Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network
While children approaching end-stage kidney disease (ESKD) are considered at risk of uremic anorexia and underweight they are also exposed to the global obesity epidemic. We sought to investigate the variation of nutritional status in children undergoing chronic peritoneal dialysis (CPD) around the...
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| Veröffentlicht in: | Scientific reports 2019-03, Vol.9 (1), p.4886-4886, Article 4886 |
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| creator | Schaefer, Franz Benner, Laura Borzych-Dużałka, Dagmara Zaritsky, Joshua Xu, Hong Rees, Lesley Antonio, Zenaida L. Serdaroglu, Erkin Hooman, Nakysa Patel, Hiren Sever, Lale Vondrak, Karel Flynn, Joseph Rébori, Anabella Wong, William Hölttä, Tuula Yildirim, Zeynep Yuruk Ranchin, Bruno Grenda, Ryszard Testa, Sara Drożdz, Dorota Szabo, Attila J. Eid, Loai Basu, Biswanath Vitkevic, Renata Wong, Cynthia Pottoore, Stephen J. Müller, Dominik Dusunsel, Ruhan Celedon, Claudia Gonzalez Fila, Marc Sartz, Lisa Sander, Anja Warady, Bradley A. |
| description | While children approaching end-stage kidney disease (ESKD) are considered at risk of uremic anorexia and underweight they are also exposed to the global obesity epidemic. We sought to investigate the variation of nutritional status in children undergoing chronic peritoneal dialysis (CPD) around the globe. The distribution and course of body mass index (BMI) standard deviation score over time was examined prospectively in 1001 children and adolescents from 35 countries starting CPD who were followed in the International Pediatric PD Network (IPPN) Registry. The overall prevalence of underweight, and overweight/obesity at start of CPD was 8.9% and 19.7%, respectively. Underweight was most prevalent in South and Southeast Asia (20%), Central Europe (16.7%) and Turkey (15.2%), whereas overweight and obesity were most common in the Middle East (40%) and the US (33%). BMI SDS at PD initiation was associated positively with current eGFR and gastrostomy feeding prior to PD start. Over the course of PD BMI SDS tended to increase on CPD in underweight and normal weight children, whereas it decreased in initially overweight patients. In infancy, mortality risk was amplified by obesity, whereas in older children mortality was markedly increased in association with underweight. Both underweight and overweight are prevalent in pediatric ESKD, with the prevalence varying across the globe. Late dialysis start is associated with underweight, while enteral feeding can lead to obesity. Nutritional abnormalities tend to attenuate with time on dialysis. Mortality risk appears increased with obesity in infants and with underweight in older children. |
| doi_str_mv | 10.1038/s41598-018-36975-z |
| format | Article |
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We sought to investigate the variation of nutritional status in children undergoing chronic peritoneal dialysis (CPD) around the globe. The distribution and course of body mass index (BMI) standard deviation score over time was examined prospectively in 1001 children and adolescents from 35 countries starting CPD who were followed in the International Pediatric PD Network (IPPN) Registry. The overall prevalence of underweight, and overweight/obesity at start of CPD was 8.9% and 19.7%, respectively. Underweight was most prevalent in South and Southeast Asia (20%), Central Europe (16.7%) and Turkey (15.2%), whereas overweight and obesity were most common in the Middle East (40%) and the US (33%). BMI SDS at PD initiation was associated positively with current eGFR and gastrostomy feeding prior to PD start. Over the course of PD BMI SDS tended to increase on CPD in underweight and normal weight children, whereas it decreased in initially overweight patients. In infancy, mortality risk was amplified by obesity, whereas in older children mortality was markedly increased in association with underweight. Both underweight and overweight are prevalent in pediatric ESKD, with the prevalence varying across the globe. Late dialysis start is associated with underweight, while enteral feeding can lead to obesity. Nutritional abnormalities tend to attenuate with time on dialysis. Mortality risk appears increased with obesity in infants and with underweight in older children.