrib><creatorcontrib>DiFabrizio, Baxter</creatorcontrib><creatorcontrib>Warner, Virginia</creatorcontrib><creatorcontrib>Gameroff, Marc J.</creatorcontrib><creatorcontrib>Skipper, Jamie</creatorcontrib><creatorcontrib>Gingrich, Jay</creatorcontrib><creatorcontrib>Posner, Jonathan</creatorcontrib><creatorcontrib>Wickramaratne, Priya J.</creatorcontrib><creatorcontrib>Weissman, Myrna M.</creatorcontrib><creatorcontrib>Talati, Ardesheer</creatorcontrib><title>Adult outcomes of childhood disruptive disorders in offspring of depressed and healthy parents</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>•Childhood disruptive disorders are associated with poor prognosis in adulthood.•Whether parental psychopathology is driving this association is unclear.•We find that even in the absence of familial risk, prognosis is poor.•Children with disruptive disorders grow up to have more depression and substance use.•However in the absence of parental ASPD they do not develop ASPD.
Longitudinal studies of children with disruptive disorders (DDs) have shown high rates of antisocial personality disorder (ASPD) and substance use in adulthood, but few have examined the contribution of parental disorders. We examine child-/adulthood outcomes of DDs in offspring, whose biological parents did not have a history of ASPD, bipolar disorder, or substance use disorders.
Offspring (N = 267) of parents with or without major depression (MDD), but no ASPD or bipolar disorders were followed longitudinally over 33 years, and associations between DDs and psychiatric and functional outcomes were tested.
Eighty-nine (33%) offspring had a DD. Those with, compared to without DDs, had higher rates of MDD (adjusted odds ratio, AOR = 3.42, p < 0.0001), bipolar disorder (AOR = 3.10, p = 0.03), and substance use disorders (AOR = 5.69, p < 0.0001) by age 18, as well as poorer school performance and global functioning. DDs continued to predict MDD and substance use outcomes in adulthood, even after accounting for presence of the corresponding disorder in childhood (MDD: hazards ratio, HR = 3.25, p < 0.0001; SUD, HR = 2.52, p < 0.0001). Associations were similar among the offspring of parents with and without major depression. DDs did not predict adulthood ASPD in either group.
Associations are largely accounted for by conduct disorder (CD), as there were few offspring with ADHD, and oppositional defiant disorder (ODD) was not diagnosed at the time this study began.
If there is no familial risk for ASPD, bipolar disorder or substance use, childhood DDs do not lead to ASPD in adulthood; however, the children still have poorer prognosis into midlife. Early treatment of children with DD, particularly CD, while carefully considering familial risk for these disorders, may help mitigate later adversity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antisocial personality disorder</subject><subject>Antisocial Personality Disorder - epidemiology</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Bipolar Disorder - epidemiology</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child of Impaired Parents - psychology</subject><subject>Conduct disorder</subject><subject>Conduct Disorder - epidemiology</subject><subject>Depressive Disorder, Major - epidemiology</subject><subject>Disruptive disorders</subject><subject>Disruptive, Impulse Control, and Conduct Disorders - epidemiology</subject><subject>Externalizing disorder</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal studies</subject><subject>Male</subject><subject>Odds Ratio</subject><subject>Substance-Related Disorders - epidemiology</subject><subject>Young Adult</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EotvCD-CCcuSSxRM7cSwkpKqCglSJC1yxHM-k8SobBztZqf8eR1squHDy1zPvjPww9gb4Hjg07w_7g8V9xaHN5z1vm2dsB7USZVWDes52malLLip1wS5TOnDOG634S3YhuJCc63bHfl7jOi5FWBcXjpSK0Bdu8CMOIWCBPsV1XvyJtm2ISDEVfspQn-bop_sNR5ojpURY2AmLgey4DA_FbCNNS3rFXvR2TPT6cb1iPz5_-n7zpbz7dvv15vqudLKGpbQAGqVobasRNHEJHXcoRN-Irq-hkQ0JKXlHqDqlnJC2V9qh7gGcJSvEFft4zp3X7kjocu9oR5OHPNr4YIL15t-XyQ_mPpxMI4VsNOSAd48BMfxaKS3m6JOjcbQThTWZCiqhQEtZZxTOqIshpUj9UxvgZvNiDiZ7MZuX7Sp7yTVv_57vqeKPiAx8OAOUf-nkKZrkPE2O0Edyi8Hg_xP_G3CYoNQ</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Diaz, Alexandre Paim</creator><creator>Svob, Connie</creator><creator>Zhao, Ruixin</creator><creator>DiFabrizio, Baxter</creator><creator>Warner, Virginia</creator><creator>Gameroff, Marc J.</creator><creator>Skipper, Jamie</creator><creator>Gingrich, Jay</creator><creator>Posner, Jonathan</creator><creator>Wickramaratne, Priya J.</creator><creator>Weissman, Myrna M.