Association between Periodontal Disease and Subsequent Sjögren's Syndrome: A Nationwide Population-Based Cohort Study
Xerostomia (dry mouth) is the cardinal symptom of Sjögren's syndrome (SS), which is an autoimmune disease involving the exocrine glands and other organs. Xerostomia may predispose patients to periodontal disease (PD) and an association between SS and PD has been reported. This association may b...
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| Veröffentlicht in: | International journal of environmental research and public health 2019-03, Vol.16 (5), p.771 |
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| description | Xerostomia (dry mouth) is the cardinal symptom of Sjögren's syndrome (SS), which is an autoimmune disease involving the exocrine glands and other organs. Xerostomia may predispose patients to periodontal disease (PD) and an association between SS and PD has been reported. This association may be bidirectional; therefore, we conducted this study to investigate the risk of SS in patients with PD using data from the National Health Insurance Research Database of Taiwan. A total of 135,190 patients were enrolled in our analysis. In all, 27,041 patients with PD were matched by gender, age, insured region, urbanization and income, with cases and controls in a 1:4 ratio. Both groups were followed and the risks of SS were calculated by Cox proportional hazards regression. Finally, 3292 (2.4%) patients had newly diagnosed SS. Patients with PD had a significantly higher risk of subsequent SS (903 (3.3%) vs. 2389 (2.2%), adjusted hazard 1.47, 95% confidence interval: 1.36⁻1.59). In conclusion, patients with PD had an approximately 50% increased risk of subsequent SS. Physicians should be aware of the symptoms and signs of SS in patients with PD. |
| doi_str_mv | 10.3390/ijerph16050771 |
| format | Article |
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Xerostomia may predispose patients to periodontal disease (PD) and an association between SS and PD has been reported. This association may be bidirectional; therefore, we conducted this study to investigate the risk of SS in patients with PD using data from the National Health Insurance Research Database of Taiwan. A total of 135,190 patients were enrolled in our analysis. In all, 27,041 patients with PD were matched by gender, age, insured region, urbanization and income, with cases and controls in a 1:4 ratio. Both groups were followed and the risks of SS were calculated by Cox proportional hazards regression. Finally, 3292 (2.4%) patients had newly diagnosed SS. Patients with PD had a significantly higher risk of subsequent SS (903 (3.3%) vs. 2389 (2.2%), adjusted hazard 1.47, 95% confidence interval: 1.36⁻1.59). In conclusion, patients with PD had an approximately 50% increased risk of subsequent SS. Physicians should be aware of the symptoms and signs of SS in patients with PD.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph16050771</identifier><identifier>PMID: 30832451</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Age ; Aged ; Alcoholism ; Autoimmune diseases ; Blood diseases ; Cardiovascular disease ; Cohort analysis ; Cohort Studies ; Confidence intervals ; Coronary artery ; Coronary artery disease ; Databases, Factual ; Diabetes ; Diabetes mellitus ; Drug abuse ; Female ; Gender ; Gum disease ; Health hazards ; Heart diseases ; Humans ; Hyperlipidemia ; Hypertension ; Incidence ; Inflammation ; Low income groups ; Male ; Middle Aged ; National Health Programs - statistics & numerical data ; Oral hygiene ; Patients ; Periodontal disease ; Periodontal diseases ; Periodontal Diseases - epidemiology ; Population studies ; Population-based studies ; Risk ; Sjogren's Syndrome - epidemiology ; Smoking ; Software ; Stroke ; Studies ; Systemic diseases ; Taiwan - epidemiology ; Tobacco ; Urbanization ; Xerostomia - epidemiology</subject><ispartof>International journal of environmental research and public health, 2019-03, Vol.16 (5), p.771</ispartof><rights>2019. