Pistacia vera L. oleoresin and levofloxacin is a synergistic combination against resistant Helicobacter pylori strains
The increasing multidrug resistance in Helicobacter pylori , also correlated to its biofilm‐forming ability, underlines the need to search novel strategies to improve the eradication rate. Natural compounds are proposed as antibiotic-resistant-breakers capable to restore the efficacy of conventional...
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| Veröffentlicht in: | Scientific reports 2019-03, Vol.9 (1), p.4646, Article 4646 |
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| creator | Di Lodovico, Silvia Napoli, Edoardo Di Campli, Emanuela Di Fermo, Paola Gentile, Davide Ruberto, Giuseppe Nostro, Antonia Marini, Emanuela Cellini, Luigina Di Giulio, Mara |
| description | The increasing multidrug resistance in
Helicobacter pylori
, also correlated to its biofilm‐forming ability, underlines the need to search novel strategies to improve the eradication rate. Natural compounds are proposed as antibiotic-resistant-breakers capable to restore the efficacy of conventional drugs. Aim of this work was to evaluate the capability of
Pistacia vera
L. oleoresin (ORS) to synergize with levofloxacin (LVX) against resistant
H
.
pylori
strains. The antimicrobial activity of
P
.
vera
L. ORS and LVX and their combinations was determined by MIC/MBC (in neutral and acidic environments) and checkerboard tests. The anti-biofilm effect was determined by biomass quantification.
In vivo Galleria mellonella
model was used to confirm
in vitro
data.
Pistacia vera
L. ORS and LVX MICs ranged respectively from 780 to 3120 mg/l and from 0.12 to 2.00 mg/l, at pH 7.0 and 5.5. MBCs were similar to MICs.
Pistacia vera
L. ORS was able to synergize with LVX, restoring its effectiveness in LVX resistant strains.
Pistacia vera
L. ORS, LVX and their synergistic combinations displayed significant biofilm reduction.
Pistacia vera
L. ORS and LVX, showed protective effect against
H
.
pylori
infection on
G
.
mellonella
(62% and 63% of survival, respectively).
Pistacia vera
L. ORS can be considered a promising potentiator to restore the effectiveness of LVX tackling the
H
.
pylori
antibiotic resistance phenomenon. |
| doi_str_mv | 10.1038/s41598-019-40991-y |
| format | Article |
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Helicobacter pylori
, also correlated to its biofilm‐forming ability, underlines the need to search novel strategies to improve the eradication rate. Natural compounds are proposed as antibiotic-resistant-breakers capable to restore the efficacy of conventional drugs. Aim of this work was to evaluate the capability of
Pistacia vera
L. oleoresin (ORS) to synergize with levofloxacin (LVX) against resistant
H
.
pylori
strains. The antimicrobial activity of
P
.
vera
L. ORS and LVX and their combinations was determined by MIC/MBC (in neutral and acidic environments) and checkerboard tests. The anti-biofilm effect was determined by biomass quantification.
In vivo Galleria mellonella
model was used to confirm
in vitro
data.
Pistacia vera
L. ORS and LVX MICs ranged respectively from 780 to 3120 mg/l and from 0.12 to 2.00 mg/l, at pH 7.0 and 5.5. MBCs were similar to MICs.
Pistacia vera
L. ORS was able to synergize with LVX, restoring its effectiveness in LVX resistant strains.
Pistacia vera
L. ORS, LVX and their synergistic combinations displayed significant biofilm reduction.
Pistacia vera
L. ORS and LVX, showed protective effect against
H
.
pylori
infection on
G
.
mellonella
(62% and 63% of survival, respectively).
