Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations

Humans are repeatedly exposed to influenza virus via infections and vaccinations. Understanding how multiple exposures and pre-existing immunity impact antibody responses is essential for vaccine development. Given the recent prevalence of influenza H1N1 A/California/7/2009 (CA09), we examined the c...

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Veröffentlicht in:	Cell host & microbe 2019-03, Vol.25 (3), p.367-376.e5
Hauptverfasser:	Lee, Jiwon, Paparoditis, Philipp, Horton, Andrew P., Frühwirth, Alexander, McDaniel, Jonathan R., Jung, Jiwon, Boutz, Daniel R., Hussein, Dania A., Tanno, Yuri, Pappas, Leontios, Ippolito, Gregory C., Corti, Davide, Lanzavecchia, Antonio, Georgiou, George
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-hemagglutinin antibodies Antibodies, Viral - blood Female Hemagglutinin Glycoproteins, Influenza Virus - immunology Humans humoral immunity Immunity, Humoral Immunoglobulin G - blood immunological imprinting influenza vaccine response Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - immunology Influenza, Human - prevention & control longitudinal profiling Middle Aged Orthomyxoviridae - immunology persistent antibodies Serum - immunology serum antibody repertoire Switzerland
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