Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope

Affinity maturation selects B cells expressing somatically mutated antibody variants with improved antigen-binding properties to protect from invading pathogens. We determined the molecular mechanism underlying the clonal selection and affinity maturation of human B cells expressing protective antib...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-06, Vol.360 (6395), p.1358-1362
Hauptverfasser:	Imkeller, Katharina, Scally, Stephen W, Bosch, Alexandre, Martí, Gemma Pidelaserra, Costa, Giulia, Triller, Gianna, Murugan, Rajagopal, Renna, Valerio, Jumaa, Hassan, Kremsner, Peter G, Sim, B Kim Lee, Hoffman, Stephen L, Mordmüller, Benjamin, Levashina, Elena A, Julien, Jean-Philippe, Wardemann, Hedda
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Antibodies, Protozoan - chemistry Antibodies, Protozoan - genetics Antibodies, Protozoan - immunology Antibody Affinity - genetics Antibody Affinity - immunology Antibody Formation - genetics Antibody Formation - immunology Antigens Antigens, Protozoan - chemistry Antigens, Protozoan - genetics Antigens, Protozoan - immunology B-Lymphocytes - immunology Binding Cell activation Circumsporozoite protein Clonal selection Clustering Epitopes Epitopes, B-Lymphocyte - immunology Erythrocytes Human behavior Humans Immunoglobulins Immunology Lymphocyte Activation Lymphocytes B Malaria Maturation Molecular chains Monoclonal antibodies Mutation Parasites Plasmodium falciparum Plasmodium falciparum - immunology Proteins Protozoan Proteins - genetics Protozoan Proteins - immunology Repetitive Sequences, Nucleic Acid - genetics Repetitive Sequences, Nucleic Acid - immunology Selection, Genetic T cell receptors Vector-borne diseases
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