Impeding DNA Break Repair Enables Oocyte Quality Control

Oocyte quality control culls eggs with defects in meiosis. In mouse, oocyte death can be triggered by defects in chromosome synapsis and recombination, which involve repair of DNA double-strand breaks (DSBs) between homologous chromosomes. We show that RNF212, a SUMO ligase required for crossing ove...

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Veröffentlicht in:	Molecular cell 2018-10, Vol.72 (2), p.211-221.e3
Hauptverfasser:	Qiao, Huanyu, Rao, H.B.D. Prasada, Yun, Yan, Sandhu, Sumit, Fong, Jared H., Sapre, Manali, Nguyen, Michael, Tham, Addy, Van, Benjamin W., Chng, Tiffany Y.H., Lee, Amy, Hunter, Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis attrition Cell Cycle Proteins - genetics chromosome pairing Chromosome Pairing - genetics chromosomes DNA Breaks, Double-Stranded DNA damage DNA Damage - genetics DNA repair DNA Repair - genetics double strand break eggs Female follicle genome homologous recombination HORMAD ligases Ligases - genetics Male meiosis Meiosis - genetics Mice mutants oocyte oocytes Oocytes - physiology Quality Control Recombination, Genetic - genetics RNF212 SUMO
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