New insights into arterial stiffening: does sex matter?
This review discusses sexual dimorphism in arterial stiffening, disease pathology interactions, and the influence of sex on mechanisms and pathways. Arterial stiffness predicts cardiovascular mortality independent of blood pressure. Patients with increased arterial stiffness have a 48% higher risk f...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2018-11, Vol.315 (5), p.H1073-H1087 |
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| container_issue | 5 |
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| container_title | American journal of physiology. Heart and circulatory physiology |
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| creator | Ogola, Benard O Zimmerman, Margaret A Clark, Gabrielle L Abshire, Caleb M Gentry, Kaylee M Miller, Kristin S Lindsey, Sarah H |
| description | This review discusses sexual dimorphism in arterial stiffening, disease pathology interactions, and the influence of sex on mechanisms and pathways. Arterial stiffness predicts cardiovascular mortality independent of blood pressure. Patients with increased arterial stiffness have a 48% higher risk for developing cardiovascular disease. Like other cardiovascular pathologies, arterial stiffness is sexually dimorphic. Young women have lower stiffness than aged-matched men, but this sex difference reverses during normal aging. Estrogen therapy does not attenuate progressive stiffening in postmenopausal women, indicating that currently prescribed drugs do not confer protection. Although remodeling of large arteries is a protective adaptation to higher wall stress, arterial stiffening increases afterload to the left ventricle and transmits higher pulsatile pressure to smaller arteries and target organs. Moreover, an increase in aortic stiffness may precede or exacerbate hypertension, particularly during aging. Additional studies are needed to elucidate the mechanisms by which females are protected from arterial stiffness to provide insight into its mechanisms and, ultimately, therapeutic targets for treating this pathology. |
| doi_str_mv | 10.1152/ajpheart.00132.2018 |
| format | Article |
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Arterial stiffness predicts cardiovascular mortality independent of blood pressure. Patients with increased arterial stiffness have a 48% higher risk for developing cardiovascular disease. Like other cardiovascular pathologies, arterial stiffness is sexually dimorphic. Young women have lower stiffness than aged-matched men, but this sex difference reverses during normal aging. Estrogen therapy does not attenuate progressive stiffening in postmenopausal women, indicating that currently prescribed drugs do not confer protection. Although remodeling of large arteries is a protective adaptation to higher wall stress, arterial stiffening increases afterload to the left ventricle and transmits higher pulsatile pressure to smaller arteries and target organs. Moreover, an increase in aortic stiffness may precede or exacerbate hypertension, particularly during aging. Additional studies are needed to elucidate the mechanisms by which females are protected from arterial stiffness to provide insight into its mechanisms and, ultimately, therapeutic targets for treating this pathology.</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.00132.2018</identifier><identifier>PMID: 30028199</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Age Factors ; Aging ; Animals ; Aorta ; Arterial Pressure ; Arteries ; Arteries - drug effects ; Arteries - metabolism ; Arteries - physiopathology ; Blood pressure ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - physiopathology ; Cardiovascular Diseases - prevention & control ; Cardiovascular system ; Disease Models, Animal ; Drug development ; Estrogen Replacement Therapy ; Estrogens ; Estrogens - blood ; Female ; Females ; Health risks ; Health Status Disparities ; Humans ; Hypertension ; Male ; Menopause ; Organs ; Pathology ; Post-menopause ; Protective Factors ; Review ; Risk Factors ; Sex ; Sex Characteristics ; Sex Factors ; Sexual dimorphism ; Stiffening ; Stiffness ; Testosterone - blood ; Therapeutic applications ; Vascular Stiffness ; Ventricle</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2018-11, Vol.315 (5), p.H1073-H1087</ispartof><rights>Copyright American Physiological Society Nov 2018</rights><rights>Copyright © 2018 the American Physiological