Bisphenol-A induced oxidative stress, inflammatory gene expression, and metabolic and histopathological changes in male Wistar albino rats: protective role of boron
Bisphenol A (BPA) is one of the most produced chemicals in the world and has been widely employed in the food industry. Continuous and widespread exposure to BPA through drinking water and food leads to health concerns for humans. This study evaluated the effects of boron (B) on BPA-mediated oxidati...
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Veröffentlicht in: | Toxicology research (Cambridge) 2019-03, Vol.8 (2), p.262-269 |
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creator | Acaroz, Ulas Ince, Sinan Arslan-Acaroz, Damla Gurler, Zeki Demirel, Hasan Huseyin Kucukkurt, Ismail Eryavuz, Abdullah Kara, Recep Varol, Nuray Zhu, Kui |
description | Bisphenol A (BPA) is one of the most produced chemicals in the world and has been widely employed in the food industry. Continuous and widespread exposure to BPA through drinking water and food leads to health concerns for humans. This study evaluated the effects of boron (B) on BPA-mediated oxidative stress in male Wistar albino rats. Rats were equally divided into 5 groups; corn oil was given orally to the control group; 25 mg kg
of BPA dissolved in corn oil was given orally to the second group. All other groups received the same dose of BPA and different doses of B (5, 10, and 20 mg kg
per day, respectively) orally for 30 days. The administration of BPA significantly decreased glutathione levels and increased malondialdehyde levels in rat tissues. Furthermore, BPA treatment reduced the catalase and superoxide dismutase activities in tissues and erythrocytes. Also, mRNA expression levels of TNF-α, IL-1β, and IL-6 in the brain, liver, and testes of rats were augmented, whereas IL-10 was decreased with BPA treatment. Besides, BPA treatment adversely altered biochemical parameters and caused damage to the cell integrity of rat tissues. However, B administration reversed BPA-induced alterations in rat tissues in a dose-dependent manner. Furthermore, B exhibited antioxidant and anti-inflammatory effects and regulated metabolic and histopathological alterations in male Wistar albino rats exposed to BPA. |
doi_str_mv | 10.1039/c8tx00312b |
format | Article |
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of BPA dissolved in corn oil was given orally to the second group. All other groups received the same dose of BPA and different doses of B (5, 10, and 20 mg kg
per day, respectively) orally for 30 days. The administration of BPA significantly decreased glutathione levels and increased malondialdehyde levels in rat tissues. Furthermore, BPA treatment reduced the catalase and superoxide dismutase activities in tissues and erythrocytes. Also, mRNA expression levels of TNF-α, IL-1β, and IL-6 in the brain, liver, and testes of rats were augmented, whereas IL-10 was decreased with BPA treatment. Besides, BPA treatment adversely altered biochemical parameters and caused damage to the cell integrity of rat tissues. However, B administration reversed BPA-induced alterations in rat tissues in a dose-dependent manner. Furthermore, B exhibited antioxidant and anti-inflammatory effects and regulated metabolic and histopathological alterations in male Wistar albino rats exposed to BPA.