Biosensor-based epitope mapping of antibodies targeting the hemagglutinin and neuraminidase of influenza A virus

Characterization of the epitopes on antigen recognized by monoclonal antibodies (mAb) is useful for the development of therapeutic antibodies, diagnostic tools, and vaccines. Epitope mapping also provides functional information for sequence-based repertoire analysis of antibody response to pathogen...

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Veröffentlicht in:	Journal of immunological methods 2018-10, Vol.461, p.23-29
Hauptverfasser:	Guo, Zhu, Wilson, Jason R., York, Ian A., Stevens, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - chemistry Antibodies, Viral - chemistry Biosensing Techniques - methods biosensors diagnostic techniques epitope mapping Epitope Mapping - methods epitopes Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology hemagglutinins Humans Influenza A virus Influenza A virus - genetics Influenza A virus - immunology interferometry Interferometry - methods monoclonal antibodies mutants Neuraminidase - genetics Neuraminidase - immunology pathogens Point Mutation sialidase site-directed mutagenesis vaccination vaccines
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