Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations
Objective The aim of this study was to test associations of prepregnancy BMI, gestational weight gain, oral glucose challenge test results, and postpartum weight loss as predictors of breast milk leptin, insulin, and adiponectin concentrations and whether these relationships vary over time. Methods...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2019-04, Vol.27 (4), p.621-628 |
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| creator | Sadr Dadres, Ghazaleh Whitaker, Kara M. Haapala, Jacob L. Foster, Laurie Smith, Katy D. Teague, April M. Jacobs, David R. Kharbanda, Elyse O. McGovern, Patricia M. Schoenfuss, Tonya C. Le, Laura J. Harnack, Lisa Fields, David A. Demerath, Ellen W. |
| description | Objective
The aim of this study was to test associations of prepregnancy BMI, gestational weight gain, oral glucose challenge test results, and postpartum weight loss as predictors of breast milk leptin, insulin, and adiponectin concentrations and whether these relationships vary over time.
Methods
Milk was collected at 1 and 3 months from 135 exclusively breastfeeding women from the longitudinal Mothers and Infants Linked for Healthy Growth (MILk) study. Hormones were assayed in skimmed samples using ELISA. Mixed‐effects linear regression models were employed to assess main effects and effect‐by‐time interactions on hormone concentrations.
Results
In adjusted models, BMI was positively associated with milk leptin (P |
| doi_str_mv | 10.1002/oby.22409 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6432940</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2201678956</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4439-530aaff615a749e8c6163ab74a9aa991bed4fdf0b038a8ed3a8bc5dc45af78d3</originalsourceid><addsrcrecordid>eNp1kV1rFDEUhoMo9kMv_AMS8Eah2yaTzEduhO5WrdBS0YJ6Fc7MnOymziZrkrHsvzd16qKCV0k4D09ezkvIM86OOWPFiW-3x0UhmXpA9rkSbFYL9eXh7t7wPXIQ4w1jsmIlf0z2BFP5wYt9Ej7iAMl6F1d2Q72hl5AwOBjoZ7TLVaKfEqQx0jkaH_CIno3BuuURBdfTU5NR-iHg0oHrtvTWphWdB4SY6KUdvtFzH9beIV1416FLYfroCXlkYIj49P48JNdv31wvzmcXV-_eL04vZp2UQs1KwQCMqXgJtVTYdBWvBLS1BAWgFG-xl6Y3rGWigQZ7AU3blX0nSzB104tD8nrSbsZ2jf0UYNCbYNcQttqD1X9PnF3ppf-hKykKJVkWvLwXBP99xJj02sYOhwEc-jHqgquqLFReZUZf_IPe-PFui5kqGK_qRpVVpl5NVBd8jAHNLgxn-q5InYvUv4rM7PM_0-_I381l4GQCbu2A2_-b9NX866T8CTAgqfU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2201678956</pqid></control><display><type>article</type><title>Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><creator>Sadr Dadres, Ghazaleh ; Whitaker, Kara M. ; Haapala, Jacob L. ; Foster, Laurie ; Smith, Katy D. ; Teague, April M. ; Jacobs, David R. ; Kharbanda, Elyse O. ; McGovern, Patricia M. ; Schoenfuss, Tonya C. ; Le, Laura J. ; Harnack, Lisa ; Fields, David A. ; Demerath, Ellen W.</creator><creatorcontrib>Sadr Dadres, Ghazaleh ; Whitaker, Kara M. ; Haapala, Jacob L. ; Foster, Laurie ; Smith, Katy D. ; Teague, April M. ; Jacobs, David R. ; Kharbanda, Elyse O. ; McGovern, Patricia M. ; Schoenfuss, Tonya C. ; Le, Laura J. ; Harnack, Lisa ; Fields, David A. ; Demerath, Ellen W.</creatorcontrib><description>Objective
The aim of this study was to test associations of prepregnancy BMI, gestational weight gain, oral glucose challenge test results, and postpartum weight loss as predictors of breast milk leptin, insulin, and adiponectin concentrations and whether these relationships vary over time.
Methods
Milk was collected at 1 and 3 months from 135 exclusively breastfeeding women from the longitudinal Mothers and Infants Linked for Healthy Growth (MILk) study. Hormones were assayed in skimmed samples using ELISA. Mixed‐effects linear regression models were employed to assess main effects and effect‐by‐time interactions on hormone concentrations.
