Coarse-Grained Simulation of Full-Length Integrin Activation

Integrin conformational dynamics are critical to their receptor and signaling functions in many cellular processes, including spreading, adhesion, and migration. However, assessing integrin conformations is both experimentally and computationally challenging because of limitations in resolution and...

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Veröffentlicht in:	Biophysical journal 2019-03, Vol.116 (6), p.1000-1010
Hauptverfasser:	Bidone, Tamara C., Polley, Anirban, Jin, Jaehyeok, Driscoll, Tristan, Iwamoto, Daniel V., Calderwood, David A., Schwartz, Martin A., Voth, Gregory A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Integrins - chemistry Integrins - genetics Integrins - metabolism Molecular Dynamics Simulation Mutation Protein Conformation
Online-Zugang:	Volltext
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