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-36975-z</identifier><identifier>PMID: 30894599</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/174 ; 692/4022/1950/1724 ; Adolescent ; Adolescents ; Americas ; Anorexia ; Asia ; Body mass index ; Body weight ; Child ; Child, Preschool ; Children ; Dialysis ; Eating disorders ; End-stage renal disease ; Enteral feeding ; Enteral nutrition ; Enteral Nutrition - adverse effects ; Epidermal growth factor receptors ; Europe ; Female ; Health risks ; Humanities and Social Sciences ; Humans ; Infant ; Infants ; Kidney diseases ; Kidney Failure, Chronic - epidemiology ; Kidney Failure, Chronic - therapy ; Longitudinal Studies ; Male ; Mortality ; Mortality risk ; multidisciplinary ; Nutritional Status ; Obesity ; Ostomy ; Overweight ; Overweight - epidemiology ; Pediatric Obesity - epidemiology ; Pediatrics ; Peritoneal dialysis ; Peritoneal Dialysis - mortality ; Peritoneum ; Prevalence ; Registries ; Risk Factors ; Science ; Science (multidisciplinary) ; Thinness - epidemiology ; Underweight</subject><ispartof>Scientific reports, 2019-03, Vol.9 (1), p.4886-4886, Article 4886</ispartof><rights>The Author(s) 2019</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-604e12ca345457efffdf63d9c08f071c890af322051e48db135e82dd58d0c0af3</citedby><cites>FETCH-LOGICAL-c522t-604e12ca345457efffdf63d9c08f071c890af322051e48db135e82dd58d0c0af3</cites><orcidid>0000-0001-8857-7100 ; 0000-0002-8494-947X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426856/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426856/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30894599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schaefer, Franz</creatorcontrib><creatorcontrib>Benner, Laura</creatorcontrib><creatorcontrib>Borzych-Dużałka, Dagmara</creatorcontrib><creatorcontrib>Zaritsky, Joshua</creatorcontrib><creatorcontrib>Xu, Hong</creatorcontrib><creatorcontrib>Rees, Lesley</creatorcontrib><creatorcontrib>Antonio, Zenaida L.</creatorcontrib><creatorcontrib>Serdaroglu, Erkin</creatorcontrib><creatorcontrib>Hooman, Nakysa</creatorcontrib><creatorcontrib>Patel, Hiren</creatorcontrib><creatorcontrib>Sever, Lale</creatorcontrib><creatorcontrib>Vondrak, Karel</creatorcontrib><creatorcontrib>Flynn, Joseph</creatorcontrib><creatorcontrib>Rébori, Anabella</creatorcontrib><creatorcontrib>Wong, William</creatorcontrib><creatorcontrib>Hölttä, Tuula</creatorcontrib><creatorcontrib>Yildirim, Zeynep Yuruk</creatorcontrib><creatorcontrib>Ranchin, Bruno</creatorcontrib><creatorcontrib>Grenda, Ryszard</creatorcontrib><creatorcontrib>Testa, Sara</creatorcontrib><creatorcontrib>Drożdz, Dorota</creatorcontrib><creatorcontrib>Szabo, Attila J.</creatorcontrib><creatorcontrib>Eid, Loai</creatorcontrib><creatorcontrib>Basu, Biswanath</creatorcontrib><creatorcontrib>Vitkevic, Renata</creatorcontrib><creatorcontrib>Wong, Cynthia</creatorcontrib><creatorcontrib>Pottoore, Stephen J.</creatorcontrib><creatorcontrib>Müller, Dominik</creatorcontrib><creatorcontrib>Dusunsel, Ruhan</creatorcontrib><creatorcontrib>Celedon, Claudia Gonzalez</creatorcontrib><creatorcontrib>Fila, Marc</creatorcontrib><creatorcontrib>Sartz, Lisa</creatorcontrib><creatorcontrib>Sander, Anja</creatorcontrib><creatorcontrib>Warady, Bradley A.</creatorcontrib><creatorcontrib>International Pediatric Peritoneal Dialysis Network (IPPN) Registry</creatorcontrib><title>Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>While children approaching end-stage kidney disease (ESKD) are considered at risk of uremic anorexia and underweight they are also exposed to the global obesity epidemic. We sought to investigate the variation of nutritional status in children undergoing chronic peritoneal dialysis (CPD) around the globe. The distribution and course of body mass index (BMI) standard deviation score over time was examined prospectively in 1001 children and adolescents from 35 countries starting CPD who were followed in the International Pediatric PD Network (IPPN) Registry. The overall prevalence of underweight, and overweight/obesity at start of CPD was 8.9% and 19.7%, respectively. Underweight was most prevalent in South and Southeast Asia (20%), Central Europe (16.7%) and Turkey (15.2%), whereas overweight and obesity were most common in the Middle East (40%) and the US (33%). BMI SDS at PD initiation was associated positively with current eGFR and gastrostomy feeding prior to PD start. Over the course of PD BMI SDS tended to increase on CPD in underweight and normal weight children, whereas it decreased in initially overweight patients. In infancy, mortality risk was amplified by obesity, whereas in older children mortality was markedly increased in association with underweight. Both underweight and overweight are prevalent in pediatric ESKD, with the prevalence varying across the globe. Late dialysis start is associated with underweight, while enteral feeding can lead to obesity. Nutritional abnormalities tend to attenuate with time on dialysis. Mortality risk appears increased with obesity in infants and with underweight in older children.