Society 2018 American Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-15ce5c92fbea435d87563efbe2e5d654136f5fa991c5e8c84ce41c9b42b7f22b3</citedby><cites>FETCH-LOGICAL-c363t-15ce5c92fbea435d87563efbe2e5d654136f5fa991c5e8c84ce41c9b42b7f22b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,3040,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30028199$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogola, Benard O</creatorcontrib><creatorcontrib>Zimmerman, Margaret A</creatorcontrib><creatorcontrib>Clark, Gabrielle L</creatorcontrib><creatorcontrib>Abshire, Caleb M</creatorcontrib><creatorcontrib>Gentry, Kaylee M</creatorcontrib><creatorcontrib>Miller, Kristin S</creatorcontrib><creatorcontrib>Lindsey, Sarah H</creatorcontrib><title>New insights into arterial stiffening: does sex matter?</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description>This review discusses sexual dimorphism in arterial stiffening, disease pathology interactions, and the influence of sex on mechanisms and pathways. Arterial stiffness predicts cardiovascular mortality independent of blood pressure. Patients with increased arterial stiffness have a 48% higher risk for developing cardiovascular disease. Like other cardiovascular pathologies, arterial stiffness is sexually dimorphic. Young women have lower stiffness than aged-matched men, but this sex difference reverses during normal aging. Estrogen therapy does not attenuate progressive stiffening in postmenopausal women, indicating that currently prescribed drugs do not confer protection. Although remodeling of large arteries is a protective adaptation to higher wall stress, arterial stiffening increases afterload to the left ventricle and transmits higher pulsatile pressure to smaller arteries and target organs. Moreover, an increase in aortic stiffness may precede or exacerbate hypertension, particularly during aging. Additional studies are needed to elucidate the mechanisms by which females are protected from arterial stiffness to provide insight into its mechanisms and, ultimately, therapeutic targets for treating this pathology.</description><subject>Age Factors</subject><subject>Aging</subject><subject>Animals</subject><subject>Aorta</subject><subject>Arterial Pressure</subject><subject>Arteries</subject><subject>Arteries - drug effects</subject><subject>Arteries - metabolism</subject><subject>Arteries - physiopathology</subject><subject>Blood pressure</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Cardiovascular system</subject><subject>Disease Models, Animal</subject><subject>Drug development</subject><subject>Estrogen Replacement Therapy</subject><subject>Estrogens</subject><subject>Estrogens - blood</subject><subject>Female</subject><subject>Females</subject><subject>Health risks</subject><subject>Health Status Disparities</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Menopause</subject><subject>Organs</subject><subject>Pathology</subject><subject>Post-menopause</subject><subject>Protective Factors</subject><subject>Review</subject><subject>Risk Factors</subject><subject>Sex</subject><subject>Sex Characteristics</subject><subject>Sex Factors</subject><subject>Sexual dimorphism</subject><subject>Stiffening</subject><subject>Stiffness</subject><subject>Testosterone - blood</subject><subject>Therapeutic applications</subject><subject>Vascular Stiffness</subject><subject>Ventricle</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUlPwzAQhS0EoqXwC5BQJC5cUrwmMQcQqtikCi5wthxn0rrKUuyE5d_j0hYBJ9t6b97M-EPomOAxIYKe68VyDtp1Y4wJo2OKSbaDhkGhMRFM7qIhZgmLE8LEAB14v8AYizRh-2jAMKYZkXKI0kd4j2zj7Wze-XDp2ihEgrO6inxnyxIa28wuoqIFH3n4iGrdBfnqEO2VuvJwtDlH6OX25nlyH0-f7h4m19PYhN5dGMSAMJKWOWjORJGlImEQXhREkQhOWFKKUktJjIDMZNwAJ0bmnOZpSWnORuhynbvs8xoKA03ndKWWztbafapWW_VXaexczdo3lXAiUk5DwNkmwLWvPfhO1dYbqCrdQNt7RXHKGMk4IcF6-s-6aHvXhPUUDT-cZFJiHlxs7TKu9d5B-TMMwWoFRm3BqG8wagUmVJ383uOnZkuCfQHu3YvY</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Ogola, Benard O</creator><creator>Zimmerman, Margaret A</creator><creator>Clark, Gabrielle L</creator><creator>Abshire, Caleb M</creator><creator>Gentry, Kaylee M</creator><creator>Miller, Kristin S</creator><creator>Lindsey, Sarah H</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181101</creationdate><title>New insights into arterial stiffening: does sex matter?