Pistacia vera
L. ORS can be considered a promising potentiator to restore the effectiveness of LVX tackling the
H
.
pylori
antibiotic resistance phenomenon.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-40991-y</identifier><identifier>PMID: 30874618</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14/34 ; 631/326/22/1434 ; 631/326/421 ; 631/326/46 ; 64 ; Anti-Bacterial Agents - pharmacology ; Anti-Infective Agents - pharmacology ; Antibiotic resistance ; Antibiotics ; Antimicrobial activity ; Biofilms ; Biofilms - drug effects ; Drug Resistance, Bacterial - drug effects ; Drug Synergism ; Eradication ; Helicobacter Infections - drug therapy ; Helicobacter pylori ; Helicobacter pylori - drug effects ; Helicobacter pylori - metabolism ; Helicobacter pylori - pathogenicity ; Humanities and Social Sciences ; Humans ; Levofloxacin ; Levofloxacin - pharmacology ; Microbial Sensitivity Tests ; Minimum inhibitory concentration ; multidisciplinary ; Multidrug resistance ; Oleoresins ; Pistacia - metabolism ; Pistacia vera ; Science ; Science (multidisciplinary) ; Synergism</subject><ispartof>Scientific reports, 2019-03, Vol.9 (1), p.4646, Article 4646</ispartof><rights>The Author(s) 2019</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-bbf53911852ec49c2e7f8a5920e67062ddb4c5a5eac0b7067fe051621ee1698c3</citedby><cites>FETCH-LOGICAL-c511t-bbf53911852ec49c2e7f8a5920e67062ddb4c5a5eac0b7067fe051621ee1698c3</cites><orcidid>0000-0001-5311-2848 ; 0000-0003-4068-9124 ; 0000-0002-8375-9404 ; 0000-0003-4281-3256</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420558/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420558/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30874618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Di Lodovico, Silvia</creatorcontrib><creatorcontrib>Napoli, Edoardo</creatorcontrib><creatorcontrib>Di Campli, Emanuela</creatorcontrib><creatorcontrib>Di Fermo, Paola</creatorcontrib><creatorcontrib>Gentile, Davide</creatorcontrib><creatorcontrib>Ruberto, Giuseppe</creatorcontrib><creatorcontrib>Nostro, Antonia</creatorcontrib><creatorcontrib>Marini, Emanuela</creatorcontrib><creatorcontrib>Cellini, Luigina</creatorcontrib><creatorcontrib>Di Giulio, Mara</creatorcontrib><title>Pistacia vera L. oleoresin and levofloxacin is a synergistic combination against resistant Helicobacter pylori strains</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The increasing multidrug resistance in
Helicobacter pylori
, also correlated to its biofilm‐forming ability, underlines the need to search novel strategies to improve the eradication rate. Natural compounds are proposed as antibiotic-resistant-breakers capable to restore the efficacy of conventional drugs. Aim of this work was to evaluate the capability of
Pistacia vera
L. oleoresin (ORS) to synergize with levofloxacin (LVX) against resistant
H
.
pylori
strains. The antimicrobial activity of
P
.
vera
L. ORS and LVX and their combinations was determined by MIC/MBC (in neutral and acidic environments) and checkerboard tests. The anti-biofilm effect was determined by biomass quantification.
In vivo Galleria mellonella
model was used to confirm
in vitro
data.
Pistacia vera
L. ORS and LVX MICs ranged respectively from 780 to 3120 mg/l and from 0.12 to 2.00 mg/l, at pH 7.0 and 5.5. MBCs were similar to MICs.
Pistacia vera
L. ORS was able to synergize with LVX, restoring its effectiveness in LVX resistant strains.
Pistacia vera
L. ORS, LVX and their synergistic combinations displayed significant biofilm reduction.
Pistacia vera
L. ORS and LVX, showed protective effect against
H
.
pylori
infection on
G
.
mellonella
(62% and 63% of survival, respectively).
