Safety and cardiovascular efficacy of spironolactone in dialysis-dependent ESRD (SPin-D): a randomized, placebo-controlled, multiple dosage trial

The safety and efficacy of spironolactone is uncertain in end-stage renal disease. We randomized 129 maintenance hemodialysis patients to placebo (n=51) or spironolactone 12.5 mg (n=27), 25 mg (n=26), or 50 mg (n=25) daily for 36 weeks in a double-blind, placebo-controlled, multiple dosage trial to...

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Veröffentlicht in:	Kidney international 2019-04, Vol.95 (4), p.973-982
Hauptverfasser:	Charytan, David M., Himmelfarb, Jonathan, Ikizler, T. Alp, Raj, Dominic S., Hsu, Jesse Y., Landis, J. Richard, Anderson, Amanda H., Hung, Adriana M., Mehrotra, Rajnish, Sharma, Shailendra, Weiner, Daniel E., Williams, Mark, DiCarli, Marcelo, Skali, Hicham, Kimmel, Paul L., Kliger, Alan S., Dember, Laura M., Kliger, Alan, Robinson, Emily, Aurien-Blajeni, Ezra, Cinelli, Maria Angeles, Nizam, Tayyaba, Rim, Sookyung, Seok, Paul, Smith, Caroline, Rollins, Jasmine, Raj, Dominic, Regunathan-Shenk, Renu, Ramezani, Ali, Andrews, Sarah, Dumadag, Michelle, Franco, Christina, Wing, Maria, Anderson, Lisa, Linke, Lori, Manahan, Linda, Hung, Adriana, Cavanaugh, Kerri, Booker, Cindy, Brannon, Brigitte, Clagett, Adrienne, Ellis, Charles, Dember, Laura, Anderson, Amanda, Hsu, Jesse, Cifelli, Denise, Ballard, Shawn, Durborow, Marie, Howard, Tamara, Kuzla, Natalie, Nessel, Lisa, Tierney, Ann, Solomon, Scott, Rad, Aria, Di Carli, Marcelo, Gaber, Masha, Foster, Courtney, Kimmel, Paul, Kusek, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aldosterone - metabolism Cardiovascular Diseases - diagnostic imaging Cardiovascular Diseases - prevention & control Diastole - drug effects Dose-Response Relationship, Drug Double-Blind Method Echocardiography, Doppler Feasibility Studies Female Gynecomastia - chemically induced Gynecomastia - epidemiology hemodialysis Humans Hyperkalemia - blood Hyperkalemia - chemically induced Hyperkalemia - epidemiology Hypotension - chemically induced Hypotension - epidemiology Kidney Failure, Chronic - complications Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - therapy Male Middle Aged mineralocorticoid blockade Mineralocorticoid Receptor Antagonists - administration & dosage Mineralocorticoid Receptor Antagonists - adverse effects multiple dosage Placebos - administration & dosage Placebos - adverse effects Potassium - blood randomized controlled trial Renal Dialysis Spironolactone - administration & dosage Spironolactone - adverse effects
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