Anti-HIV-1 integrase potency of methylgallate from Alchornea cordifolia using in vitro and in silico approaches

According to the 2018 report of the United Nations Programme on HIV/AIDS (UNAIDS), acquired immune deficiency syndrome (AIDS), a disease caused by the human immunodeficiency virus (HIV), remains a significant public health problem. The non-existence of a cure or effective vaccine for the disease and...

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Veröffentlicht in:	Scientific reports 2019-03, Vol.9 (1), p.4718, Article 4718
Hauptverfasser:	Siwe-Noundou, Xavier, Musyoka, Thommas M., Moses, Vuyani, Ndinteh, Derek T., Mnkandhla, Dumisani, Hoppe, Heinrich, Tastan Bishop, Özlem, Krause, Rui W. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	14/34 140/131 631/154/309/606 631/154/555 Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - virology AIDS Alchornea Antiviral agents Bark Bioactive compounds Cytotoxicity Drug development Drug Evaluation, Preclinical Euphorbiaceae - chemistry Gallic Acid - analogs & derivatives Gallic Acid - chemistry Gallic Acid - isolation & purification Gallic Acid - pharmacology Gallic Acid - therapeutic use HeLa Cells HIV HIV Integrase - metabolism HIV Integrase - ultrastructure HIV Integrase Inhibitors - chemistry HIV Integrase Inhibitors - isolation & purification HIV Integrase Inhibitors - pharmacology HIV Integrase Inhibitors - therapeutic use HIV-1 - drug effects HIV-1 - enzymology Human immunodeficiency virus Humanities and Social Sciences Humans Inhibitory Concentration 50 Integrase Mode of action Molecular Docking Simulation Molecular Dynamics Simulation Molecular modelling multidisciplinary Plant Bark - chemistry Plant Stems - chemistry Protein Domains Public health Recombinant Proteins Science Science (multidisciplinary) Toxicity Tests
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