Results
In adjusted models, BMI was positively associated with milk leptin (P < 0.001) and insulin (P = 0.03) and negatively associated with milk adiponectin (P = 0.02); however, the association was stronger with insulin and weaker with adiponectin at 3 months than at 1 month (time interaction P = 0.017 for insulin and P = 0.045 for adiponectin). Gestational weight gain was positively associated and postpartum weight loss was negatively associated with milk leptin (both P < 0.001), independent of BMI. Oral glucose challenge test results were not associated with these milk hormone concentrations.
Conclusions
Maternal weight status before, during, and after pregnancy contributes to interindividual variation in human milk composition. Continuing work will assess the role of these and other milk bioactive factors in altering infant metabolic outcomes.</description><identifier>ISSN: 1930-7381</identifier><identifier>ISSN: 1930-739X</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.22409</identifier><identifier>PMID: 30900412</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adiponectin - analysis ; Adiponectin - metabolism ; Adult ; Babies ; Body Weight - physiology ; Breast Feeding ; Breastfeeding & lactation ; Congenital diseases ; Diabetes ; Female ; Glucose Tolerance Test ; Health sciences ; Hormones ; Humans ; Hypotheses ; Infant, Newborn ; Insulin ; Insulin - analysis ; Insulin - metabolism ; Leptin - analysis ; Leptin - metabolism ; Longitudinal Studies ; Metabolism ; Middle Aged ; Milk, Human - chemistry ; Milk, Human - metabolism ; Mothers ; Obesity ; Postpartum Period - metabolism ; Pregnancy ; Studies ; Weight control ; Womens health ; Young Adult</subject><ispartof>Obesity (Silver Spring, Md.), 2019-04, Vol.27 (4), p.621-628</ispartof><rights>2019 The Obesity Society</rights><rights>2019 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Apr 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4439-530aaff615a749e8c6163ab74a9aa991bed4fdf0b038a8ed3a8bc5dc45af78d3</citedby><cites>FETCH-LOGICAL-c4439-530aaff615a749e8c6163ab74a9aa991bed4fdf0b038a8ed3a8bc5dc45af78d3</cites><orcidid>0000-0003-2343-4162 ; 0000-0002-4585-4064</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.22409$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.22409$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30900412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sadr Dadres, Ghazaleh</creatorcontrib><creatorcontrib>Whitaker, Kara M.</creatorcontrib><creatorcontrib>Haapala, Jacob L.</creatorcontrib><creatorcontrib>Foster, Laurie</creatorcontrib><creatorcontrib>Smith, Katy D.</creatorcontrib><creatorcontrib>Teague, April M.</creatorcontrib><creatorcontrib>Jacobs, David R.</creatorcontrib><creatorcontrib>Kharbanda, Elyse O.</creatorcontrib><creatorcontrib>McGovern, Patricia M.</creatorcontrib><creatorcontrib>Schoenfuss, Tonya C.</creatorcontrib><creatorcontrib>Le, Laura J.</creatorcontrib><creatorcontrib>Harnack, Lisa</creatorcontrib><creatorcontrib>Fields, David A.</creatorcontrib><creatorcontrib>Demerath, Ellen W.</creatorcontrib><title>Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
The aim of this study was to test associations of prepregnancy BMI, gestational weight gain, oral glucose challenge test results, and postpartum weight loss as predictors of breast milk leptin, insulin, and adiponectin concentrations and whether these relationships vary over time.
Methods
Milk was collected at 1 and 3 months from 135 exclusively breastfeeding women from the longitudinal Mothers and Infants Linked for Healthy Growth (MILk) study. Hormones were assayed in skimmed samples using ELISA. Mixed‐effects linear regression models were employed to assess main effects and effect‐by‐time interactions on hormone concentrations.
Results
In adjusted models, BMI was positively associated with milk leptin (P < 0.001) and insulin (P = 0.03) and negatively associated with milk adiponectin (P = 0.02); however, the association was stronger with insulin and weaker with adiponectin at 3 months than at 1 month (time interaction P = 0.017 for insulin and P = 0.045 for adiponectin). Gestational weight gain was positively associated and postpartum weight loss was negatively associated with milk leptin (both P < 0.001), independent of BMI. Oral glucose challenge test results were not associated with these milk hormone concentrations.
