A chemical–genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase

Reactive oxygen species (ROS) are transient, highly reactive intermediates or byproducts produced during oxygen metabolism. However, when innate mechanisms are unable to cope with sequestration of surplus ROS, oxidative stress results, in which excess ROS damage biomolecules. Oxidized phosphatidylse...

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Veröffentlicht in:	Nature chemical biology 2019-02, Vol.15 (2), p.169-178
Hauptverfasser:	Kelkar, Dhanashree S., Ravikumar, Govindan, Mehendale, Neelay, Singh, Shubham, Joshi, Alaumy, Sharma, Ajay Kumar, Mhetre, Amol, Rajendran, Abinaya, Chakrapani, Harinath, Kamat, Siddhesh S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/287 631/45/607 631/45/608 631/92 Animals Apoptosis Biochemical Engineering Biochemistry Biomolecules Bioorganic Chemistry Cell Biology Cell Line Chemical composition Chemistry Chemistry and Materials Science Chemistry/Food Science Genetic screening Humans Inflammation Intermediates Lipase Lipase - metabolism Lipids Macrophages Macrophages, Peritoneal - metabolism Mammalian cells Mammals Metabolism Mice Monoacylglycerol Lipases - metabolism Monoacylglycerol Lipases - physiology Organic chemistry Oxidation-Reduction Oxidative Stress Oxygen Oxygen metabolism Peritoneum Phosphatidylserine Phosphatidylserines - metabolism Phosphatidylserines - physiology RAW 264.7 Cells Reactive Oxygen Species
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