Progressive increases in fat mass occur in adults living with HIV on antiretroviral therapy, but patterns differ by sex and anatomic depot
Abstract Objectives Although weight gain on ART is common, the long-term trajectory of and factors affecting increases in fat mass in people living with HIV are not well described. Methods Men and women living with HIV in the Modena HIV Metabolic Clinic underwent DXA scans every 6–12 months for up t...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2019-04, Vol.74 (4), p.1028-1034 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | Debroy, Paula Sim, Myung Erlandson, Kristine M Falutz, Julian Prado, Carla M Brown, Todd T Guaraldi, Giovanni Lake, Jordan E |
| description | Abstract
Objectives
Although weight gain on ART is common, the long-term trajectory of and factors affecting increases in fat mass in people living with HIV are not well described.
Methods
Men and women living with HIV in the Modena HIV Metabolic Clinic underwent DXA scans every 6–12 months for up to 10 years (median 4.6 years). Regression modelling in both combined and sex-stratified models determined changes in and clinical factors significantly associated with trunk and leg fat mass over the study period.
Results
A total of 839 women and 1759 men contributed two or more DXA scans. The baseline median age was 44 years and BMI 22.9 kg/m2; 76% were virologically suppressed on ART at baseline. For both sexes, trunk and leg fat consistently increased over the study period, with mean yearly trunk and leg fat gain of 3.6% and 7.5% in women and 6.3% and 10.8% in men, respectively. In multivariate analysis, factors associated with greater fat mass included female sex, per-year ART use (specifically tenofovir disoproxil fumarate and integrase strand transfer inhibitor therapy), per-unit BMI increase, no self-reported physical activity and CD4 nadir |
| doi_str_mv | 10.1093/jac/dky551 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6419613</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/jac/dky551</oup_id><sourcerecordid>2179445020</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-a2a5e45ebad93933ff3740a7e35be049b4485b2bfc9d8106046748a6df4658213</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxi0EokvhwgMgX5AQInQc_0lyQUIV0EqV4ABcLccZ77okcbCdhX0FnhpXWyq4cBjNaOY334z0EfKUwWsGHT-7NvZs-HaQkt0jGyYUVDV07D7ZAAdZNULyE_IopWsAUFK1D8kJB6XahqkN-fUphm3ElPweqZ9tRJMwlYo6k-lkUqLB2jXedMywjjnR0e_9vKU_fN7Ri8uvNJTJnH3EHMPeRzPSvMNolsMr2q-ZLiZnjHOig3cOI-0PNOHPsjKUMDlM3tIBl5AfkwfOjAmf3OZT8uX9u8_nF9XVxw-X52-vKiugzZWpjUQhsTdDxzvOneONANMglz2C6HohWtnXvbPd0DJQIFQjWqMGJ5Rsa8ZPyZuj7rL2Ew4W51ye1kv0k4kHHYzX_05mv9PbsNdKsE4xXgRe3ArE8H3FlPXkk8VxNDOGNemaNZ0QEmoo6MsjamNIKaK7O8NA35ini3n6aF6Bn_392B36x60CPD8CYV3-J_QbcBumCg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2179445020</pqid></control><display><type>article</type><title>Progressive increases in fat mass occur in adults living with HIV on antiretroviral therapy, but patterns differ by sex and anatomic depot</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Debroy, Paula ; Sim, Myung ; Erlandson, Kristine M ; Falutz, Julian ; Prado, Carla M ; Brown, Todd T ; Guaraldi, Giovanni ; Lake, Jordan E</creator><creatorcontrib>Debroy, Paula ; Sim, Myung ; Erlandson, Kristine M ; Falutz, Julian ; Prado, Carla M ; Brown, Todd T ; Guaraldi, Giovanni ; Lake, Jordan E</creatorcontrib><description>Abstract
Objectives
Although weight gain on ART is common, the long-term trajectory of and factors affecting increases in fat mass in people living with HIV are not well described.
Methods
Men and women living with HIV in the Modena HIV Metabolic Clinic underwent DXA scans every 6–12 months for up to 10 years (median 4.6 years). Regression modelling in both combined and sex-stratified models determined changes in and clinical factors significantly associated with trunk and leg fat mass over the study period.
Results
A total of 839 women and 1759 men contributed two or more DXA scans. The baseline median age was 44 years and BMI 22.9 kg/m2; 76% were virologically suppressed on ART at baseline. For both sexes, trunk and leg fat consistently increased over the study period, with mean yearly trunk and leg fat gain of 3.6% and 7.5% in women and 6.3% and 10.8% in men, respectively. In multivariate analysis, factors associated with greater fat mass included female sex, per-year ART use (specifically tenofovir disoproxil fumarate and integrase strand transfer inhibitor therapy), per-unit BMI increase, no self-reported physical activity and CD4 nadir <200 cells/mm3.
