Recovery from tachyphylaxis of TRPV1 coincides with recycling to the surface membrane

The transient receptor potential vanilloid-1 (TRPV1) ion channel is essential for sensation of thermal and chemical pain. TRPV1 activation is accompanied by Ca2+-dependent desensitization; acute desensitization reflects rapid reduction in channel activity during stimulation, whereas tachyphylaxis de...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-03, Vol.116 (11), p.5170-5175
Hauptverfasser:	Tian, Quan, Hu, Juan, Xie, Chang, Mei, Kaidi, Pham, Cuong, Mo, Xiaoyi, Hepp, Régine, Soares, Sylvia, Nothias, Fatiha, Wang, Yuanyuan, Liu, Qiang, Cai, Fen, Zhong, Bo, Li, Dongdong, Yao, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Calcium (intracellular) Calcium ions Calcium Signaling Calcium signalling Capsaicin receptors Cell Membrane - metabolism Channel gating Desensitization Endocytosis Exocytosis HEK293 Cells Humans Ion channels Kinetics Life Sciences Light Organic chemistry Pain Pain perception pH effects Process control Process controls Protein Transport Protein turnover Rats Stimulation Synaptotagmin Synaptotagmins - metabolism Tachyphylaxis Transient receptor potential proteins TRPV Cation Channels - metabolism
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