Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery
The temperature responsive PEGylated polyaspartamide derivative, denoted as mPEG-PAAHP, was synthesized by the click reaction. FTIR and ¹H NMR were adopted to characterize and confirm the chemical structures of the obtained mPEG-PAAHPs. The temperature responsive behavior investigated by transmittan...
Gespeichert in:
Veröffentlicht in: | Polymers 2019-02, Vol.11 (2), p.316 |
---|---|
Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | 2 |
container_start_page | 316 |
container_title | Polymers |
container_volume | 11 |
creator | Zhang, Guangyan Jiang, Xulin |
description | The temperature responsive PEGylated polyaspartamide derivative, denoted as mPEG-PAAHP, was synthesized by the click reaction. FTIR and ¹H NMR were adopted to characterize and confirm the chemical structures of the obtained mPEG-PAAHPs. The temperature responsive behavior investigated by transmittance and dynamic light scattering showed that some of the obtained mPEG-PAAHPs exhibited obvious temperature responsiveness and could be used to prepare nanoparticles by quickly heating. Drug paclitaxel can be encapsulated into mPEG-PAAHP based nanoparticles with a high encapsulation efficiency up to 99% (corresponding to a drug loading content of around 9.9%). Dynamic light scattering results showed that the PTX-loaded nanoparticles had a mean size around 80 nm (PDI |
doi_str_mv | 10.3390/polym11020316 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6419189</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2557235235</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-ee6d8b5004e21d53841918aa8d4f4863041db83c5d401fc8f0a123db527a09ec3</originalsourceid><addsrcrecordid>eNpdkd9LwzAQx4MoTuYefZWCL75U86PJ2hdBN52CqMh8DrfmOittU5N2sP_eTKeoIZDk8rnv944j5IjRMyEyet7aal0zRjkVTO2QA07HIk6Eoru_7gMy8v6NhpVIpdh4nwwEzRTlWXZAcI51iw663mH0jL61jS9XGD1AY1twXZlX6KMr8Ggi20RP17N1BV14PAVr8BsE6tJgNEVXrqALuT4qrIumrl-GYBUCbn1I9gqoPI6255C83FzPJ7fx_ePsbnJ5H-cJk12MqEy6kKFQ5MxIkSYsYylAapIiSZWgCTOLVOTSJJQVeVpQYFyYheRjoBnmYkguvnTbflGjybHpHFS6dWUNbq0tlPrvT1O-6qVdafXplAWB062As-89-k7Xpc-xqqBB23vNOVWcSxZsh-TkH_pme9eE9jSXcsyFDDtQ8ReVO-u9w-KnGEb1Zob6zwwDf_y7gx_6e2LiA7ObmZA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2557235235</pqid></control><display><type>article</type><title>Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><source>PubMed Central Open Access</source><creator>Zhang, Guangyan ; Jiang, Xulin</creator><creatorcontrib>Zhang, Guangyan ; Jiang, Xulin</creatorcontrib><description>The temperature responsive PEGylated polyaspartamide derivative, denoted as mPEG-PAAHP, was synthesized by the click reaction. FTIR and ¹H NMR were adopted to characterize and confirm the chemical structures of the obtained mPEG-PAAHPs. The temperature responsive behavior investigated by transmittance and dynamic light scattering showed that some of the obtained mPEG-PAAHPs exhibited obvious temperature responsiveness and could be used to prepare nanoparticles by quickly heating. Drug paclitaxel can be encapsulated into mPEG-PAAHP based nanoparticles with a high encapsulation efficiency up to 99% (corresponding to a drug loading content of around 9.9%). Dynamic light scattering results showed that the PTX-loaded nanoparticles had a mean size around 80 nm (PDI<0.2) and good stability in PBS with 150 mM ionic strength. In vitro cytotoxicity results showed that mPEG-PAAHP did not show any toxicity to HeLa cells, but the PTX-loaded nanoparticles based on mPEG-PAAHP exhibited obvious anti-cancer activity. Thus, the temperature responsive PEGylated polyaspartamide derivative mPEG-PAAHP may be a promising drug delivery system.