Different somatostatin and CXCR4 chemokine receptor expression in gastroenteropancreatic neuroendocrine neoplasms depending on their origin

Somatostatin receptors (SST), especially SST2A, are known for their overexpression in well-differentiated gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). The chemokine receptor CXCR4, in contrast, is considered to be present mainly in highly proliferative and advanced tumors. However, com...

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Veröffentlicht in:	Scientific reports 2019-03, Vol.9 (1), p.4339, Article 4339
Hauptverfasser:	Mai, Rebekka, Kaemmerer, Daniel, Träger, Tina, Neubauer, Elisa, Sänger, Jörg, Baum, Richard P., Schulz, Stefan, Lupp, Amelie
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/51 631/67/1459 692/4028/67/1504 Adolescent Adult Aged Aged, 80 and over Chemokines Child Clinical outcomes Colon CXCR4 protein Female Gastrointestinal Neoplasms - metabolism Gastrointestinal Neoplasms - pathology Gastrointestinal tract Humanities and Social Sciences Humans Immunohistochemistry Male Metastases Middle Aged Monoclonal antibodies multidisciplinary Neuroendocrine tumors Neuroendocrine Tumors - metabolism Neuroendocrine Tumors - pathology Pancreas Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Receptors, CXCR4 - metabolism Receptors, Somatostatin - metabolism Science Science (multidisciplinary) Somatostatin Somatostatin receptors Tumors Young Adult
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