CCL18 promotes the metastasis of squamous cell carcinoma of the head and neck through MTDH‐NF‐κB signalling pathway

Metastasis is one of the primary causes for high mortality in patients with squamous cell carcinoma of the head and neck (SCCHN). Our previous study showed that chemokine (C‐C motif) ligand 18 (CCL18), derived from tumour‐associated macrophages (TAMs), regulates SCCHN metastasis by promoting epithel...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2019-04, Vol.23 (4), p.2689-2701
Hauptverfasser:	Qin, Yuexiang, Wang, Juncheng, Zhu, Gangcai, Li, Guo, Tan, Haolei, Chen, Changhan, Pi, Leiming, She, Li, Chen, Xiyu, Wei, Ming, Li, Zhexuan, Liu, Zhifeng, Huang, Donghai, Liu, Yong, Zhang, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers Breast cancer Cancer therapies Case-Control Studies CCL18 CCL18 protein Cell Line, Tumor Cell Movement Cell Proliferation Chemokines Chemokines, CC - blood Chemokines, CC - genetics Chemotherapy Cloning Dendritic cells Disease Progression EMT Enzyme-linked immunosorbent assay Epithelial-Mesenchymal Transition - genetics Experiments Female Gene expression Gene Expression Regulation, Neoplastic Head & neck cancer Head and Neck Neoplasms - blood Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Humans Leukocyte migration Ligands Liver cancer Lung cancer Lymph nodes Lymphatic Metastasis Lymphatic system Macrophages Male Medical prognosis Membrane Proteins - antagonists & inhibitors Membrane Proteins - blood Membrane Proteins - genetics Mesenchyme Metastases Metastasis Middle Aged MTDH Neck Neoplasm Staging NF-kappa B - blood NF-kappa B - genetics Original Otolaryngology Patients Proteins Radiation therapy RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA-Binding Proteins - antagonists & inhibitors RNA-Binding Proteins - blood RNA-Binding Proteins - genetics SCCHN Serum Signal Transduction Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - blood Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - pathology Surgery Tumors
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