</description><identifier>ISSN: 2045-452X</identifier><identifier>EISSN: 2045-4538</identifier><identifier>DOI: 10.1039/c8tx00312b</identifier><identifier>PMID: 30997025</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Albinism ; Antioxidants ; Bisphenol A ; Boron ; Brain ; Catalase ; Chemistry ; Corn ; Corn oil ; Drinking water ; Erythrocytes ; Food industry ; Food processing industry ; Gene expression ; Glutathione ; IL-1β ; Inflammation ; Interleukin 10 ; Interleukin 6 ; Liver ; Malondialdehyde ; Metabolism ; Organic chemistry ; Oxidative stress ; Phenols ; Superoxide dismutase ; Testes ; Tissues ; Tumor necrosis factor-α</subject><ispartof>Toxicology research (Cambridge), 2019-03, Vol.8 (2), p.262-269</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><rights>This journal is © The Royal Society of Chemistry 2019 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-31bb964ff3d6fb54143c82c7972a99bcba3e9508f663d57b43f9448b3dfca95f3</citedby><cites>FETCH-LOGICAL-c406t-31bb964ff3d6fb54143c82c7972a99bcba3e9508f663d57b43f9448b3dfca95f3</cites><orcidid>0000-0002-9257-7506 ; 0000-0002-1915-9797 ; 0000-0001-9230-6725 ; 0000-0002-1533-4519 ; 0000-0002-5002-943X ; 0000-0001-8602-2400 ; 0000-0002-9037-2945 ; 0000-0001-8242-3952 ; 0000-0003-0198-629X ; 0000-0002-4795-2266</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425992/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425992/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30997025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Acaroz, Ulas</creatorcontrib><creatorcontrib>Ince, Sinan</creatorcontrib><creatorcontrib>Arslan-Acaroz, Damla</creatorcontrib><creatorcontrib>Gurler, Zeki</creatorcontrib><creatorcontrib>Demirel, Hasan Huseyin</creatorcontrib><creatorcontrib>Kucukkurt, Ismail</creatorcontrib><creatorcontrib>Eryavuz, Abdullah</creatorcontrib><creatorcontrib>Kara, Recep</creatorcontrib><creatorcontrib>Varol, Nuray</creatorcontrib><creatorcontrib>Zhu, Kui</creatorcontrib><title>Bisphenol-A induced oxidative stress, inflammatory gene expression, and metabolic and histopathological changes in male Wistar albino rats: protective role of boron</title><title>Toxicology research (Cambridge)</title><addtitle>Toxicol Res (Camb)</addtitle><description>Bisphenol A (BPA) is one of the most produced chemicals in the world and has been widely employed in the food industry. Continuous and widespread exposure to BPA through drinking water and food leads to health concerns for humans. This study evaluated the effects of boron (B) on BPA-mediated oxidative stress in male Wistar albino rats. Rats were equally divided into 5 groups; corn oil was given orally to the control group; 25 mg kg
of BPA dissolved in corn oil was given orally to the second group. All other groups received the same dose of BPA and different doses of B (5, 10, and 20 mg kg
per day, respectively) orally for 30 days. The administration of BPA significantly decreased glutathione levels and increased malondialdehyde levels in rat tissues. Furthermore, BPA treatment reduced the catalase and superoxide dismutase activities in tissues and erythrocytes. Also, mRNA expression levels of TNF-α, IL-1β, and IL-6 in the brain, liver, and testes of rats were augmented, whereas IL-10 was decreased with BPA treatment. Besides, BPA treatment adversely altered biochemical parameters and caused damage to the cell integrity of rat tissues. However, B administration reversed BPA-induced alterations in rat tissues in a dose-dependent manner. Furthermore, B exhibited antioxidant and anti-inflammatory effects and regulated metabolic and histopathological alterations in male Wistar albino rats exposed to BPA.