Conclusions
Maternal weight status before, during, and after pregnancy contributes to interindividual variation in human milk composition. Continuing work will assess the role of these and other milk bioactive factors in altering infant metabolic outcomes.</description><subject>Adiponectin - analysis</subject><subject>Adiponectin - metabolism</subject><subject>Adult</subject><subject>Babies</subject><subject>Body Weight - physiology</subject><subject>Breast Feeding</subject><subject>Breastfeeding & lactation</subject><subject>Congenital diseases</subject><subject>Diabetes</subject><subject>Female</subject><subject>Glucose Tolerance Test</subject><subject>Health sciences</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Infant, Newborn</subject><subject>Insulin</subject><subject>Insulin - analysis</subject><subject>Insulin - metabolism</subject><subject>Leptin - analysis</subject><subject>Leptin - metabolism</subject><subject>Longitudinal Studies</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Milk, Human - chemistry</subject><subject>Milk, Human - metabolism</subject><subject>Mothers</subject><subject>Obesity</subject><subject>Postpartum Period - metabolism</subject><subject>Pregnancy</subject><subject>Studies</subject><subject>Weight control</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>1930-7381</issn><issn>1930-739X</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV1rFDEUhoMo9kMv_AMS8Eah2yaTzEduhO5WrdBS0YJ6Fc7MnOymziZrkrHsvzd16qKCV0k4D09ezkvIM86OOWPFiW-3x0UhmXpA9rkSbFYL9eXh7t7wPXIQ4w1jsmIlf0z2BFP5wYt9Ej7iAMl6F1d2Q72hl5AwOBjoZ7TLVaKfEqQx0jkaH_CIno3BuuURBdfTU5NR-iHg0oHrtvTWphWdB4SY6KUdvtFzH9beIV1416FLYfroCXlkYIj49P48JNdv31wvzmcXV-_eL04vZp2UQs1KwQCMqXgJtVTYdBWvBLS1BAWgFG-xl6Y3rGWigQZ7AU3blX0nSzB104tD8nrSbsZ2jf0UYNCbYNcQttqD1X9PnF3ppf-hKykKJVkWvLwXBP99xJj02sYOhwEc-jHqgquqLFReZUZf_IPe-PFui5kqGK_qRpVVpl5NVBd8jAHNLgxn-q5InYvUv4rM7PM_0-_I381l4GQCbu2A2_-b9NX866T8CTAgqfU</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Sadr Dadres, Ghazaleh</creator><creator>Whitaker, Kara M.</creator><creator>Haapala, Jacob L.</creator><creator>Foster, Laurie</creator><creator>Smith, Katy D.</creator><creator>Teague, April M.</creator><creator>Jacobs, David R.</creator><creator>Kharbanda, Elyse O.</creator><creator>McGovern, Patricia M.</creator><creator>Schoenfuss, Tonya C.</creator><creator>Le, Laura J.</creator><creator>Harnack, Lisa</creator><creator>Fields, David A.</creator><creator>Demerath, Ellen W.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2343-4162</orcidid><orcidid>https://orcid.org/0000-0002-4585-4064</orcidid></search><sort><creationdate>201904</creationdate><title>Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations</title><author>Sadr Dadres, Ghazaleh ; Whitaker, Kara M. ; Haapala, Jacob L. ; Foster, Laurie ; Smith, Katy D. ; Teague, April M. ; Jacobs, David R. ; Kharbanda, Elyse O. ; McGovern, Patricia M. ; Schoenfuss, Tonya C. ; Le, Laura J. ; Harnack, Lisa ; Fields, David A. ; Demerath, Ellen W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4439-530aaff615a749e8c6163ab74a9aa991bed4fdf0b038a8ed3a8bc5dc45af78d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adiponectin - analysis</topic><topic>Adiponectin - metabolism</topic><topic>Adult</topic><topic>Babies</topic><topic>Body Weight - physiology</topic><topic>Breast Feeding</topic><topic>Breastfeeding & lactation</topic><topic>Congenital diseases</topic><topic>Diabetes</topic><topic>Female</topic><topic>Glucose Tolerance Test</topic><topic>Health sciences</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Infant, Newborn</topic><topic>Insulin</topic><topic>Insulin - analysis</topic><topic>Insulin - metabolism</topic><topic>Leptin - analysis</topic><topic>Leptin - metabolism</topic><topic>Longitudinal Studies</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Milk, Human - chemistry</topic><topic>Milk, Human - metabolism</topic><topic>Mothers</topic><topic>Obesity</topic><topic>Postpartum Period - metabolism</topic><topic>Pregnancy</topic><topic>Studies</topic><topic>Weight control</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sadr Dadres, Ghazaleh</creatorcontrib><creatorcontrib>Whitaker, Kara M.