Genetic identification of a population of noradrenergic neurons implicated in attenuation of stress-related responses

Noradrenergic signaling plays a well-established role in promoting the stress response. Here we identify a subpopulation of noradrenergic neurons, defined by developmental expression of Hoxb1 , that has a unique role in modulating stress-related behavior. Using an intersectional chemogenetic strateg...

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Veröffentlicht in:	Molecular psychiatry 2019-05, Vol.24 (5), p.710-725
Hauptverfasser:	Chen, Yu-Wei, Das, Manasmita, Oyarzabal, Esteban A., Cheng, Qing, Plummer, Nicholas W., Smith, Kathleen G., Jones, Grace K., Malawsky, Daniel, Yakel, Jerrel L., Shih, Yen-Yu Ian, Jensen, Patricia
Format:	Artikel
Sprache:	eng
Schlagworte:	13/44 13/51 14/19 14/32 59/36 631/208 631/378 64/60 9/74 Adaptation, Psychological - physiology Adrenergic Neurons - metabolism Adrenergic Neurons - physiology Amygdala Amygdala - metabolism Animal genetic engineering Animals Anxiety Anxiety - genetics Anxiety - metabolism Behavior, Animal - physiology Behavioral Sciences Biological Psychology Blood volume Brain Brain - metabolism Brain mapping Cerebral blood flow Diagnostic imaging Female Functional magnetic resonance imaging Genetic aspects Homeodomain Proteins - genetics Homeodomain Proteins - metabolism HOXB1 protein Identification and classification Locus coeruleus Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Transgenic Neuroimaging Neurons Neurons - metabolism Neurophysiology Neurosciences Norepinephrine Pharmacotherapy Physiological aspects Population genetics Psychiatry Psychological aspects Stress Stress (Psychology) Stress response Stress, Physiological - genetics Stria terminalis Subpopulations
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