Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators
The cyclin and cystathionine β-synthase (CBS) domain magnesium transport mediators, CNNMs, are key players in maintaining the homeostasis of magnesium in different organs. The human family includes four members, whose impaired activity causes diseases such as Jalili Syndrome or Familial Hypomagnesem...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2019-03, Vol.20 (5), p.1135 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | 1135 |
| container_title | International journal of molecular sciences |
| container_volume | 20 |
| creator | Giménez-Mascarell, Paula González-Recio, Irene Fernández-Rodríguez, Cármen Oyenarte, Iker Müller, Dominik Martínez-Chantar, María Luz Martínez-Cruz, Luis Alfonso |
| description | The cyclin and cystathionine β-synthase (CBS) domain magnesium transport mediators, CNNMs, are key players in maintaining the homeostasis of magnesium in different organs. The human family includes four members, whose impaired activity causes diseases such as Jalili Syndrome or Familial Hypomagnesemia, but is also linked to neuropathologic disorders, altered blood pressure, and infertility. Recent findings demonstrated that CNNMs are associated with the highly oncogenic phosphatases of the regenerating liver to promote tumor growth and metastasis, which has attracted renewed focus on their potential exploitation as targets for cancer treatment. However, the exact function of CNNMs remains unclear and is subject to debate, proposed as either direct transporters, sensors, or homeostatic factors. This review gathers the current structural knowledge on the CNNM family, highlighting similarities and differences with the closely related structural partners such as the bacterial Mg
/Co
efflux protein CorC and the Mg
channel MgtE. |
| doi_str_mv | 10.3390/ijms20051135 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6429129</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2189561891</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-ac7aebfebb5b2f7351a29e043741b98028c46aaeec558086b291c9a225cb5ac63</originalsourceid><addsrcrecordid>eNpdkc1LAzEQxYMotlZvniXgxYPVfGx2NxdBilXRVsF6Dtl0tt2yu6nJrtL_3khrqV5mBubH4z0eQqeUXHEuyXWxqDwjRFDKxR7q0oixPiFxsr9zd9CR9wtCGGdCHqIOJ2kk4kh20eugdQ7qBr81rjVN63SJn2r7VcJ0BtjWuJkDHozHIzzUVVGusM3xSM9q8EVb4YnTtV9a1-ARTAvdWOeP0UGuSw8nm91D78O7yeCh__xy_zi4fe6bKEmbvjaJhiyHLBMZyxMuqGYSSMSTiGYyJSw1Uaw1gBEiJWmcMUmN1IwJkwltYt5DN2vdZZtVMDUhQ_Culq6otFspqwv191MXczWznyqOghSTQeBiI-DsRwu-UVXhDZSlrsG2XjGaShGHQQN6_g9d2NbVIZ5inDPGKRFpoC7XlHHWewf51gwl6qcqtVtVwM92A2zh3274N3NDkBk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2332231058</pqid></control><display><type>article</type><title>Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Giménez-Mascarell, Paula ; González-Recio, Irene ; Fernández-Rodríguez, Cármen ; Oyenarte, Iker ; Müller, Dominik ; Martínez-Chantar, María Luz ; Martínez-Cruz, Luis Alfonso</creator><creatorcontrib>Giménez-Mascarell, Paula ; González-Recio, Irene ; Fernández-Rodríguez, Cármen ; Oyenarte, Iker ; Müller, Dominik ; Martínez-Chantar, María Luz ; Martínez-Cruz, Luis Alfonso</creatorcontrib><description>The cyclin and cystathionine β-synthase (CBS) domain magnesium transport mediators, CNNMs, are key players in maintaining the homeostasis of magnesium in different organs. The human family includes four members, whose impaired activity causes diseases such as Jalili Syndrome or Familial Hypomagnesemia, but is also linked to neuropathologic disorders, altered blood pressure, and infertility. Recent findings demonstrated that CNNMs are associated with the highly oncogenic phosphatases of the regenerating liver to promote tumor growth and metastasis, which has attracted renewed focus on their potential exploitation as targets for cancer treatment. However, the exact function of CNNMs remains unclear and is subject to debate, proposed as either direct transporters, sensors, or homeostatic factors. This review gathers the current structural knowledge on the CNNM family, highlighting similarities and differences with the closely related structural partners such as the bacterial Mg
/Co
efflux protein CorC and the Mg
