Additive effectiveness of autologous platelet-rich fibrin in the treatment of intrabony defects: A PRISMA-compliant meta-analysis
This meta-analysis was performed to determine the additive effectiveness of autologous platelet-rich fibrin in the treatment of intrabony defects in chronic periodontitis patients. Pertinent studies were identified by a search in Medline, EMBASE, the Web of Science, and the Cochrane Library. The tri...
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| Veröffentlicht in: | Medicine (Baltimore) 2019-03, Vol.98 (11), p.e14759-e14759 |
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| creator | Li, Ang Yang, Hongjie Zhang, Jingyi Chen, Shulian Wang, Hongqiang Gao, Yanzheng |
| description | This meta-analysis was performed to determine the additive effectiveness of autologous platelet-rich fibrin in the treatment of intrabony defects in chronic periodontitis patients.
Pertinent studies were identified by a search in Medline, EMBASE, the Web of Science, and the Cochrane Library. The trials searched were evaluated for eligibility. Cochrane Collaboration's Review Manager software was used to perform the meta-analyses.
Twelve eligible clinical trials were included. Pooled data found that adjunctive platelet-rich fibrin exactly yielded a significantly superior probing depth reduction compared with open flap debridement alone (weighted mean difference, 1.01; 95% confidence interval 0.95-1.08; P |
| doi_str_mv | 10.1097/MD.0000000000014759 |
| format | Article |
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Pertinent studies were identified by a search in Medline, EMBASE, the Web of Science, and the Cochrane Library. The trials searched were evaluated for eligibility. Cochrane Collaboration's Review Manager software was used to perform the meta-analyses.
Twelve eligible clinical trials were included. Pooled data found that adjunctive platelet-rich fibrin exactly yielded a significantly superior probing depth reduction compared with open flap debridement alone (weighted mean difference, 1.01; 95% confidence interval 0.95-1.08; P < .00001). The clinical attachment level (CAL) gain after treatment for 9 months was higher in patients treated with platelet-rich fibrin plus open flap debridement group than in open flap debridement-treated patients (weighted mean difference, 1.29; 95% confidence interval 0.96- 1.61; P < .00001). Similarly, the meta-analysis demonstrated that platelet-rich fibrin was superior to single open flap debridement with respect to gingival marginal level change (weighted mean difference, 0.45; 95% confidence interval 0.31-0.58; P < .00001). Regarding the hard tissue radiographic parameters, including defect depth reduction and percentage of fill defects in bone, adjunctive platelet-rich fibrin yielded significantly superior results compared with open flap debridement alone.
Adjunctive use of platelet-rich fibrin with open flap debridement significantly improves fill defects when compared to open flap debridement alone. However, additional powered studies with much larger sample sizes are needed to obtain a more concrete conclusion.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000014759</identifier><identifier>PMID: 30882646</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Chronic Periodontitis - surgery ; Clinical Trials as Topic ; Humans ; Periodontal Debridement ; Platelet-Rich Fibrin ; Systematic Review and Meta-Analysis ; Transplantation, Autologous</subject><ispartof>Medicine (Baltimore), 2019-03, Vol.98 (11), p.e14759-e14759</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3550-e734715c8299e6593c360c540749a9f53660ce519d51cfde0a1fd66b697d72343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426538/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426538/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27913,27914,53780,53782</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30882646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Ang</creatorcontrib><creatorcontrib>Yang, Hongjie</creatorcontrib><creatorcontrib>Zhang, Jingyi</creatorcontrib><creatorcontrib>Chen, Shulian</creatorcontrib><creatorcontrib>Wang, Hongqiang</creatorcontrib><creatorcontrib>Gao, Yanzheng</creatorcontrib><title>Additive effectiveness of autologous platelet-rich fibrin in the treatment of intrabony defects: A PRISMA-compliant meta-analysis</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>This meta-analysis was performed to determine the additive effectiveness of autologous platelet-rich fibrin in the treatment of intrabony defects in chronic periodontitis patients.
Pertinent studies were identified by a search in Medline, EMBASE, the Web of Science, and the Cochrane Library. The trials searched were evaluated for eligibility. Cochrane Collaboration's Review Manager software was used to perform the meta-analyses.
Twelve eligible clinical trials were included. Pooled data found that adjunctive platelet-rich fibrin exactly yielded a significantly superior probing depth reduction compared with open flap debridement alone (weighted mean difference, 1.01; 95% confidence interval 0.95-1.08; P < .00001). The clinical attachment level (CAL) gain after treatment for 9 months was higher in patients treated with platelet-rich fibrin plus open flap debridement group than in open flap debridement-treated patients (weighted mean difference, 1.29; 95% confidence interval 0.96- 1.61; P < .00001). Similarly, the meta-analysis demonstrated that platelet-rich fibrin was superior to single open flap debridement with respect to gingival marginal level change (weighted mean difference, 0.45; 95% confidence interval 0.31-0.58; P < .00001). Regarding the hard tissue radiographic parameters, including defect depth reduction and percentage of fill defects in bone, adjunctive platelet-rich fibrin yielded significantly superior results compared with open flap debridement alone.
