Rosmarinic Acid Enriched Fraction from Perilla frutescens Leaves Strongly Protects Indomethacin-Induced Gastric Ulcer in Rats

Gastric ulcers are a common problem in upper gastrointestinal tract (GI) disorders. Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most aggressive factors leading to inducing gastric ulcers. Natural products with lower toxicity and safety are currently sought as a potential source to m...

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Veröffentlicht in:	BioMed research international 2019-01, Vol.2019 (2019), p.1-13
Hauptverfasser:	Suttajit, Maitree, Lekawanvijit, Suree, Pintha, Komsak, Kangwan, Napapan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidity Animals Anti-inflammatory agents Anticancer properties Antioxidants Apoptosis Body weight Chemical compounds Cinnamates - chemistry Cinnamates - pharmacology Cytokines Depsides - chemistry Depsides - pharmacology Dietary supplements Dose-Response Relationship, Drug Drug dosages Ethanol Famotidine Gastrointestinal system Gastrointestinal tract Indomethacin Indomethacin - adverse effects Indomethacin - pharmacology Infiltration Laboratory animals Leaves Male Mucosa Mucus Natural products Nonsteroidal anti-inflammatory drugs Perilla frutescens Perilla frutescens - chemistry Pharmacology Physiology Plant Leaves - chemistry Preservation Product safety Rats Rats, Wistar Rodents Rosmarinic Acid Secretion Stomach Stomach ulcer Stomach Ulcer - chemically induced Stomach Ulcer - pathology Stomach Ulcer - prevention & control Toxicity Ulcers
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