Conclusions
Among people living with HIV on ART, trunk and leg fat mass increased steadily over a median of 4.6 years of follow up, particularly among women. After controlling for traditional risk factors, HIV- and ART-specific risk factors emerged.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dky551</identifier><identifier>PMID: 30668716</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Absorptiometry, Photon ; Adipose Tissue - anatomy & histology ; Adipose Tissue - diagnostic imaging ; Adipose Tissue - pathology ; Adiposity ; Adult ; Anti-HIV Agents - therapeutic use ; Antiretroviral Therapy, Highly Active ; CD4 Lymphocyte Count ; Comorbidity ; Female ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; HIV Infections - virology ; Humans ; Male ; Middle Aged ; Organ Size ; Original Research ; Young Adult</subject><ispartof>Journal of antimicrobial chemotherapy, 2019-04, Vol.74 (4), p.1028-1034</ispartof><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com. 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-a2a5e45ebad93933ff3740a7e35be049b4485b2bfc9d8106046748a6df4658213</citedby><cites>FETCH-LOGICAL-c408t-a2a5e45ebad93933ff3740a7e35be049b4485b2bfc9d8106046748a6df4658213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30668716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Debroy, Paula</creatorcontrib><creatorcontrib>Sim, Myung</creatorcontrib><creatorcontrib>Erlandson, Kristine M</creatorcontrib><creatorcontrib>Falutz, Julian</creatorcontrib><creatorcontrib>Prado, Carla M</creatorcontrib><creatorcontrib>Brown, Todd T</creatorcontrib><creatorcontrib>Guaraldi, Giovanni</creatorcontrib><creatorcontrib>Lake, Jordan E</creatorcontrib><title>Progressive increases in fat mass occur in adults living with HIV on antiretroviral therapy, but patterns differ by sex and anatomic depot</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Abstract
Objectives
Although weight gain on ART is common, the long-term trajectory of and factors affecting increases in fat mass in people living with HIV are not well described.
Methods
Men and women living with HIV in the Modena HIV Metabolic Clinic underwent DXA scans every 6–12 months for up to 10 years (median 4.6 years). Regression modelling in both combined and sex-stratified models determined changes in and clinical factors significantly associated with trunk and leg fat mass over the study period.
Results
A total of 839 women and 1759 men contributed two or more DXA scans. The baseline median age was 44 years and BMI 22.9 kg/m2; 76% were virologically suppressed on ART at baseline. For both sexes, trunk and leg fat consistently increased over the study period, with mean yearly trunk and leg fat gain of 3.6% and 7.5% in women and 6.3% and 10.8% in men, respectively. In multivariate analysis, factors associated with greater fat mass included female sex, per-year ART use (specifically tenofovir disoproxil fumarate and integrase strand transfer inhibitor therapy), per-unit BMI increase, no self-reported physical activity and CD4 nadir <200 cells/mm3.
Conclusions
Among people living with HIV on ART, trunk and leg fat mass increased steadily over a median of 4.6 years of follow up, particularly among women. After controlling for traditional risk factors, HIV- and ART-specific risk factors emerged.</description><subject>Absorptiometry, Photon</subject><subject>Adipose Tissue - anatomy & histology</subject><subject>Adipose Tissue - diagnostic imaging</subject><subject>Adipose Tissue - pathology</subject><subject>Adiposity</subject><subject>Adult</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>CD4 Lymphocyte Count</subject><subject>Comorbidity</subject><subject>Female</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - virology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Organ Size</subject><subject>Original Research</subject><subject>Young Adult</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxi0EokvhwgMgX5AQInQc_0lyQUIV0EqV4ABcLccZ77okcbCdhX0FnhpXWyq4cBjNaOY334z0EfKUwWsGHT-7NvZs-HaQkt0jGyYUVDV07D7ZAAdZNULyE_IopWsAUFK1D8kJB6XahqkN-fUphm3ElPweqZ9tRJMwlYo6k-lkUqLB2jXedMywjjnR0e_9vKU_fN7Ri8uvNJTJnH3EHMPeRzPSvMNolsMr2q-ZLiZnjHOig3cOI-0PNOHPsjKUMDlM3tIBl5AfkwfOjAmf3OZT8uX9u8_nF9XVxw-X52-vKiugzZWpjUQhsTdDxzvOneONANMglz2C6HohWtnXvbPd0DJQIFQjWqMGJ5Rsa8ZPyZuj7rL2Ew4W51ye1kv0k4kHHYzX_05mv9PbsNdKsE4xXgRe3ArE8H3FlPXkk8VxNDOGNemaNZ0QEmoo6MsjamNIKaK7O8NA35ini3n6aF6Bn_392B36x60CPD8CYV3-J_QbcBumCg</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Debroy, Paula</creator><creator>Sim, Myung</creator><creator>Erlandson, Kristine