Measurement of lactate levels in postmortem brain, iPSCs, and animal models of schizophrenia

Converging evidence suggests bioenergetic defects contribute to the pathophysiology of schizophrenia and may underlie cognitive dysfunction. The transport and metabolism of lactate energetically couples astrocytes and neurons and supports brain bioenergetics. We examined the concentration of lactate...

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Veröffentlicht in:	Scientific reports 2019-03, Vol.9 (1), p.5087, Article 5087
Hauptverfasser:	Sullivan, Courtney R., Mielnik, Catharine A., Funk, Adam, O’Donovan, Sinead M., Bentea, Eduard, Pletnikov, Mikhail, Ramsey, Amy J., Wen, Zhexing, Rowland, Laura M., McCullumsmith, Robert E.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/2649 631/378/340 Animal models Animals Astrocytes Astrocytes - metabolism Bioenergetics Brain - cytology Brain - metabolism Cognitive ability Diagnosis Disc1 protein Disease Models, Animal Frontal Lobe - cytology Frontal Lobe - metabolism Humanities and Social Sciences Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Inhibitory postsynaptic potentials Lactates - metabolism Lactic acid Male Mental disorders Mice multidisciplinary Mutation Nerve Tissue Proteins - metabolism Neurons - cytology Neurons - metabolism Pluripotency Prefrontal cortex Prefrontal Cortex - cytology Prefrontal Cortex - metabolism Rats Rats, Sprague-Dawley Rodents Schizophrenia Schizophrenia - metabolism Science Science (multidisciplinary) Stem cell transplantation Stem cells
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