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym11020316</identifier><identifier>PMID: 30960299</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alcohol ; Anticancer properties ; Aqueous solutions ; Chemical reactions ; Chromatography ; Drug delivery systems ; Efficiency ; Encapsulation ; Hemodialysis ; MPEG encoders ; Nanoparticles ; NMR ; Nuclear magnetic resonance ; Photon correlation spectroscopy ; Polyethylene glycol ; Polymers ; Scattering ; Toxicity</subject><ispartof>Polymers, 2019-02, Vol.11 (2), p.316</ispartof><rights>2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-ee6d8b5004e21d53841918aa8d4f4863041db83c5d401fc8f0a123db527a09ec3</citedby><cites>FETCH-LOGICAL-c415t-ee6d8b5004e21d53841918aa8d4f4863041db83c5d401fc8f0a123db527a09ec3</cites><orcidid>0000-0003-1513-0003</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419189/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419189/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30960299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Guangyan</creatorcontrib><creatorcontrib>Jiang, Xulin</creatorcontrib><title>Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery</title><title>Polymers</title><addtitle>Polymers (Basel)</addtitle><description>The temperature responsive PEGylated polyaspartamide derivative, denoted as mPEG-PAAHP, was synthesized by the click reaction. FTIR and ¹H NMR were adopted to characterize and confirm the chemical structures of the obtained mPEG-PAAHPs. The temperature responsive behavior investigated by transmittance and dynamic light scattering showed that some of the obtained mPEG-PAAHPs exhibited obvious temperature responsiveness and could be used to prepare nanoparticles by quickly heating. Drug paclitaxel can be encapsulated into mPEG-PAAHP based nanoparticles with a high encapsulation efficiency up to 99% (corresponding to a drug loading content of around 9.9%). Dynamic light scattering results showed that the PTX-loaded nanoparticles had a mean size around 80 nm (PDI<0.2) and good stability in PBS with 150 mM ionic strength. In vitro cytotoxicity results showed that mPEG-PAAHP did not show any toxicity to HeLa cells, but the PTX-loaded nanoparticles based on mPEG-PAAHP exhibited obvious anti-cancer activity. Thus, the temperature responsive PEGylated polyaspartamide derivative mPEG-PAAHP may be a promising drug delivery system.</description><subject>Alcohol</subject><subject>Anticancer properties</subject><subject>Aqueous solutions</subject><subject>Chemical reactions</subject><subject>Chromatography</subject><subject>Drug delivery systems</subject><subject>Efficiency</subject><subject>Encapsulation</subject><subject>Hemodialysis</subject><subject>MPEG encoders</subject><subject>Nanoparticles</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Photon correlation spectroscopy</subject><subject>Polyethylene glycol</subject><subject>Polymers</subject><subject>Scattering</subject><subject>Toxicity</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkd9LwzAQx4MoTuYefZWCL75U86PJ2hdBN52CqMh8DrfmOittU5N2sP_eTKeoIZDk8rnv944j5IjRMyEyet7aal0zRjkVTO2QA07HIk6Eoru_7gMy8v6NhpVIpdh4nwwEzRTlWXZAcI51iw663mH0jL61jS9XGD1AY1twXZlX6KMr8Ggi20RP17N1BV14PAVr8BsE6tJgNEVXrqALuT4qrIumrl-GYBUCbn1I9gqoPI6255C83FzPJ7fx_ePsbnJ5H-cJk12MqEy6kKFQ5MxIkSYsYylAapIiSZWgCTOLVOTSJJQVeVpQYFyYheRjoBnmYkguvnTbflGjybHpHFS6dWUNbq0tlPrvT1O-6qVdafXplAWB062As-89-k7Xpc-xqqBB23vNOVWcSxZsh-TkH_pme9eE9jSXcsyFDDtQ8ReVO-u9w-KnGEb1Zob6zwwDf_y7gx_6e2LiA7ObmZA</recordid><startdate>20190213</startdate><enddate>20190213</enddate><creator>Zhang, Guangyan</creator><creator>Jiang, Xulin</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1513-0003</orcidid></search><sort><creationdate>20190213</creationdate><title>Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery</title><author>Zhang, Guangyan ; Jiang, Xulin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-ee6d8b5004e21d53841918aa8d4f4863041db83c5d401fc8f0a123db527a09ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alcohol</topic><topic>Anticancer properties</topic><topic>Aqueous solutions</topic><topic>Chemical reactions</topic><topic>Chromatography</topic><topic>Drug delivery systems</topic><topic>Efficiency</topic><topic>Encapsulation</topic><topic>Hemodialysis</topic><topic>MPEG encoders</topic><topic>Nanoparticles</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Photon correlation spectroscopy</topic><topic>Polyethylene glycol</topic><topic>Polymers</topic><topic>Scattering</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Guangyan</creatorcontrib><creatorcontrib>Jiang, Xulin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Guangyan</au><au>Jiang, Xulin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery</atitle><jtitle>Polymers</jtitle><addtitle>Polymers (Basel)</addtitle><date>2019-02-13</date><risdate>2019</risdate><volume>11</volume><issue>2</issue><spage>316</spage><pages>316-</pages><issn>2073-4360</issn><eissn>2073-4360</eissn><abstract>The temperature responsive PEGylated polyaspartamide derivative, denoted as mPEG-PAAHP, was synthesized by the click reaction. FTIR and ¹H NMR were adopted to characterize and confirm the chemical structures of the obtained mPEG-PAAHPs. The temperature responsive behavior investigated by transmittance and dynamic light scattering showed that some of the obtained mPEG-PAAHPs exhibited obvious temperature responsiveness and could be used to prepare nanoparticles by quickly heating. Drug paclitaxel can be encapsulated into mPEG-PAAHP based nanoparticles with a high encapsulation efficiency up to 99% (corresponding to a drug loading content of around 9.9%). Dynamic light scattering results showed that the PTX-loaded nanoparticles had a mean size around 80 nm (PDI<0.2) and good stability in PBS with 150 mM ionic strength. In vitro cytotoxicity results showed that mPEG-PAAHP did not show any toxicity to HeLa cells, but the PTX-loaded nanoparticles based on mPEG-PAAHP exhibited obvious anti-cancer activity. Thus, the temperature responsive PEGylated polyaspartamide derivative mPEG-PAAHP may be a promising drug delivery system.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30960299</pmid><doi>10.3390/polym11020316</doi><orcidid>https://orcid.org/0000-0003-1513-0003</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2073-4360 |
ispartof | Polymers, 2019-02, Vol.11 (2), p.316 |
issn | 2073-4360 2073-4360 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6419189 |
source | MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
subjects | Alcohol Anticancer properties Aqueous solutions Chemical reactions Chromatography Drug delivery systems Efficiency Encapsulation Hemodialysis MPEG encoders Nanoparticles NMR Nuclear magnetic resonance Photon correlation spectroscopy Polyethylene glycol Polymers Scattering Toxicity |
title | Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T17%3A55%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Temperature%20Responsive%20Nanoparticles%20Based%20on%20PEGylated%20Polyaspartamide%20Derivatives%20for%20Drug%20Delivery&rft.jtitle=Polymers&rft.au=Zhang,%20Guangyan&rft.date=2019-02-13&rft.volume=11&rft.issue=2&rft.spage=316&rft.pages=316-&rft.issn=2073-4360&rft.eissn=2073-4360&rft_id=info:doi/10.3390/polym11020316&rft_dat=%3Cproquest_pubme%3E2557235235%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2557235235&rft_id=info:pmid/30960299&rfr_iscdi=true |