Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice

Dopamine (DA) release in striatum is functionally segregated across a dorsolateral/ventromedial axis. Interestingly, nigrostriatal DA signaling disruption in Parkinson’s disease (PD) preferentially affects the dorsolateral striatum. The relationship between afferent presynaptic calcium transients (P...

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Veröffentlicht in:	Scientific reports 2019-03, Vol.9 (1), p.4857, Article 4857
Hauptverfasser:	Sgobio, Carmelo, Sun, Lixin, Ding, Jinhui, Herms, Jochen, Lovinger, David M., Cai, Huaibin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/44 13/51 14/19 14/35 38/39 631/378/1689/1718 631/378/2632/1323 631/378/548/1964 64/60 9/10 alpha-Synuclein - genetics Animals Basal ganglia Calcium - metabolism Calcium channels Calcium channels (N-type) Calcium Channels - genetics Central nervous system diseases Channel gating Corpus Striatum - metabolism Corpus Striatum - pathology Disease Models, Animal Dopamine Dopamine - genetics Dopamine receptors Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Gene expression Humanities and Social Sciences Humans Laboratories Mesencephalon Mice Mice, Transgenic Movement disorders multidisciplinary Mutation Neostriatum Neostriatum - metabolism Neostriatum - pathology Neurodegeneration Neurodegenerative diseases Nucleus accumbens Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Putamen Science Science (multidisciplinary) Sensory neurons Signal Transduction - genetics Substantia Nigra - metabolism Substantia Nigra - pathology Synuclein Transgenic mice
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