Inhibition of non‐receptor tyrosine kinase Src induces phosphoserine 256‐independent aquaporin‐2 membrane accumulation

Key points Aquaporin‐2 (AQP2) is crucial for water homeostasis, and vasopressin (VP) induces AQP2 membrane trafficking by increasing intracellular cAMP, activating PKA and causing phosphorylation of AQP2 at serine 256, 264 and 269 residues and dephosphorylation of serine 261 residue on the AQP2 C‐te...

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Veröffentlicht in:	The Journal of physiology 2019-03, Vol.597 (6), p.1627-1642
Hauptverfasser:	Cheung, Pui W., Terlouw, Abby, Janssen, Sam Antoon, Brown, Dennis, Bouley, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aquaporin 2 Aquaporin 2 - genetics Aquaporin 2 - metabolism Aquaporins Cell Line Clathrin Collecting duct Dasatinib - pharmacology Endocytosis Exocytosis Homeostasis Male Membrane trafficking Mutation, Missense non‐receptor kinase Phosphorylation Phosphoserine Protein kinase A Protein Kinase Inhibitors - pharmacology Protein-tyrosine kinase receptors Rats Rats, Sprague-Dawley Renal Research Paper Serine Signal Transduction siRNA src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism Swine trafficking Vasopressin Vasopressins - metabolism water channel
Online-Zugang:	Volltext
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