Mapping the Genetic Landscape of Human Cells

Seminal yeast studies have established the value of comprehensively mapping genetic interactions (GIs) for inferring gene function. Efforts in human cells using focused gene sets underscore the utility of this approach, but the feasibility of generating large-scale, diverse human GI maps remains unr...

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Veröffentlicht in:	Cell 2018-08, Vol.174 (4), p.953-967.e22
Hauptverfasser:	Horlbeck, Max A., Xu, Albert, Wang, Min, Bennett, Neal K., Park, Chong Y., Bogdanoff, Derek, Adamson, Britt, Chow, Eric D., Kampmann, Martin, Peterson, Tim R., Nakamura, Ken, Fischbach, Michael A., Weissman, Jonathan S., Gilbert, Luke A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - metabolism biosynthesis cell lines cholesterol Cholesterol - metabolism Clustered Regularly Interspaced Short Palindromic Repeats CRISPR CRISPRi DNA damage DNA repair electron transport chain epistasis Epistasis, Genetic functional genomics gene editing Gene Regulatory Networks genes genetic interactions High-Throughput Nucleotide Sequencing Humans Jurkat Cells K562 Cells neoplasm cells Protein Interaction Mapping yeasts
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