</creator><creator>Talati, Ardesheer</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4306-9254</orcidid></search><sort><creationdate>20190201</creationdate><title>Adult outcomes of childhood disruptive disorders in offspring of depressed and healthy parents</title><author>Diaz, Alexandre Paim ; Svob, Connie ; Zhao, Ruixin ; DiFabrizio, Baxter ; Warner, Virginia ; Gameroff, Marc J. ; Skipper, Jamie ; Gingrich, Jay ; Posner, Jonathan ; Wickramaratne, Priya J. ; Weissman, Myrna M. ; Talati, Ardesheer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-a119d438a89d19e041b0cd33f63bf51646e3440bed7b77c34af79cd9f11caea33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antisocial personality disorder</topic><topic>Antisocial Personality Disorder - epidemiology</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Bipolar Disorder - epidemiology</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child of Impaired Parents - psychology</topic><topic>Conduct disorder</topic><topic>Conduct Disorder - epidemiology</topic><topic>Depressive Disorder, Major - epidemiology</topic><topic>Disruptive disorders</topic><topic>Disruptive, Impulse Control, and Conduct Disorders - epidemiology</topic><topic>Externalizing disorder</topic><topic>Female</topic><topic>Humans</topic><topic>Longitudinal studies</topic><topic>Male</topic><topic>Odds Ratio</topic><topic>Substance-Related Disorders - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diaz, Alexandre Paim</creatorcontrib><creatorcontrib>Svob, Connie</creatorcontrib><creatorcontrib>Zhao, Ruixin</creatorcontrib><creatorcontrib>DiFabrizio, Baxter</creatorcontrib><creatorcontrib>Warner, Virginia</creatorcontrib><creatorcontrib>Gameroff, Marc J.</creatorcontrib><creatorcontrib>Skipper, Jamie</creatorcontrib><creatorcontrib>Gingrich, Jay</creatorcontrib><creatorcontrib>Posner, Jonathan</creatorcontrib><creatorcontrib>Wickramaratne, Priya J.</creatorcontrib><creatorcontrib>Weissman, Myrna M.</creatorcontrib><creatorcontrib>Talati, Ardesheer</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diaz, Alexandre Paim</au><au>Svob, Connie</au><au>Zhao, Ruixin</au><au>DiFabrizio, Baxter</au><au>Warner, Virginia</au><au>Gameroff, Marc J.</au><au>Skipper, Jamie</au><au>Gingrich, Jay</au><au>Posner, Jonathan</au><au>Wickramaratne, Priya J.</au><au>Weissman, Myrna M.</au><au>Talati, Ardesheer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adult outcomes of childhood disruptive disorders in offspring of depressed and healthy parents</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>244</volume><spage>107</spage><epage>112</epage><pages>107-112</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>•Childhood disruptive disorders are associated with poor prognosis in adulthood.•Whether parental psychopathology is driving this association is unclear.•We find that even in the absence of familial risk, prognosis is poor.•Children with disruptive disorders grow up to have more depression and substance use.•However in the absence of parental ASPD they do not develop ASPD.
Longitudinal studies of children with disruptive disorders (DDs) have shown high rates of antisocial personality disorder (ASPD) and substance use in adulthood, but few have examined the contribution of parental disorders. We examine child-/adulthood outcomes of DDs in offspring, whose biological parents did not have a history of ASPD, bipolar disorder, or substance use disorders.
Offspring (N = 267) of parents with or without major depression (MDD), but no ASPD or bipolar disorders were followed longitudinally over 33 years, and associations between DDs and psychiatric and functional outcomes were tested.
Eighty-nine (33%) offspring had a DD. Those with, compared to without DDs, had higher rates of MDD (adjusted odds ratio, AOR = 3.42, p < 0.0001), bipolar disorder (AOR = 3.10, p = 0.03), and substance use disorders (AOR = 5.69, p < 0.0001) by age 18, as well as poorer school performance and global functioning. DDs continued to predict MDD and substance use outcomes in adulthood, even after accounting for presence of the corresponding disorder in childhood (MDD: hazards ratio, HR = 3.25, p < 0.0001; SUD, HR = 2.52, p < 0.0001). Associations were similar among the offspring of parents with and without major depression. DDs did not predict adulthood ASPD in either group.
Associations are largely accounted for by conduct disorder (CD), as there were few offspring with ADHD, and oppositional defiant disorder (ODD) was not diagnosed at the time this study began.
If there is no familial risk for ASPD, bipolar disorder or substance use, childhood DDs do not lead to ASPD in adulthood; however, the children still have poorer prognosis into midlife. Early treatment of children with DD, particularly CD, while carefully considering familial risk for these disorders, may help mitigate later adversity.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30340098</pmid><doi>10.1016/j.jad.2018.10.086</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4306-9254</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of affective disorders, 2019-02, Vol.244, p.107-112 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Antisocial personality disorder Antisocial Personality Disorder - epidemiology Attention deficit hyperactivity disorder Bipolar Disorder - epidemiology Case-Control Studies Child Child of Impaired Parents - psychology Conduct disorder Conduct Disorder - epidemiology Depressive Disorder, Major - epidemiology Disruptive disorders Disruptive, Impulse Control, and Conduct Disorders - epidemiology Externalizing disorder Female Humans Longitudinal studies Male Odds Ratio Substance-Related Disorders - epidemiology Young Adult |
| title | Adult outcomes of childhood disruptive disorders in offspring of depressed and healthy parents |
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