Pistacia vera
L. ORS can be considered a promising potentiator to restore the effectiveness of LVX tackling the
H
.
pylori
antibiotic resistance phenomenon.</description><subject>14/34</subject><subject>631/326/22/1434</subject><subject>631/326/421</subject><subject>631/326/46</subject><subject>64</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antimicrobial activity</subject><subject>Biofilms</subject><subject>Biofilms - drug effects</subject><subject>Drug Resistance, Bacterial - drug effects</subject><subject>Drug Synergism</subject><subject>Eradication</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - drug effects</subject><subject>Helicobacter pylori - metabolism</subject><subject>Helicobacter pylori - pathogenicity</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Levofloxacin</subject><subject>Levofloxacin - pharmacology</subject><subject>Microbial Sensitivity Tests</subject><subject>Minimum inhibitory concentration</subject><subject>multidisciplinary</subject><subject>Multidrug resistance</subject><subject>Oleoresins</subject><subject>Pistacia - metabolism</subject><subject>Pistacia vera</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Synergism</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUFrGzEQhUVJaYzrP9BDEeS8jka72pUugWCSpmBoD-1ZaOVZV2EtOdLaZP995Dp13Et0kdB8772BR8gXYHNgpbxOFQglCwaqqJhSUIwfyISzShS85Pzi7H1JZik9snwEVxWoT-SyZLKpapATsv_p0mCsM3SP0dDlnIYeQ8TkPDV-RXvch64Pzxnx1CVqaBo9xnVWOUtt2LTOm8GFTK-N82mgB2229AN9wN7Z0Bo7YKTbsQ_R0TTEA_aZfOxMn3D2ek_J7_u7X4uHYvnj2_fF7bKwAmAo2rYTpQKQgqOtlOXYdNIIxRnWDav5atVWVhiBxrI2fzQdMgE1B0SolbTllNwcfbe7doMriz7n93ob3cbEUQfj9P8T7_7oddjruuJMCJkNrl4NYnjaYRr0Y9hFn3fWHBTIkjeqyRQ_UjaGlCJ2pwRg-lCXPtalc136b116zKKv57udJP_KyUB5BFIe-TXGt-x3bF8AlLKkXg</recordid><startdate>20190315</startdate><enddate>20190315</enddate><creator>Di Lodovico, Silvia</creator><creator>Napoli, Edoardo</creator><creator>Di Campli, Emanuela</creator><creator>Di Fermo, Paola</creator><creator>Gentile, Davide</creator><creator>Ruberto, Giuseppe</creator><creator>Nostro, Antonia</creator><creator>Marini, Emanuela</creator><creator>Cellini, Luigina</creator><creator>Di Giulio, Mara</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5311-2848</orcidid><orcidid>https://orcid.org/0000-0003-4068-9124</orcidid><orcidid>https://orcid.org/0000-0002-8375-9404</orcidid><orcidid>https://orcid.org/0000-0003-4281-3256</orcidid></search><sort><creationdate>20190315</creationdate><title>Pistacia vera L. oleoresin and levofloxacin is a synergistic combination against resistant Helicobacter pylori strains</title><author>Di Lodovico, Silvia ; Napoli, Edoardo ; Di Campli, Emanuela ; Di Fermo, Paola ; Gentile, Davide ; Ruberto, Giuseppe ; Nostro, Antonia ; Marini, Emanuela ; Cellini, Luigina ; Di Giulio, Mara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-bbf53911852ec49c2e7f8a5920e67062ddb4c5a5eac0b7067fe051621ee1698c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>14/34</topic><topic>631/326/22/1434</topic><topic>631/326/421</topic><topic>631/326/46</topic><topic>64</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antibiotic resistance</topic><topic>Antibiotics</topic><topic>Antimicrobial activity</topic><topic>Biofilms</topic><topic>Biofilms - drug effects</topic><topic>Drug Resistance, Bacterial - drug effects</topic><topic>Drug Synergism</topic><topic>Eradication</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - drug effects</topic><topic>Helicobacter pylori - metabolism</topic><topic>Helicobacter pylori - pathogenicity</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Levofloxacin</topic><topic>Levofloxacin - pharmacology</topic><topic>Microbial Sensitivity Tests</topic><topic>Minimum inhibitory concentration</topic><topic>multidisciplinary</topic><topic>Multidrug resistance</topic><topic>Oleoresins</topic><topic>Pistacia - metabolism</topic><topic>Pistacia vera</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Synergism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Di