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-1c51c5766dd3a54979217e765ee982a66632fca2a9c0bee4f7156b72a5d3604d3</citedby><cites>FETCH-LOGICAL-c418t-1c51c5766dd3a54979217e765ee982a66632fca2a9c0bee4f7156b72a5d3604d3</cites><orcidid>0000-0003-4630-8724 ; 0000-0003-1677-8901 ; 0000-0003-3868-085X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427323/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427323/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30832451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Chien-Yu</creatorcontrib><creatorcontrib>Tseng, Chien-Fu</creatorcontrib><creatorcontrib>Liu, Jui-Ming</creatorcontrib><creatorcontrib>Chuang, Heng-Chang</creatorcontrib><creatorcontrib>Lei, Wei-Te</creatorcontrib><creatorcontrib>Liu, Lawrence Yu-Min</creatorcontrib><creatorcontrib>Yu, Yu-Chin</creatorcontrib><creatorcontrib>Hsu, Ren-Jun</creatorcontrib><title>Association between Periodontal Disease and Subsequent Sjögren's Syndrome: A Nationwide Population-Based Cohort Study</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Xerostomia (dry mouth) is the cardinal symptom of Sjögren's syndrome (SS), which is an autoimmune disease involving the exocrine glands and other organs. Xerostomia may predispose patients to periodontal disease (PD) and an association between SS and PD has been reported. This association may be bidirectional; therefore, we conducted this study to investigate the risk of SS in patients with PD using data from the National Health Insurance Research Database of Taiwan. A total of 135,190 patients were enrolled in our analysis. In all, 27,041 patients with PD were matched by gender, age, insured region, urbanization and income, with cases and controls in a 1:4 ratio. Both groups were followed and the risks of SS were calculated by Cox proportional hazards regression. Finally, 3292 (2.4%) patients had newly diagnosed SS. Patients with PD had a significantly higher risk of subsequent SS (903 (3.3%) vs. 2389 (2.2%), adjusted hazard 1.47, 95% confidence interval: 1.36⁻1.59). In conclusion, patients with PD had an approximately 50% increased risk of subsequent SS. Physicians should be aware of the symptoms and signs of SS in patients with PD.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Alcoholism</subject><subject>Autoimmune diseases</subject><subject>Blood diseases</subject><subject>Cardiovascular disease</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Confidence intervals</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Databases, Factual</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Drug abuse</subject><subject>Female</subject><subject>Gender</subject><subject>Gum disease</subject><subject>Health hazards</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Hyperlipidemia</subject><subject>Hypertension</subject><subject>Incidence</subject><subject>Inflammation</subject><subject>Low income groups</subject><subject>Male</subject><subject>Middle Aged</subject><subject>National Health Programs - statistics & numerical data</subject><subject>Oral hygiene</subject><subject>Patients</subject><subject>Periodontal disease</subject><subject>Periodontal diseases</subject><subject>Periodontal Diseases - epidemiology</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Risk</subject><subject>Sjogren's Syndrome - epidemiology</subject><subject>Smoking</subject><subject>Software</subject><subject>Stroke</subject><subject>Studies</subject><subject>Systemic diseases</subject><subject>Taiwan - epidemiology</subject><subject>Tobacco</subject><subject>Urbanization</subject><subject>Xerostomia - epidemiology</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkV1LHDEYhYNY_GpveykBL-rNaL4mmfGisG5tFaQVtr0Omcm7bpbZZE1mlP1j_oH-MVN3KyoEkpec9-EcDkKfKTnhvCanbg5xOaOSlEQpuoX2qJSkEJLQ7VfvXbSf0pwQXglZ76BdTirOREn30P0opdA607vgcQP9A4DHNxBdsMH3psPfXAKTABtv8WRoEtwN4Hs8mf99vI3gvyQ8WXkbwwLO8Aj_fAY9OAv4JiyH7nkszjPA4nGYhZg3-8GuPqIPU9Ml-LS5D9Cf7xe_x5fF9a8fV-PRddEKWvUFbct8lJTWclOKWtWMKlCyBKgrZqSUnE1bw0zdkgZATBUtZaOYKS2XRFh-gL6uucuhWYBts_VoOr2MbmHiSgfj9Nsf72b6NtxrKZjijGfA8QYQQ06eer1wqYWuMx7CkDSjVcVItiGy9OiddB6G6HM8zTirKaGKqKw6WavaGFKKMH0xQ4n-V6l-W2leOHwd4UX-v0P-BOJQoAU</recordid><startdate>20190303</startdate><enddate>20190303</enddate><creator>Lin, Chien-Yu</creator><creator>Tseng, Chien-Fu</creator><creator>Liu, Jui-Ming</creator><creator>Chuang, Heng-Chang</creator><creator>Lei, Wei-Te</creator><creator>Liu, Lawrence Yu-Min</creator><creator>Yu, Yu-Chin</creator><creator>Hsu, Ren-Jun</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4630-8724</orcidid><orcidid>https://orcid.org/0000-0003-1677-8901</orcidid><orcidid>https://orcid.org/0000-0003-3868-085X</orcidid></search><sort><creationdate>20190303</creationdate><title>Association between Periodontal Disease and Subsequent Sjögren's Syndrome: A Nationwide Population-Based Cohort Study</title><author>Lin, Chien-Yu ; Tseng, Chien-Fu ; Liu, Jui-Ming ; Chuang, Heng-Chang ; Lei, Wei-Te ; Liu, Lawrence Yu-Min ; Yu, Yu-Chin ; Hsu, Ren-Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-1c51c5766dd3a54979217e765ee982a66632fca2a9c0bee4f7156b72a5d3604d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Alcoholism</topic><topic>Autoimmune