</description><subject>Albinism</subject><subject>Antioxidants</subject><subject>Bisphenol A</subject><subject>Boron</subject><subject>Brain</subject><subject>Catalase</subject><subject>Chemistry</subject><subject>Corn</subject><subject>Corn oil</subject><subject>Drinking water</subject><subject>Erythrocytes</subject><subject>Food industry</subject><subject>Food processing industry</subject><subject>Gene expression</subject><subject>Glutathione</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Liver</subject><subject>Malondialdehyde</subject><subject>Metabolism</subject><subject>Organic chemistry</subject><subject>Oxidative stress</subject><subject>Phenols</subject><subject>Superoxide dismutase</subject><subject>Testes</subject><subject>Tissues</subject><subject>Tumor necrosis factor-α</subject><issn>2045-452X</issn><issn>2045-4538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkc9qFTEUxgdRbKnd-AAScCPS0fydmbgotBdbhYKbit2FJJPcSckkY5Jbbt_HBzW9rRc1m5PD9-M75_A1zWsEPyBI-Ec9lC2EBGH1rDnEkLKWMjI83__xzUFznPMtrK-HuCPsZXNAIOe1YYfNr3OXl8mE6Nsz4MK40WYEcetGWdydAbkkk_NJVayX8yxLTPdgbYIBZrs8SC6GEyDDCGZTpIre6V03uVziIssUfVw7LT3Qkwxrk6sTmKU34EclZALSKxciSLLkT2BJsRi9G5xiZaIFKqYYXjUvrPTZHD_Vo-b7xefr1Zf26tvl19XZVasp7EpLkFK8o9aSsbOKUUSJHrDueY8l50orSQxncLBdR0bWK0osp3RQZLRacmbJUXP66Lts1GxGbUJJ0osluVmmexGlE_8qwU1iHe9ERzHjHFeDd08GKf7cmFzE7LI23stg4iYLjBEiuOsRr-jb_9DbuEmhnicwGvpu4AODlXr_SOkUc07G7pdBUDzkL1bD9c0u__MKv_l7_T36J23yG9kMr50</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Acaroz, Ulas</creator><creator>Ince, Sinan</creator><creator>Arslan-Acaroz, Damla</creator><creator>Gurler, Zeki</creator><creator>Demirel, Hasan Huseyin</creator><creator>Kucukkurt, Ismail</creator><creator>Eryavuz, Abdullah</creator><creator>Kara, Recep</creator><creator>Varol, Nuray</creator><creator>Zhu, Kui</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9257-7506</orcidid><orcidid>https://orcid.org/0000-0002-1915-9797</orcidid><orcidid>https://orcid.org/0000-0001-9230-6725</orcidid><orcidid>https://orcid.org/0000-0002-1533-4519</orcidid><orcidid>https://orcid.org/0000-0002-5002-943X</orcidid><orcidid>https://orcid.org/0000-0001-8602-2400</orcidid><orcidid>https://orcid.org/0000-0002-9037-2945</orcidid><orcidid>https://orcid.org/0000-0001-8242-3952</orcidid><orcidid>https://orcid.org/0000-0003-0198-629X</orcidid><orcidid>https://orcid.org/0000-0002-4795-2266</orcidid></search><sort><creationdate>20190301</creationdate><title>Bisphenol-A induced oxidative stress, inflammatory gene expression, and metabolic and histopathological changes in male Wistar albino rats: protective role of boron</title><author>Acaroz, Ulas ; Ince, Sinan ; Arslan-Acaroz, Damla ; Gurler, Zeki ; Demirel, Hasan Huseyin ; Kucukkurt, Ismail ; Eryavuz, Abdullah ; Kara, Recep ; Varol, Nuray ; Zhu, Kui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-31bb964ff3d6fb54143c82c7972a99bcba3e9508f663d57b43f9448b3dfca95f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Albinism</topic><topic>Antioxidants</topic><topic>Bisphenol A</topic><topic>Boron</topic><topic>Brain</topic><topic>Catalase</topic><topic>Chemistry</topic><topic>Corn</topic><topic>Corn oil</topic><topic>Drinking water</topic><topic>Erythrocytes</topic><topic>Food industry</topic><topic>Food processing industry</topic><topic>Gene expression</topic><topic>Glutathione</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Interleukin 10</topic><topic>Interleukin 6</topic><topic>Liver</topic><topic>Malondialdehyde</topic><topic>Metabolism</topic><topic>Organic chemistry</topic><topic>Oxidative stress</topic><topic>Phenols</topic><topic>Superoxide dismutase</topic><topic>Testes</topic><topic>Tissues</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Acaroz, Ulas</creatorcontrib><creatorcontrib>Ince, Sinan</creatorcontrib><creatorcontrib>Arslan-Acaroz, Damla</creatorcontrib><creatorcontrib>Gurler, Zeki</creatorcontrib><creatorcontrib>Demirel, Hasan Huseyin</creatorcontrib><creatorcontrib>Kucukkurt, Ismail</creatorcontrib><creatorcontrib>Eryavuz, Abdullah</creatorcontrib><creatorcontrib>Kara, Recep</creatorcontrib><creatorcontrib>Varol, Nuray</creatorcontrib><creatorcontrib>Zhu, Kui</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Toxicology