O‐GlcNAc transferase activates stem‐like cell potential in hepatocarcinoma through O‐GlcNAcylation of eukaryotic initiation factor 4E

O‐GlcNAcylation catalysed by O‐GlcNAc transferase (OGT) is a reversible post‐translational modification. O‐GlcNAcylation participates in transcription, epigenetic regulation, and intracellular signalling. Dysregulation of O‐GlcNAcylation in response to high glucose or OGT expression has been implica...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2019-04, Vol.23 (4), p.2384-2398
Hauptverfasser:	Cao, Benjin, Duan, Meng, Xing, Yang, Liu, Chanjuan, Yang, Fan, Li, Yinan, Yang, Tianxiao, Wei, Yuanyan, Gao, Qiang, Jiang, Jianhai
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Acylation - genetics Aged Antibodies Apoptosis - genetics Biotechnology Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell cycle Cell growth Cell proliferation Cell Proliferation - genetics Diabetes Disease-Free Survival Epigenetics eukaryotic initiation factor 4E Eukaryotic Initiation Factor-4E - genetics Experiments Female Gene expression Gene Expression Regulation, Neoplastic - genetics Gene regulation Glucose Glucose - metabolism Hepatocellular carcinoma Hepatoma Humans Initiation factor eIF-4E Intracellular signalling Liver cancer Liver Neoplasms - genetics Liver Neoplasms - pathology Male Medical prognosis Metabolic disorders Middle Aged N-Acetylglucosaminyltransferases - genetics Neoplastic Stem Cells - pathology O-GlcNAcylation Original O‐GlcNAc transferase Plasmids Prognosis Proteasomes Protein Processing, Post-Translational - genetics Proteins RNA, Small Interfering - genetics Signal transduction Signal Transduction - genetics stem‐like cell potential Survival analysis Threonine Transcription
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