Crystal structures of thiamine monophosphate kinase from Acinetobacter baumannii in complex with substrates and products

Thiamine monophosphate kinase (ThiL) catalyzes the last step of thiamine pyrophosphate (TPP) synthesis, the ATP-dependent phosphorylation of thiamine monophosphate (TMP) to thiamine pyrophosphate. We solved the structure of ThiL from the human pathogen A. baumanii in complex with a pair of substrate...

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Veröffentlicht in:	Scientific reports 2019-03, Vol.9 (1), p.4392-4392, Article 4392
Hauptverfasser:	Sullivan, Amy H., Dranow, David M., Horanyi, Peter S., Lorimer, Donald D., Edwards, Thomas E., Abendroth, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/535/1266 631/535/1266 Acinetobacter baumannii - enzymology Acinetobacter baumannii - metabolism Adenosine Adenosine diphosphate Adenosine Diphosphate - metabolism Adenosine triphosphate Adenosine Triphosphate - metabolism ATP BASIC BIOLOGICAL SCIENCES Catalytic Domain Crystallization Humanities and Social Sciences multidisciplinary Phosphorylation Phosphotransferases (Phosphate Group Acceptor) - metabolism Science Science (multidisciplinary) Thiamine Thiamine Pyrophosphate - metabolism Vitamin B X-ray crystallography
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