Adjunctive use of platelet-rich fibrin with open flap debridement significantly improves fill defects when compared to open flap debridement alone. However, additional powered studies with much larger sample sizes are needed to obtain a more concrete conclusion.</description><subject>Chronic Periodontitis - surgery</subject><subject>Clinical Trials as Topic</subject><subject>Humans</subject><subject>Periodontal Debridement</subject><subject>Platelet-Rich Fibrin</subject><subject>Systematic Review and Meta-Analysis</subject><subject>Transplantation, Autologous</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUVtvFCEYnRiNXau_wMTw6MtUGG6DDyabVmuTbjRengnLfNNBmWEFps0-9p_LuLVeCAkfcM7h8J2qek7wCcFKvtqcneA_gzDJ1YNqRTgVNVeCPaxWGDe8lkqyo-pJSt8KiMqGPa6OKG7bRjCxqm7XXeeyuwYEfQ92qSZICYUemTkHH67CnNDOmwwech2dHVDvttFNqMw8AMoRTB5hygvHTTmabZj2qINFLr1Ga_Tx08Xnzbq2Ydx5ZwpwhGxqMxm_Ty49rR71xid4drceV1_fvf1y-r6-_HB-cbq-rC3lHNcgKZOE27ZRCgRX1FKBLWdYMmVUX35dtsCJ6jixfQfYkL4TYiuU7GRDGT2u3hx0d_N2hM7CYtXrXXSjiXsdjNP_3kxu0FfhWgvWCE7bIvDyTiCGHzOkrEeXLHhvJihN0g1RxRIXLS1QeoDaGFKK0N8_Q7BewtObM_1_eIX14m-H95zfaRUAOwBugs8Q03c_30DUAxifh196XKqmbjBRmJLStHJCMf0Jgqymhw</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Li, Ang</creator><creator>Yang, Hongjie</creator><creator>Zhang, Jingyi</creator><creator>Chen, Shulian</creator><creator>Wang, Hongqiang</creator><creator>Gao, Yanzheng</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190301</creationdate><title>Additive effectiveness of autologous platelet-rich fibrin in the treatment of intrabony defects: A PRISMA-compliant meta-analysis</title><author>Li, Ang ; Yang, Hongjie ; Zhang, Jingyi ; Chen, Shulian ; Wang, Hongqiang ; Gao, Yanzheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3550-e734715c8299e6593c360c540749a9f53660ce519d51cfde0a1fd66b697d72343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Chronic Periodontitis - surgery</topic><topic>Clinical Trials as Topic</topic><topic>Humans</topic><topic>Periodontal Debridement</topic><topic>Platelet-Rich Fibrin</topic><topic>Systematic Review and Meta-Analysis</topic><topic>Transplantation, Autologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ang</creatorcontrib><creatorcontrib>Yang, Hongjie</creatorcontrib><creatorcontrib>Zhang, Jingyi</creatorcontrib><creatorcontrib>Chen, Shulian</creatorcontrib><creatorcontrib>Wang, Hongqiang</creatorcontrib><creatorcontrib>Gao, Yanzheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ang</au><au>Yang, Hongjie</au><au>Zhang, Jingyi</au><au>Chen, Shulian</au><au>Wang, Hongqiang</au><au>Gao, Yanzheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Additive effectiveness of autologous platelet-rich fibrin in the treatment of intrabony defects: A PRISMA-compliant meta-analysis</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>98</volume><issue>11</issue><spage>e14759</spage><epage>e14759</epage><pages>e14759-e14759</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>This meta-analysis was performed to determine the additive effectiveness of autologous platelet-rich fibrin in the treatment of intrabony defects in chronic periodontitis patients.
Pertinent studies were identified by a search in Medline, EMBASE, the Web of Science, and the Cochrane Library. The trials searched were evaluated for eligibility. Cochrane Collaboration's Review Manager software was used to perform the meta-analyses.
Twelve eligible clinical trials were included. Pooled data found that adjunctive platelet-rich fibrin exactly yielded a significantly superior probing depth reduction compared with open flap debridement alone (weighted mean difference, 1.01; 95% confidence interval 0.95-1.08; P < .00001). The clinical attachment level (CAL) gain after treatment for 9 months was higher in patients treated with platelet-rich fibrin plus open flap debridement group than in open flap debridement-treated patients (weighted mean difference, 1.29; 95% confidence interval 0.96- 1.61; P < .00001). Similarly, the meta-analysis demonstrated that platelet-rich fibrin was superior to single open flap debridement with respect to gingival marginal level change (weighted mean difference, 0.45; 95% confidence interval 0.31-0.58; P < .00001). Regarding the hard tissue radiographic parameters, including defect depth reduction and percentage of fill defects in bone, adjunctive platelet-rich fibrin yielded significantly superior results compared with open flap debridement alone.
Adjunctive use of platelet-rich fibrin with open flap debridement significantly improves fill defects when compared to open flap debridement alone. However, additional powered studies with much larger sample sizes are needed to obtain a more concrete conclusion.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>30882646</pmid><doi>10.1097/MD.0000000000014759</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Chronic Periodontitis - surgery Clinical Trials as Topic Humans Periodontal Debridement Platelet-Rich Fibrin Systematic Review and Meta-Analysis Transplantation, Autologous |
| title | Additive effectiveness of autologous platelet-rich fibrin in the treatment of intrabony defects: A PRISMA-compliant meta-analysis |
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