diseases</topic><topic>Blood diseases</topic><topic>Cardiovascular disease</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Confidence intervals</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Databases, Factual</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Drug abuse</topic><topic>Female</topic><topic>Gender</topic><topic>Gum disease</topic><topic>Health hazards</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Hyperlipidemia</topic><topic>Hypertension</topic><topic>Incidence</topic><topic>Inflammation</topic><topic>Low income groups</topic><topic>Male</topic><topic>Middle Aged</topic><topic>National Health Programs - statistics & numerical data</topic><topic>Oral hygiene</topic><topic>Patients</topic><topic>Periodontal disease</topic><topic>Periodontal diseases</topic><topic>Periodontal Diseases - epidemiology</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Risk</topic><topic>Sjogren's Syndrome - epidemiology</topic><topic>Smoking</topic><topic>Software</topic><topic>Stroke</topic><topic>Studies</topic><topic>Systemic diseases</topic><topic>Taiwan - epidemiology</topic><topic>Tobacco</topic><topic>Urbanization</topic><topic>Xerostomia - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Chien-Yu</creatorcontrib><creatorcontrib>Tseng, Chien-Fu</creatorcontrib><creatorcontrib>Liu, Jui-Ming</creatorcontrib><creatorcontrib>Chuang, Heng-Chang</creatorcontrib><creatorcontrib>Lei, Wei-Te</creatorcontrib><creatorcontrib>Liu, Lawrence Yu-Min</creatorcontrib><creatorcontrib>Yu, Yu-Chin</creatorcontrib><creatorcontrib>Hsu, Ren-Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Chien-Yu</au><au>Tseng, Chien-Fu</au><au>Liu, Jui-Ming</au><au>Chuang, Heng-Chang</au><au>Lei, Wei-Te</au><au>Liu, Lawrence Yu-Min</au><au>Yu, Yu-Chin</au><au>Hsu, Ren-Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Periodontal Disease and Subsequent Sjögren's Syndrome: A Nationwide Population-Based Cohort Study</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2019-03-03</date><risdate>2019</risdate><volume>16</volume><issue>5</issue><spage>771</spage><pages>771-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Xerostomia (dry mouth) is the cardinal symptom of Sjögren's syndrome (SS), which is an autoimmune disease involving the exocrine glands and other organs. Xerostomia may predispose patients to periodontal disease (PD) and an association between SS and PD has been reported. This association may be bidirectional; therefore, we conducted this study to investigate the risk of SS in patients with PD using data from the National Health Insurance Research Database of Taiwan. A total of 135,190 patients were enrolled in our analysis. In all, 27,041 patients with PD were matched by gender, age, insured region, urbanization and income, with cases and controls in a 1:4 ratio. Both groups were followed and the risks of SS were calculated by Cox proportional hazards regression. Finally, 3292 (2.4%) patients had newly diagnosed SS. Patients with PD had a significantly higher risk of subsequent SS (903 (3.3%) vs. 2389 (2.2%), adjusted hazard 1.47, 95% confidence interval: 1.36⁻1.59). In conclusion, patients with PD had an approximately 50% increased risk of subsequent SS. Physicians should be aware of the symptoms and signs of SS in patients with PD.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30832451</pmid><doi>10.3390/ijerph16050771</doi><orcidid>https://orcid.org/0000-0003-4630-8724</orcidid><orcidid>https://orcid.org/0000-0003-1677-8901</orcidid><orcidid>https://orcid.org/0000-0003-3868-085X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; PubMed Central Open Access |
| subjects | Adult Age Aged Alcoholism Autoimmune diseases Blood diseases Cardiovascular disease Cohort analysis Cohort Studies Confidence intervals Coronary artery Coronary artery disease Databases, Factual Diabetes Diabetes mellitus Drug abuse Female Gender Gum disease Health hazards Heart diseases Humans Hyperlipidemia Hypertension Incidence Inflammation Low income groups Male Middle Aged National Health Programs - statistics & numerical data Oral hygiene Patients Periodontal disease Periodontal diseases Periodontal Diseases - epidemiology Population studies Population-based studies Risk Sjogren's Syndrome - epidemiology Smoking Software Stroke Studies Systemic diseases Taiwan - epidemiology Tobacco Urbanization Xerostomia - epidemiology |
| title | Association between Periodontal Disease and Subsequent Sjögren's Syndrome: A Nationwide Population-Based Cohort Study |
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