</creatorcontrib><creatorcontrib>Haapala, Jacob L.</creatorcontrib><creatorcontrib>Foster, Laurie</creatorcontrib><creatorcontrib>Smith, Katy D.</creatorcontrib><creatorcontrib>Teague, April M.</creatorcontrib><creatorcontrib>Jacobs, David R.</creatorcontrib><creatorcontrib>Kharbanda, Elyse O.</creatorcontrib><creatorcontrib>McGovern, Patricia M.</creatorcontrib><creatorcontrib>Schoenfuss, Tonya C.</creatorcontrib><creatorcontrib>Le, Laura J.</creatorcontrib><creatorcontrib>Harnack, Lisa</creatorcontrib><creatorcontrib>Fields, David A.</creatorcontrib><creatorcontrib>Demerath, Ellen W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sadr Dadres, Ghazaleh</au><au>Whitaker, Kara M.</au><au>Haapala, Jacob L.</au><au>Foster, Laurie</au><au>Smith, Katy D.</au><au>Teague, April M.</au><au>Jacobs, David R.</au><au>Kharbanda, Elyse O.</au><au>McGovern, Patricia M.</au><au>Schoenfuss, Tonya C.</au><au>Le, Laura J.</au><au>Harnack, Lisa</au><au>Fields, David A.</au><au>Demerath, Ellen W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2019-04</date><risdate>2019</risdate><volume>27</volume><issue>4</issue><spage>621</spage><epage>628</epage><pages>621-628</pages><issn>1930-7381</issn><issn>1930-739X</issn><eissn>1930-739X</eissn><abstract>Objective
The aim of this study was to test associations of prepregnancy BMI, gestational weight gain, oral glucose challenge test results, and postpartum weight loss as predictors of breast milk leptin, insulin, and adiponectin concentrations and whether these relationships vary over time.
Methods
Milk was collected at 1 and 3 months from 135 exclusively breastfeeding women from the longitudinal Mothers and Infants Linked for Healthy Growth (MILk) study. Hormones were assayed in skimmed samples using ELISA. Mixed‐effects linear regression models were employed to assess main effects and effect‐by‐time interactions on hormone concentrations.
Results
In adjusted models, BMI was positively associated with milk leptin (P < 0.001) and insulin (P = 0.03) and negatively associated with milk adiponectin (P = 0.02); however, the association was stronger with insulin and weaker with adiponectin at 3 months than at 1 month (time interaction P = 0.017 for insulin and P = 0.045 for adiponectin). Gestational weight gain was positively associated and postpartum weight loss was negatively associated with milk leptin (both P < 0.001), independent of BMI. Oral glucose challenge test results were not associated with these milk hormone concentrations.
Conclusions
Maternal weight status before, during, and after pregnancy contributes to interindividual variation in human milk composition. Continuing work will assess the role of these and other milk bioactive factors in altering infant metabolic outcomes.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>30900412</pmid><doi>10.1002/oby.22409</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2343-4162</orcidid><orcidid>https://orcid.org/0000-0002-4585-4064</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1930-7381 |
| ispartof | Obesity (Silver Spring, Md.), 2019-04, Vol.27 (4), p.621-628 |
| issn | 1930-7381 1930-739X 1930-739X |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library; Wiley Online Library (Open Access Collection) |
| subjects | Adiponectin - analysis Adiponectin - metabolism Adult Babies Body Weight - physiology Breast Feeding Breastfeeding & lactation Congenital diseases Diabetes Female Glucose Tolerance Test Health sciences Hormones Humans Hypotheses Infant, Newborn Insulin Insulin - analysis Insulin - metabolism Leptin - analysis Leptin - metabolism Longitudinal Studies Metabolism Middle Aged Milk, Human - chemistry Milk, Human - metabolism Mothers Obesity Postpartum Period - metabolism Pregnancy Studies Weight control Womens health Young Adult |
| title | Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations |
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