Lodovico, Silvia</creatorcontrib><creatorcontrib>Napoli, Edoardo</creatorcontrib><creatorcontrib>Di Campli, Emanuela</creatorcontrib><creatorcontrib>Di Fermo, Paola</creatorcontrib><creatorcontrib>Gentile, Davide</creatorcontrib><creatorcontrib>Ruberto, Giuseppe</creatorcontrib><creatorcontrib>Nostro, Antonia</creatorcontrib><creatorcontrib>Marini, Emanuela</creatorcontrib><creatorcontrib>Cellini, Luigina</creatorcontrib><creatorcontrib>Di Giulio, Mara</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Lodovico, Silvia</au><au>Napoli, Edoardo</au><au>Di Campli, Emanuela</au><au>Di Fermo, Paola</au><au>Gentile, Davide</au><au>Ruberto, Giuseppe</au><au>Nostro, Antonia</au><au>Marini, Emanuela</au><au>Cellini, Luigina</au><au>Di Giulio, Mara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pistacia vera L. oleoresin and levofloxacin is a synergistic combination against resistant Helicobacter pylori strains</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-03-15</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>4646</spage><pages>4646-</pages><artnum>4646</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The increasing multidrug resistance in
Helicobacter pylori
, also correlated to its biofilm‐forming ability, underlines the need to search novel strategies to improve the eradication rate. Natural compounds are proposed as antibiotic-resistant-breakers capable to restore the efficacy of conventional drugs. Aim of this work was to evaluate the capability of
Pistacia vera
L. oleoresin (ORS) to synergize with levofloxacin (LVX) against resistant
H
.
pylori
strains. The antimicrobial activity of
P
.
vera
L. ORS and LVX and their combinations was determined by MIC/MBC (in neutral and acidic environments) and checkerboard tests. The anti-biofilm effect was determined by biomass quantification.
In vivo Galleria mellonella
model was used to confirm
in vitro
data.
Pistacia vera
L. ORS and LVX MICs ranged respectively from 780 to 3120 mg/l and from 0.12 to 2.00 mg/l, at pH 7.0 and 5.5. MBCs were similar to MICs.
Pistacia vera
L. ORS was able to synergize with LVX, restoring its effectiveness in LVX resistant strains.
Pistacia vera
L. ORS, LVX and their synergistic combinations displayed significant biofilm reduction.
Pistacia vera
L. ORS and LVX, showed protective effect against
H
.
pylori
infection on
G
.
mellonella
(62% and 63% of survival, respectively).
Pistacia vera
L. ORS can be considered a promising potentiator to restore the effectiveness of LVX tackling the
H
.
pylori
antibiotic resistance phenomenon.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30874618</pmid><doi>10.1038/s41598-019-40991-y</doi><orcidid>https://orcid.org/0000-0001-5311-2848</orcidid><orcidid>https://orcid.org/0000-0003-4068-9124</orcidid><orcidid>https://orcid.org/0000-0002-8375-9404</orcidid><orcidid>https://orcid.org/0000-0003-4281-3256</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Scientific reports, 2019-03, Vol.9 (1), p.4646, Article 4646 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6420558 |
| source | MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; Springer Nature OA Free Journals |
| subjects | 14/34 631/326/22/1434 631/326/421 631/326/46 64 Anti-Bacterial Agents - pharmacology Anti-Infective Agents - pharmacology Antibiotic resistance Antibiotics Antimicrobial activity Biofilms Biofilms - drug effects Drug Resistance, Bacterial - drug effects Drug Synergism Eradication Helicobacter Infections - drug therapy Helicobacter pylori Helicobacter pylori - drug effects Helicobacter pylori - metabolism Helicobacter pylori - pathogenicity Humanities and Social Sciences Humans Levofloxacin Levofloxacin - pharmacology Microbial Sensitivity Tests Minimum inhibitory concentration multidisciplinary Multidrug resistance Oleoresins Pistacia - metabolism Pistacia vera Science Science (multidisciplinary) Synergism |
| title | Pistacia vera L. oleoresin and levofloxacin is a synergistic combination against resistant Helicobacter pylori strains |
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