When size matters: transient receptor potential vanilloid 4 channel as a volume‐sensor rather than an osmo‐sensor

Key points Mammalian cells are frequently exposed to stressors causing volume changes. The transient receptor potential vanilloid 4 (TRPV4) channel translates osmotic stress into ion flux. The molecular mechanism coupling osmolarity to TRPV4 activation remains elusive. TRPV4 responds to isosmolar ce...

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Veröffentlicht in:	The Journal of physiology 2017-06, Vol.595 (11), p.3287-3302
Hauptverfasser:	Toft‐Bertelsen, Trine L., Križaj, David, MacAulay, Nanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals aquaporin Aquaporin 1 Aquaporin 4 Aquaporins Aquaporins - metabolism Calcium (intracellular) Calcium permeability Calcium signalling Cell Size Channel opening Intracellular signalling ion channel Isoforms Macromolecules Magnesium Mammalian cells Metabolites Molecular and cellular Oocytes Osmolarity Osmosis Osmotic Pressure Osmotic stress osmotic swelling osmo‐sensor Rats Research Paper Sensors Signal Transduction Solute Carrier Family 12, Member 2 - metabolism Transient receptor potential proteins transient receptor potential vanilloid 4 (TRPV4) TRP channels TRPV Cation Channels - metabolism volume regulation volume‐sensor water channel Xenopus
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