M</creator><creator>Falutz, Julian</creator><creator>Prado, Carla M</creator><creator>Brown, Todd T</creator><creator>Guaraldi, Giovanni</creator><creator>Lake, Jordan E</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190401</creationdate><title>Progressive increases in fat mass occur in adults living with HIV on antiretroviral therapy, but patterns differ by sex and anatomic depot</title><author>Debroy, Paula ; Sim, Myung ; Erlandson, Kristine M ; Falutz, Julian ; Prado, Carla M ; Brown, Todd T ; Guaraldi, Giovanni ; Lake, Jordan E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-a2a5e45ebad93933ff3740a7e35be049b4485b2bfc9d8106046748a6df4658213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Absorptiometry, Photon</topic><topic>Adipose Tissue - anatomy & histology</topic><topic>Adipose Tissue - diagnostic imaging</topic><topic>Adipose Tissue - pathology</topic><topic>Adiposity</topic><topic>Adult</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>CD4 Lymphocyte Count</topic><topic>Comorbidity</topic><topic>Female</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - virology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Organ Size</topic><topic>Original Research</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Debroy, Paula</creatorcontrib><creatorcontrib>Sim, Myung</creatorcontrib><creatorcontrib>Erlandson, Kristine M</creatorcontrib><creatorcontrib>Falutz, Julian</creatorcontrib><creatorcontrib>Prado, Carla M</creatorcontrib><creatorcontrib>Brown, Todd T</creatorcontrib><creatorcontrib>Guaraldi, Giovanni</creatorcontrib><creatorcontrib>Lake, Jordan E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Debroy, Paula</au><au>Sim, Myung</au><au>Erlandson, Kristine M</au><au>Falutz, Julian</au><au>Prado, Carla M</au><au>Brown, Todd T</au><au>Guaraldi, Giovanni</au><au>Lake, Jordan E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progressive increases in fat mass occur in adults living with HIV on antiretroviral therapy, but patterns differ by sex and anatomic depot</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>74</volume><issue>4</issue><spage>1028</spage><epage>1034</epage><pages>1028-1034</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><abstract>Abstract
Objectives
Although weight gain on ART is common, the long-term trajectory of and factors affecting increases in fat mass in people living with HIV are not well described.
Methods
Men and women living with HIV in the Modena HIV Metabolic Clinic underwent DXA scans every 6–12 months for up to 10 years (median 4.6 years). Regression modelling in both combined and sex-stratified models determined changes in and clinical factors significantly associated with trunk and leg fat mass over the study period.
Results
A total of 839 women and 1759 men contributed two or more DXA scans. The baseline median age was 44 years and BMI 22.9 kg/m2; 76% were virologically suppressed on ART at baseline. For both sexes, trunk and leg fat consistently increased over the study period, with mean yearly trunk and leg fat gain of 3.6% and 7.5% in women and 6.3% and 10.8% in men, respectively. In multivariate analysis, factors associated with greater fat mass included female sex, per-year ART use (specifically tenofovir disoproxil fumarate and integrase strand transfer inhibitor therapy), per-unit BMI increase, no self-reported physical activity and CD4 nadir <200 cells/mm3.
Conclusions
Among people living with HIV on ART, trunk and leg fat mass increased steadily over a median of 4.6 years of follow up, particularly among women. After controlling for traditional risk factors, HIV- and ART-specific risk factors emerged.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>30668716</pmid><doi>10.1093/jac/dky551</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Absorptiometry, Photon Adipose Tissue - anatomy & histology Adipose Tissue - diagnostic imaging Adipose Tissue - pathology Adiposity Adult Anti-HIV Agents - therapeutic use Antiretroviral Therapy, Highly Active CD4 Lymphocyte Count Comorbidity Female HIV Infections - drug therapy HIV Infections - epidemiology HIV Infections - virology Humans Male Middle Aged Organ Size Original Research Young Adult |
| title | Progressive increases in fat mass occur in adults living with HIV on antiretroviral therapy, but patterns differ by sex and anatomic depot |
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