Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice

Oligoasthenozoospermia is a major cause of male infertility; however, its etiology and pathogenesis are unclear and may be associated with specific gene abnormalities. This study focused on Tppp2 (tubulin polymerization promoting protein family member 2), whose encoded protein localizes in elongatin...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2019-04, Vol.23 (4), p.2583-2594
Hauptverfasser:	Zhu, Feng, Yan, Peipei, Zhang, Jingjing, Cui, Yiqiang, Zheng, Meimei, Cheng, Yiwei, Guo, Yueshuai, Yang, Xiaoyu, Guo, Xuejiang, Zhu, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrosome Reaction - genetics Adenosine Triphosphate - deficiency Animals Apoptosis ATP Cristae Electron transfer energy metabolism Epididymis Epididymis - metabolism Epididymis - pathology Etiology Female Females Fertility Gene Expression Genes Humans In vitro fertilization Infertility Litter Size Male male subfertility Membrane potential Mice Mice, Knockout Mitochondria Mitochondria - metabolism Mitochondria - pathology Motility Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics oligoasthenozoospermia Oligospermia - genetics Oligospermia - metabolism Oligospermia - pathology Original Pathogenesis Peptide Elongation Factors - genetics Peptide Elongation Factors - metabolism Phenotypes Polymerization Protein Isoforms - genetics Protein Isoforms - metabolism Proteins Proteomics Reproductive technologies Sperm Sperm Capacitation - genetics Sperm Count sperm function Sperm Motility Spermatids Spermatogenesis Spermatozoa - metabolism Spermatozoa - pathology Structure-function relationships Testes Testis - metabolism Testis - pathology TPPP2 Translation Translation elongation Tubulin
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