Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer

Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) are important components of the tumor microenvironment, which have been reported to localize in colorectal carcinomas where they promote tumor progression. One of the crucial effects they exerted is immune-suppression, whic...

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Veröffentlicht in:	Cell death & disease 2019-03, Vol.10 (4), p.273-273, Article 273
Hauptverfasser:	Zhang, Rongsheng, Qi, Fan, Zhao, Fei, Li, Geng, Shao, Shengli, Zhang, Xiaochao, Yuan, Lifei, Feng, Yongdong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/21 13/31 13/51 13/89 14/1 14/34 38/22 38/44 38/77 631/250/98 631/67/327 Animals Antibodies Biochemistry Biomedical and Life Sciences Cancer-Associated Fibroblasts - metabolism Cell Adhesion Cell Biology Cell Culture Cell Line, Tumor Cell Movement Cell Polarity Coculture Techniques Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Fibroblasts Gene Knockdown Techniques Heterografts Humans Immunology Interleukin 8 Interleukin-8 - metabolism Killer Cells, Natural - immunology Life Sciences Macrophages Macrophages - metabolism Metastases Mice Mice, Inbred BALB C Monocytes Monocytes - metabolism Natural killer cells SDF-1 protein Synergism Tumor Burden - genetics Tumor cells Vascular cell adhesion molecule 1 Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - metabolism
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