</title><author>Ogola, Benard O ; Zimmerman, Margaret A ; Clark, Gabrielle L ; Abshire, Caleb M ; Gentry, Kaylee M ; Miller, Kristin S ; Lindsey, Sarah H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-15ce5c92fbea435d87563efbe2e5d654136f5fa991c5e8c84ce41c9b42b7f22b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age Factors</topic><topic>Aging</topic><topic>Animals</topic><topic>Aorta</topic><topic>Arterial Pressure</topic><topic>Arteries</topic><topic>Arteries - drug effects</topic><topic>Arteries - metabolism</topic><topic>Arteries - physiopathology</topic><topic>Blood pressure</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Cardiovascular system</topic><topic>Disease Models, Animal</topic><topic>Drug development</topic><topic>Estrogen Replacement Therapy</topic><topic>Estrogens</topic><topic>Estrogens - blood</topic><topic>Female</topic><topic>Females</topic><topic>Health risks</topic><topic>Health Status Disparities</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Male</topic><topic>Menopause</topic><topic>Organs</topic><topic>Pathology</topic><topic>Post-menopause</topic><topic>Protective Factors</topic><topic>Review</topic><topic>Risk Factors</topic><topic>Sex</topic><topic>Sex Characteristics</topic><topic>Sex Factors</topic><topic>Sexual dimorphism</topic><topic>Stiffening</topic><topic>Stiffness</topic><topic>Testosterone - blood</topic><topic>Therapeutic applications</topic><topic>Vascular Stiffness</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogola, Benard O</creatorcontrib><creatorcontrib>Zimmerman, Margaret A</creatorcontrib><creatorcontrib>Clark, Gabrielle L</creatorcontrib><creatorcontrib>Abshire, Caleb M</creatorcontrib><creatorcontrib>Gentry, Kaylee M</creatorcontrib><creatorcontrib>Miller, Kristin S</creatorcontrib><creatorcontrib>Lindsey, Sarah H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogola, Benard O</au><au>Zimmerman, Margaret A</au><au>Clark, Gabrielle L</au><au>Abshire, Caleb M</au><au>Gentry, Kaylee M</au><au>Miller, Kristin S</au><au>Lindsey, Sarah H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New insights into arterial stiffening: does sex matter?</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>315</volume><issue>5</issue><spage>H1073</spage><epage>H1087</epage><pages>H1073-H1087</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><abstract>This review discusses sexual dimorphism in arterial stiffening, disease pathology interactions, and the influence of sex on mechanisms and pathways. Arterial stiffness predicts cardiovascular mortality independent of blood pressure. Patients with increased arterial stiffness have a 48% higher risk for developing cardiovascular disease. Like other cardiovascular pathologies, arterial stiffness is sexually dimorphic. Young women have lower stiffness than aged-matched men, but this sex difference reverses during normal aging. Estrogen therapy does not attenuate progressive stiffening in postmenopausal women, indicating that currently prescribed drugs do not confer protection. Although remodeling of large arteries is a protective adaptation to higher wall stress, arterial stiffening increases afterload to the left ventricle and transmits higher pulsatile pressure to smaller arteries and target organs. Moreover, an increase in aortic stiffness may precede or exacerbate hypertension, particularly during aging. Additional studies are needed to elucidate the mechanisms by which females are protected from arterial stiffness to provide insight into its mechanisms and, ultimately, therapeutic targets for treating this pathology.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>30028199</pmid><doi>10.1152/ajpheart.00132.2018</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Age Factors Aging Animals Aorta Arterial Pressure Arteries Arteries - drug effects Arteries - metabolism Arteries - physiopathology Blood pressure Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Cardiovascular Diseases - physiopathology Cardiovascular Diseases - prevention & control Cardiovascular system Disease Models, Animal Drug development Estrogen Replacement Therapy Estrogens Estrogens - blood Female Females Health risks Health Status Disparities Humans Hypertension Male Menopause Organs Pathology Post-menopause Protective Factors Review Risk Factors Sex Sex Characteristics Sex Factors Sexual dimorphism Stiffening Stiffness Testosterone - blood Therapeutic applications Vascular Stiffness Ventricle |
| title | New insights into arterial stiffening: does sex matter? |
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