Hyperosmolar Potassium (K+) Treatment Suppresses Osteoarthritic Chondrocyte Catabolic and Inflammatory Protein Production in a 3-Dimensional In Vitro Model

Objective The main goal of this study was to provide a proof-of-concept demonstrating that hyperosmolar K+ solutions can limit production of catabolic and inflammatory mediators in human osteoarthritic chondrocytes (OACs). Methods A 3-dimensional in vitro model with poly(ethylene glycol) diacrylate...

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Veröffentlicht in:	Cartilage 2019-04, Vol.10 (2), p.186-195
Hauptverfasser:	Erndt-Marino, Josh, Trinkle, Erik, Hahn, Mariah S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Research Biomarkers - metabolism Cartilage, Articular - cytology Cartilage, Articular - drug effects Cell Culture Techniques Chondrocytes - drug effects Gluconates - pharmacology Humans Inflammation Mediators - metabolism Osmolar Concentration Osteoarthritis - drug therapy Osteoarthritis - metabolism Potassium - pharmacology Proof of Concept Study Sodium - pharmacology Sucrose - pharmacology
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