Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice

Ketamine is a fast acting experimental antidepressant with significant therapeutic potential for emotional disorders such as major depressive disorder and alcohol use disorders. Of particular interest is binge alcohol use, which during intermittent withdrawal from drinking involves depressive-like s...

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Veröffentlicht in:	Neuropharmacology 2019-05, Vol.149, p.35-44
Hauptverfasser:	Crowley, Nicole A., Magee, Sarah N., Feng, Mengyang, Jefferson, Sarah J., Morris, Christian J., Dao, Nigel C., Brockway, Dakota F., Luscher, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Animals Binge Drinking - metabolism Binge Drinking - therapy Brain - drug effects Brain - metabolism Drinking in the dark Elongation Factor 2 Kinase - metabolism Excitatory Postsynaptic Potentials - drug effects Female Glutamic Acid - metabolism Ketamine Ketamine - pharmacology Male Mice Mice, Inbred C57BL Models, Animal Prefrontal Cortex Prelimbic cortex Receptors, Glutamate - metabolism Signal Transduction - drug effects Synaptic Transmission - drug effects Synaptic Transmission - physiology TOR Serine-Threonine Kinases - metabolism
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