channel MgtE.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms20051135</identifier><identifier>PMID: 30845649</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Amino acid sequence ; Amino acids ; Biomedical materials ; Blood pressure ; Cation Transport Proteins - chemistry ; Cation Transport Proteins - genetics ; Cation Transport Proteins - metabolism ; Cell division ; Cell membranes ; Colon ; Crystallography, X-Ray ; Diabetes ; Diabetes mellitus ; Genomes ; Glucose metabolism ; Humans ; Hypertension ; Hypomagnesemia ; Immunodeficiency ; Insulin ; Intestine ; Magnesium ; Magnesium - metabolism ; Membranes ; Models, Molecular ; Muscles ; Mutation ; Neoplasms - genetics ; Neoplasms - metabolism ; Nucleotide sequence ; Osteoporosis ; Peptides ; Phosphoric Monoester Hydrolases - metabolism ; Protein Binding ; Proteins ; Rare diseases ; Review ; Skeletal muscle ; Small intestine ; Sperm ; Spleen</subject><ispartof>International journal of molecular sciences, 2019-03, Vol.20 (5), p.1135</ispartof><rights>2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-ac7aebfebb5b2f7351a29e043741b98028c46aaeec558086b291c9a225cb5ac63</citedby><cites>FETCH-LOGICAL-c478t-ac7aebfebb5b2f7351a29e043741b98028c46aaeec558086b291c9a225cb5ac63</cites><orcidid>0000-0002-5856-9377 ; 0000-0002-3478-1576</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429129/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429129/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30845649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giménez-Mascarell, Paula</creatorcontrib><creatorcontrib>González-Recio, Irene</creatorcontrib><creatorcontrib>Fernández-Rodríguez, Cármen</creatorcontrib><creatorcontrib>Oyenarte, Iker</creatorcontrib><creatorcontrib>Müller, Dominik</creatorcontrib><creatorcontrib>Martínez-Chantar, María Luz</creatorcontrib><creatorcontrib>Martínez-Cruz, Luis Alfonso</creatorcontrib><title>Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The cyclin and cystathionine β-synthase (CBS) domain magnesium transport mediators, CNNMs, are key players in maintaining the homeostasis of magnesium in different organs. The human family includes four members, whose impaired activity causes diseases such as Jalili Syndrome or Familial Hypomagnesemia, but is also linked to neuropathologic disorders, altered blood pressure, and infertility. Recent findings demonstrated that CNNMs are associated with the highly oncogenic phosphatases of the regenerating liver to promote tumor growth and metastasis, which has attracted renewed focus on their potential exploitation as targets for cancer treatment. However, the exact function of CNNMs remains unclear and is subject to debate, proposed as either direct transporters, sensors, or homeostatic factors. This review gathers the current structural knowledge on the CNNM family, highlighting similarities and differences with the closely related structural partners such as the bacterial Mg
/Co
efflux protein CorC and the Mg
channel MgtE.</description><subject>Amino acid sequence</subject><subject>Amino acids</subject><subject>Biomedical materials</subject><subject>Blood pressure</subject><subject>Cation Transport Proteins - chemistry</subject><subject>Cation Transport Proteins - genetics</subject><subject>Cation Transport Proteins - metabolism</subject><subject>Cell division</subject><subject>Cell membranes</subject><subject>Colon</subject><subject>Crystallography, X-Ray</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Genomes</subject><subject>Glucose metabolism</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypomagnesemia</subject><subject>Immunodeficiency</subject><subject>Insulin</subject><subject>Intestine</subject><subject>Magnesium</subject><subject>Magnesium - metabolism</subject><subject>Membranes</subject><subject>Models, Molecular</subject><subject>Muscles</subject><subject>Mutation</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Nucleotide sequence</subject><subject>Osteoporosis</subject><subject>Peptides</subject><subject>Phosphoric Monoester Hydrolases - metabolism</subject><subject>Protein Binding</subject><subject>Proteins</subject><subject>Rare diseases</subject><subject>Review</subject><subject>Skeletal muscle</subject><subject>Small intestine</subject><subject>Sperm</subject><subject>Spleen</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkc1LAzEQxYMotlZvniXgxYPVfGx2NxdBilXRVsF6Dtl0tt2yu6nJrtL_3khrqV5mBubH4z0eQqeUXHEuyXWxqDwjRFDKxR7q0oixPiFxsr9zd9CR9wtCGGdCHqIOJ2kk4kh20eugdQ7qBr81rjVN63SJn2r7VcJ0BtjWuJkDHozHIzzUVVGusM3xSM9q8EVb4YnTtV9a1-ARTAvdWOeP0UGuSw8nm91D78O7yeCh__xy_zi4fe6bKEmbvjaJhiyHLBMZyxMuqGYSSMSTiGYyJSw1Uaw1gBEiJWmcMUmN1IwJkwltYt5DN2vdZZtVMDUhQ_Culq6otFspqwv191MXczWznyqOghSTQeBiI-DsRwu-UVXhDZSlrsG2XjGaShGHQQN6_g9d2NbVIZ5inDPGKRFpoC7XlHHWewf51gwl6qcqtVtVwM92A2zh3274N3NDkBk</recordid><startdate>20190306</startdate><enddate>20190306</enddate><creator>Giménez-Mascarell, Paula</creator><creator>González-Recio, Irene</creator><creator>Fernández-Rodríguez, Cármen</creator><creator>Oyenarte, Iker</creator><creator>Müller, Dominik</creator><creator>Martínez-Chantar, María Luz</creator><creator>Martínez-Cruz, Luis Alfonso</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5856-9377</orcidid><orcidid>https://orcid.org/0000-0002-3478-1576</orcidid></search><sort><creationdate>20190306</creationdate><title>Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators</title><author>Giménez-Mascarell, Paula ; González-Recio, Irene ; Fernández-Rodríguez, Cármen ; Oyenarte, Iker ; Müller, Dominik ; Martínez-Chantar, María Luz ; Martínez-Cruz, Luis