A non-canonical JAGGED1 signal to JAK2 mediates osteoblast commitment in cranial neural crest cells

During craniofacial development, cranial neural crest (CNC) cells migrate into the developing face and form bone through intramembranous ossification. Loss of JAGGED1 (JAG1) signaling in the CNC cells is associated with maxillary hypoplasia or maxillary bone deficiency (MBD) in mice and recapitulate...

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Veröffentlicht in:	Cellular signalling 2019-02, Vol.54, p.130-138
Hauptverfasser:	Kamalakar, Archana, Oh, Melissa S., Stephenson, Yvonne C., Ballestas-Naissir, Samir A., Davis, Michael E., Willett, Nick J., Drissi, Hicham M., Goudy, Steven L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcification, Physiologic - physiology Cells, Cultured Jagged-1 Protein - pharmacology Jagged-1 Protein - physiology JAK2 Janus Kinase 2 - physiology Maxillary bone disease Maxillary development Maxillofacial Development - physiology Mice Neural Crest - cytology Neural Crest - metabolism Non-canonical JAGGED1 signaling Osteoblast commitment Osteoblasts - cytology Osteoblasts - metabolism Osteogenesis - physiology
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