Bisphenol-A induced oxidative stress, inflammatory gene expression, and metabolic and histopathological changes in male Wistar albino rats: protective role of boron

Bisphenol A (BPA) is one of the most produced chemicals in the world and has been widely employed in the food industry. Continuous and widespread exposure to BPA through drinking water and food leads to health concerns for humans. This study evaluated the effects of boron (B) on BPA-mediated oxidati...

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Veröffentlicht in:Toxicology research (Cambridge) 2019-03, Vol.8 (2), p.262-269
Hauptverfasser: Acaroz, Ulas, Ince, Sinan, Arslan-Acaroz, Damla, Gurler, Zeki, Demirel, Hasan Huseyin, Kucukkurt, Ismail, Eryavuz, Abdullah, Kara, Recep, Varol, Nuray, Zhu, Kui
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container_title Toxicology research (Cambridge)
container_volume 8
creator Acaroz, Ulas
Ince, Sinan
Arslan-Acaroz, Damla
Gurler, Zeki
Demirel, Hasan Huseyin
Kucukkurt, Ismail
Eryavuz, Abdullah
Kara, Recep
Varol, Nuray
Zhu, Kui
description Bisphenol A (BPA) is one of the most produced chemicals in the world and has been widely employed in the food industry. Continuous and widespread exposure to BPA through drinking water and food leads to health concerns for humans. This study evaluated the effects of boron (B) on BPA-mediated oxidative stress in male Wistar albino rats. Rats were equally divided into 5 groups; corn oil was given orally to the control group; 25 mg kg of BPA dissolved in corn oil was given orally to the second group. All other groups received the same dose of BPA and different doses of B (5, 10, and 20 mg kg per day, respectively) orally for 30 days. The administration of BPA significantly decreased glutathione levels and increased malondialdehyde levels in rat tissues. Furthermore, BPA treatment reduced the catalase and superoxide dismutase activities in tissues and erythrocytes. Also, mRNA expression levels of TNF-α, IL-1β, and IL-6 in the brain, liver, and testes of rats were augmented, whereas IL-10 was decreased with BPA treatment. Besides, BPA treatment adversely altered biochemical parameters and caused damage to the cell integrity of rat tissues. However, B administration reversed BPA-induced alterations in rat tissues in a dose-dependent manner. Furthermore, B exhibited antioxidant and anti-inflammatory effects and regulated metabolic and histopathological alterations in male Wistar albino rats exposed to BPA.
doi_str_mv 10.1039/c8tx00312b
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source Oxford University Press Journals All Titles (1996-Current); Royal Society Of Chemistry Journals 2008-; PubMed Central; Alma/SFX Local Collection
subjects Albinism
Antioxidants
Bisphenol A
Boron
Brain
Catalase
Chemistry
Corn
Corn oil
Drinking water
Erythrocytes
Food industry
Food processing industry
Gene expression
Glutathione
IL-1β
Inflammation
Interleukin 10
Interleukin 6
Liver
Malondialdehyde
Metabolism
Organic chemistry
Oxidative stress
Phenols
Superoxide dismutase
Testes
Tissues
Tumor necrosis factor-α
title Bisphenol-A induced oxidative stress, inflammatory gene expression, and metabolic and histopathological changes in male Wistar albino rats: protective role of boron
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