</description><subject>692/308/174</subject><subject>692/4022/1950/1724</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Americas</subject><subject>Anorexia</subject><subject>Asia</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Dialysis</subject><subject>Eating disorders</subject><subject>End-stage renal disease</subject><subject>Enteral feeding</subject><subject>Enteral nutrition</subject><subject>Enteral Nutrition - adverse effects</subject><subject>Epidermal growth factor receptors</subject><subject>Europe</subject><subject>Female</subject><subject>Health risks</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Kidney diseases</subject><subject>Kidney 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(Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central 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Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schaefer, Franz</au><au>Benner, Laura</au><au>Borzych-Dużałka, Dagmara</au><au>Zaritsky, Joshua</au><au>Xu, Hong</au><au>Rees, Lesley</au><au>Antonio, Zenaida L.</au><au>Serdaroglu, Erkin</au><au>Hooman, Nakysa</au><au>Patel, Hiren</au><au>Sever, Lale</au><au>Vondrak, Karel</au><au>Flynn, Joseph</au><au>Rébori, Anabella</au><au>Wong, William</au><au>Hölttä, Tuula</au><au>Yildirim, Zeynep Yuruk</au><au>Ranchin, Bruno</au><au>Grenda, Ryszard</au><au>Testa, Sara</au><au>Drożdz, Dorota</au><au>Szabo, Attila J.</au><au>Eid, Loai</au><au>Basu, Biswanath</au><au>Vitkevic, Renata</au><au>Wong, Cynthia</au><au>Pottoore, Stephen J.</au><au>Müller, Dominik</au><au>Dusunsel, Ruhan</au><au>Celedon, Claudia Gonzalez</au><au>Fila, Marc</au><au>Sartz, Lisa</au><au>Sander, Anja</au><au>Warady, Bradley A.</au><aucorp>International Pediatric Peritoneal Dialysis Network (IPPN) Registry</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-03-20</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>4886</spage><epage>4886</epage><pages>4886-4886</pages><artnum>4886</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>While children approaching end-stage kidney disease (ESKD) are considered at risk of uremic anorexia and underweight they are also exposed to the global obesity epidemic. We sought to investigate the variation of nutritional status in children undergoing chronic peritoneal dialysis (CPD) around the globe. The distribution and course of body mass index (BMI) standard deviation score over time was examined prospectively in 1001 children and adolescents from 35 countries starting CPD who were followed in the International Pediatric PD Network (IPPN) Registry. The overall prevalence of underweight, and overweight/obesity at start of CPD was 8.9% and 19.7%, respectively. Underweight was most prevalent in South and Southeast Asia (20%), Central Europe (16.7%) and Turkey (15.2%), whereas overweight and obesity were most common in the Middle East (40%) and the US (33%). BMI SDS at PD initiation was associated positively with current eGFR and gastrostomy feeding prior to PD start. Over the course of PD BMI SDS tended to increase on CPD in underweight and normal weight children, whereas it decreased in initially overweight patients. In infancy, mortality risk was amplified by obesity, whereas in older children mortality was markedly increased in association with underweight. Both underweight and overweight are prevalent in pediatric ESKD, with the prevalence varying across the globe. Late dialysis start is associated with underweight, while enteral feeding can lead to obesity. Nutritional abnormalities tend to attenuate with time on dialysis. Mortality risk appears increased with obesity in infants and with underweight in older children.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30894599</pmid><doi>10.1038/s41598-018-36975-z</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-8857-7100</orcidid><orcidid>https://orcid.org/0000-0002-8494-947X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2019-03, Vol.9 (1), p.4886-4886, Article 4886 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6426856 |
| source | Nature Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; Springer Nature OA Free Journals |
| subjects | 692/308/174 692/4022/1950/1724 Adolescent Adolescents Americas Anorexia Asia Body mass index Body weight Child Child, Preschool Children Dialysis Eating disorders End-stage renal disease Enteral feeding Enteral nutrition Enteral Nutrition - adverse effects Epidermal growth factor receptors Europe Female Health risks Humanities and Social Sciences Humans Infant Infants Kidney diseases Kidney Failure, Chronic - epidemiology Kidney Failure, Chronic - therapy Longitudinal Studies Male Mortality Mortality risk multidisciplinary Nutritional Status Obesity Ostomy Overweight Overweight - epidemiology Pediatric Obesity - epidemiology Pediatrics Peritoneal dialysis Peritoneal Dialysis - mortality Peritoneum Prevalence Registries Risk Factors Science Science (multidisciplinary) Thinness - epidemiology Underweight |
| title | Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network |
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