Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations
Papillary thyroid cancer (PTC) is the most prevalent form of malignancy among all cancers of the thyroid. It is also one of the few cancers with a rapidly increasing incidence. PTC is usually contained within the thyroid gland and generally biologically indolent. Prognosis of the cancer is excellent...
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| Veröffentlicht in: | International journal of medical sciences 2019-01, Vol.16 (3), p.450-460 |
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| container_title | International journal of medical sciences |
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| creator | Abdullah, Mardiaty Iryani Junit, Sarni Mat Ng, Khoon Leong Jayapalan, Jaime Jacqueline Karikalan, Barani Hashim, Onn Haji |
| description | Papillary thyroid cancer (PTC) is the most prevalent form of malignancy among all cancers of the thyroid. It is also one of the few cancers with a rapidly increasing incidence. PTC is usually contained within the thyroid gland and generally biologically indolent. Prognosis of the cancer is excellent, with less than 2% mortality at 5 years. However, more than 25% of patients with PTC developed a recurrence during a long term follow-up. The present article provides an updated condensed overview of PTC, which focuses mainly on the molecular alterations involved and recent biomarker investigations. |
| doi_str_mv | 10.7150/ijms.29935 |
| format | Article |
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| subjects | Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Female Goiter, Nodular - complications Humans Male MicroRNAs Neoplasm Recurrence, Local - genetics Proteomics Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins c-ret - genetics ras Proteins - genetics Review Thyroid Cancer, Papillary - diagnosis Thyroid Cancer, Papillary - genetics Thyroid Cancer, Papillary - therapy Thyroid Neoplasms - diagnosis Thyroid Neoplasms - genetics Thyroid Neoplasms - therapy |
| title | Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations |
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