AHR Regulates Metabolic Reprogramming to Promote SIRT1-Dependent Keratinocyte Differentiation

Activation of the transcription factor, AHR, in normal human epidermal keratinocytes increased AHR binding in the gene regions of the glucose transporter, SLC2A1, and the glycolytic enzyme, ENO1. This increased chromatin binding corresponded with AHR-dependent decreases in levels of SLC2A1 and ENO1...

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Veröffentlicht in:	Journal of investigative dermatology 2019-04, Vol.139 (4), p.818-826
Hauptverfasser:	Sutter, Carrie Hayes, Olesen, Kristin M., Bhuju, Jyoti, Guo, Zibiao, Sutter, Thomas R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Cells, Cultured DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Epidermis - metabolism Gene Expression Regulation Glucose - metabolism Glucose Transporter Type 1 - biosynthesis Glucose Transporter Type 1 - genetics Glycolysis - physiology Humans Keratinocytes - cytology Keratinocytes - metabolism Phosphopyruvate Hydratase - biosynthesis Phosphopyruvate Hydratase - genetics Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism RNA - genetics Sirtuin 1 - biosynthesis Sirtuin 1 - genetics Tumor Suppressor Proteins - biosynthesis Tumor Suppressor Proteins - genetics
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