Metformin and tenovin‐6 synergistically induces apoptosis through LKB1‐independent SIRT1 down‐regulation in non‐small cell lung cancer cells

Sirtuin 1 (SIRT1) is known to play a role in a variety of tumorigenesis processes by deacetylating histone and non‐histone proteins; however, antitumour effects by suppressing SIRT1 activity in non‐small cell lung cancer (NSCLC) remain unclear. This study was designed to scrutinize clinicopathologic...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2019-04, Vol.23 (4), p.2872-2889
Hauptverfasser:	Lee, Bo Bin, Kim, Yujin, Kim, Dongho, Cho, Eun Yoon, Han, Joungho, Kim, Hong Kwan, Shim, Young Mog, Kim, Duk‐Hwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adenocarcinoma of Lung - drug therapy Adenocarcinoma of Lung - metabolism Adenocarcinoma of Lung - pathology Antidiabetics Antineoplastic Agents - pharmacology Apoptosis Benzamides - pharmacology Binding sites Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer therapies Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Caspase Cell growth Cell Movement Cell Proliferation Chemotherapy Diabetes Drug Therapy, Combination Female Follow-Up Studies Gene Expression Regulation, Neoplastic - drug effects Growth factors Hepatocytes Histology Histones Humans Hypoglycemic Agents - pharmacology Kinases Liver LKB1 LKB1 protein Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Lysine Male Metformin Metformin - pharmacology Middle Aged Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Non-small cell lung carcinoma non‐small cell lung cancer (NSCLC) Original p53 Protein Paraffin Patients Prognosis Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins SIRT1 inhibitor SIRT1 protein Sirtuin 1 - genetics Sirtuin 1 - metabolism Small cell lung carcinoma Survival Survival Rate tenovin‐6 Transcription factors Tumor Cells, Cultured Tumorigenesis
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