Interactive effects of prenatal alcohol exposure and chronic stress in adulthood on anxiety-like behavior and central stress-related receptor mRNA expression: Sex- and time-dependent effects

•Prenatal alcohol exposure (PAE) increased anxiety-like behavior in males and females.•PAE differentially altered GR mRNA in males and females.•PAE and CUS interact to unmask alterations in GR and CRHR1 mRNA expression in males.•PAE and CUS interact to unmask alterations in MR mRNA expression in fem...

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Veröffentlicht in:	Psychoneuroendocrinology 2018-11, Vol.97, p.8-19
Hauptverfasser:	Lam, Vivian Y.Y., Raineki, Charlis, Ellis, Linda, Yu, Wayne, Weinberg, Joanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety - etiology Anxiety - metabolism Anxiety Disorders - metabolism Anxiety-like behavior Chronic unpredictable stress CRHR1 Depression - etiology Depression - metabolism Depressive Disorder - metabolism Ethanol - adverse effects Ethanol - metabolism Female Hippocampus Hypothalamo-Hypophyseal System - drug effects Male Pituitary-Adrenal System - drug effects Prefrontal Cortex Pregnancy Prenatal alcohol exposure Prenatal Exposure Delayed Effects - physiopathology Rats Rats, Sprague-Dawley Receptors, Corticotropin-Releasing Hormone - analysis Receptors, Corticotropin-Releasing Hormone - drug effects Receptors, Glucocorticoid - analysis Receptors, Glucocorticoid - drug effects Receptors, Mineralocorticoid - analysis Receptors, Mineralocorticoid - drug effects RNA, Messenger Sex Factors Stress, Psychological - etiology Stress, Psychological - physiopathology Time Factors
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