Alfonso</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-ac7aebfebb5b2f7351a29e043741b98028c46aaeec558086b291c9a225cb5ac63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Amino acid sequence</topic><topic>Amino acids</topic><topic>Biomedical materials</topic><topic>Blood pressure</topic><topic>Cation Transport Proteins - chemistry</topic><topic>Cation Transport Proteins - genetics</topic><topic>Cation Transport Proteins - metabolism</topic><topic>Cell division</topic><topic>Cell membranes</topic><topic>Colon</topic><topic>Crystallography, X-Ray</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Genomes</topic><topic>Glucose metabolism</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypomagnesemia</topic><topic>Immunodeficiency</topic><topic>Insulin</topic><topic>Intestine</topic><topic>Magnesium</topic><topic>Magnesium - metabolism</topic><topic>Membranes</topic><topic>Models, Molecular</topic><topic>Muscles</topic><topic>Mutation</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Nucleotide sequence</topic><topic>Osteoporosis</topic><topic>Peptides</topic><topic>Phosphoric Monoester Hydrolases - metabolism</topic><topic>Protein Binding</topic><topic>Proteins</topic><topic>Rare diseases</topic><topic>Review</topic><topic>Skeletal muscle</topic><topic>Small intestine</topic><topic>Sperm</topic><topic>Spleen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giménez-Mascarell, Paula</creatorcontrib><creatorcontrib>González-Recio, Irene</creatorcontrib><creatorcontrib>Fernández-Rodríguez, Cármen</creatorcontrib><creatorcontrib>Oyenarte, Iker</creatorcontrib><creatorcontrib>Müller, Dominik</creatorcontrib><creatorcontrib>Martínez-Chantar, María Luz</creatorcontrib><creatorcontrib>Martínez-Cruz, Luis Alfonso</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giménez-Mascarell, Paula</au><au>González-Recio, Irene</au><au>Fernández-Rodríguez, Cármen</au><au>Oyenarte, Iker</au><au>Müller, Dominik</au><au>Martínez-Chantar, María Luz</au><au>Martínez-Cruz, Luis Alfonso</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2019-03-06</date><risdate>2019</risdate><volume>20</volume><issue>5</issue><spage>1135</spage><pages>1135-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>The cyclin and cystathionine β-synthase (CBS) domain magnesium transport mediators, CNNMs, are key players in maintaining the homeostasis of magnesium in different organs. The human family includes four members, whose impaired activity causes diseases such as Jalili Syndrome or Familial Hypomagnesemia, but is also linked to neuropathologic disorders, altered blood pressure, and infertility. Recent findings demonstrated that CNNMs are associated with the highly oncogenic phosphatases of the regenerating liver to promote tumor growth and metastasis, which has attracted renewed focus on their potential exploitation as targets for cancer treatment. However, the exact function of CNNMs remains unclear and is subject to debate, proposed as either direct transporters, sensors, or homeostatic factors. This review gathers the current structural knowledge on the CNNM family, highlighting similarities and differences with the closely related structural partners such as the bacterial Mg
/Co
efflux protein CorC and the Mg
channel MgtE.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30845649</pmid><doi>10.3390/ijms20051135</doi><orcidid>https://orcid.org/0000-0002-5856-9377</orcidid><orcidid>https://orcid.org/0000-0002-3478-1576</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2019-03, Vol.20 (5), p.1135 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6429129 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Amino acid sequence Amino acids Biomedical materials Blood pressure Cation Transport Proteins - chemistry Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Cell division Cell membranes Colon Crystallography, X-Ray Diabetes Diabetes mellitus Genomes Glucose metabolism Humans Hypertension Hypomagnesemia Immunodeficiency Insulin Intestine Magnesium Magnesium - metabolism Membranes Models, Molecular Muscles Mutation Neoplasms - genetics Neoplasms - metabolism Nucleotide sequence Osteoporosis Peptides Phosphoric Monoester Hydrolases - metabolism Protein Binding Proteins Rare diseases Review Skeletal muscle Small intestine Sperm Spleen |
| title | Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T02%3A40%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Current%20Structural%20Knowledge%20on%20the%20CNNM%20Family%20of%20Magnesium%20Transport%20Mediators&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Gim%C3%A9nez-Mascarell,%20Paula&rft.date=2019-03-06&rft.volume=20&rft.issue=5&rft.spage=1135&rft.pages=1135-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms20051135&rft_dat=%3Cproquest_pubme%3E2189561891%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2332231058&rft_id=info:pmid/30845649&rfr_iscdi=true |