research (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Acaroz, Ulas</au><au>Ince, Sinan</au><au>Arslan-Acaroz, Damla</au><au>Gurler, Zeki</au><au>Demirel, Hasan Huseyin</au><au>Kucukkurt, Ismail</au><au>Eryavuz, Abdullah</au><au>Kara, Recep</au><au>Varol, Nuray</au><au>Zhu, Kui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bisphenol-A induced oxidative stress, inflammatory gene expression, and metabolic and histopathological changes in male Wistar albino rats: protective role of boron</atitle><jtitle>Toxicology research (Cambridge)</jtitle><addtitle>Toxicol Res (Camb)</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>8</volume><issue>2</issue><spage>262</spage><epage>269</epage><pages>262-269</pages><issn>2045-452X</issn><eissn>2045-4538</eissn><abstract>Bisphenol A (BPA) is one of the most produced chemicals in the world and has been widely employed in the food industry. Continuous and widespread exposure to BPA through drinking water and food leads to health concerns for humans. This study evaluated the effects of boron (B) on BPA-mediated oxidative stress in male Wistar albino rats. Rats were equally divided into 5 groups; corn oil was given orally to the control group; 25 mg kg
of BPA dissolved in corn oil was given orally to the second group. All other groups received the same dose of BPA and different doses of B (5, 10, and 20 mg kg
per day, respectively) orally for 30 days. The administration of BPA significantly decreased glutathione levels and increased malondialdehyde levels in rat tissues. Furthermore, BPA treatment reduced the catalase and superoxide dismutase activities in tissues and erythrocytes. Also, mRNA expression levels of TNF-α, IL-1β, and IL-6 in the brain, liver, and testes of rats were augmented, whereas IL-10 was decreased with BPA treatment. Besides, BPA treatment adversely altered biochemical parameters and caused damage to the cell integrity of rat tissues. However, B administration reversed BPA-induced alterations in rat tissues in a dose-dependent manner. Furthermore, B exhibited antioxidant and anti-inflammatory effects and regulated metabolic and histopathological alterations in male Wistar albino rats exposed to BPA.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>30997025</pmid><doi>10.1039/c8tx00312b</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9257-7506</orcidid><orcidid>https://orcid.org/0000-0002-1915-9797</orcidid><orcidid>https://orcid.org/0000-0001-9230-6725</orcidid><orcidid>https://orcid.org/0000-0002-1533-4519</orcidid><orcidid>https://orcid.org/0000-0002-5002-943X</orcidid><orcidid>https://orcid.org/0000-0001-8602-2400</orcidid><orcidid>https://orcid.org/0000-0002-9037-2945</orcidid><orcidid>https://orcid.org/0000-0001-8242-3952</orcidid><orcidid>https://orcid.org/0000-0003-0198-629X</orcidid><orcidid>https://orcid.org/0000-0002-4795-2266</orcidid><oa>free_for_read</oa></addata></record> |
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source | Oxford University Press Journals All Titles (1996-Current); Royal Society Of Chemistry Journals 2008-; PubMed Central; Alma/SFX Local Collection |
subjects | Albinism Antioxidants Bisphenol A Boron Brain Catalase Chemistry Corn Corn oil Drinking water Erythrocytes Food industry Food processing industry Gene expression Glutathione IL-1β Inflammation Interleukin 10 Interleukin 6 Liver Malondialdehyde Metabolism Organic chemistry Oxidative stress Phenols Superoxide dismutase Testes Tissues Tumor necrosis factor-α |
title | Bisphenol-A induced oxidative stress, inflammatory gene expression, and metabolic and histopathological changes in male Wistar albino rats: protective role of boron |
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