New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications
Reactive electrospinning is capable of efficiently producing in situ crosslinked scaffolds resembling the natural extracellular matrix with tunable characteristics. In this study, we aimed to synthesize, characterize, and investigate the in vitro cytocompatibility of electrospun fibers of acrylated...
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| Veröffentlicht in: | Polymers 2018-04, Vol.10 (4), p.455 |
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| creator | Ismail, Hesham M Zamani, Somayeh Elrayess, Mohamed A Kafienah, Wael Younes, Husam M |
| description | Reactive electrospinning is capable of efficiently producing in situ crosslinked scaffolds resembling the natural extracellular matrix with tunable characteristics. In this study, we aimed to synthesize, characterize, and investigate the in vitro cytocompatibility of electrospun fibers of acrylated poly(1,10-decanediol-
-tricarballylate) copolymer prepared utilizing the photoreactive electrospinning process with ultraviolet radiation for crosslinking, to be used for cardiac tissue engineering applications. Chemical, thermal, and morphological characterization confirmed the successful synthesis of the polymer used for production of the electrospun fibrous scaffolds with more than 70% porosity. Mechanical testing confirmed the elastomeric nature of the fibers required to withstand cardiac contraction and relaxation. The cell viability assay showed no significant cytotoxicity of the fibers on cultured cardiomyoblasts and the cell-scaffolds interaction study showed a significant increase in cell attachment and growth on the electrospun fibers compared to the reference. This data suggests that the newly synthesized fibrous scaffold constitutes a promising candidate for cardiac tissue engineering applications. |
| doi_str_mv | 10.3390/polym10040455 |
| format | Article |
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-tricarballylate) copolymer prepared utilizing the photoreactive electrospinning process with ultraviolet radiation for crosslinking, to be used for cardiac tissue engineering applications. Chemical, thermal, and morphological characterization confirmed the successful synthesis of the polymer used for production of the electrospun fibrous scaffolds with more than 70% porosity. Mechanical testing confirmed the elastomeric nature of the fibers required to withstand cardiac contraction and relaxation. The cell viability assay showed no significant cytotoxicity of the fibers on cultured cardiomyoblasts and the cell-scaffolds interaction study showed a significant increase in cell attachment and growth on the electrospun fibers compared to the reference. This data suggests that the newly synthesized fibrous scaffold constitutes a promising candidate for cardiac tissue engineering applications.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym10040455</identifier><identifier>PMID: 30966490</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Biocompatibility ; Chemical synthesis ; Elastomers ; Electrospinning ; Fibers ; Mechanical tests ; Morphology ; Porosity ; Radiation crosslinking ; Scaffolds ; Thermodynamic properties ; Tissue engineering ; Toxicity ; Ultraviolet radiation</subject><ispartof>Polymers, 2018-04, Vol.10 (4), p.455</ispartof><rights>Copyright MDPI AG 2018</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-2e56fff7f23947dbcc748e02d24fb71bfe2f4c9e3019e3abbbc5eba32fcc7b233</citedby><cites>FETCH-LOGICAL-c415t-2e56fff7f23947dbcc748e02d24fb71bfe2f4c9e3019e3abbbc5eba32fcc7b233</cites><orcidid>0000-0002-0377-1658 ; 0000-0002-8191-4415 ; 0000-0003-1487-6823 ; 0000-0002-0708-9250 ; 0000-0003-3803-4604</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415264/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415264/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30966490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ismail, Hesham M</creatorcontrib><creatorcontrib>Zamani, Somayeh</creatorcontrib><creatorcontrib>Elrayess, Mohamed A</creatorcontrib><creatorcontrib>Kafienah, Wael</creatorcontrib><creatorcontrib>Younes, Husam M</creatorcontrib><title>New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications</title><title>Polymers</title><addtitle>Polymers (Basel)</addtitle><description>Reactive electrospinning is capable of efficiently producing in situ crosslinked scaffolds resembling the natural extracellular matrix with tunable characteristics. In this study, we aimed to synthesize, characterize, and investigate the in vitro cytocompatibility of electrospun fibers of acrylated poly(1,10-decanediol-
-tricarballylate) copolymer prepared utilizing the photoreactive electrospinning process with ultraviolet radiation for crosslinking, to be used for cardiac tissue engineering applications. Chemical, thermal, and morphological characterization confirmed the successful synthesis of the polymer used for production of the electrospun fibrous scaffolds with more than 70% porosity. Mechanical testing confirmed the elastomeric nature of the fibers required to withstand cardiac contraction and relaxation. The cell viability assay showed no significant cytotoxicity of the fibers on cultured cardiomyoblasts and the cell-scaffolds interaction study showed a significant increase in cell attachment and growth on the electrospun fibers compared to the reference. This data suggests that the newly synthesized fibrous scaffold constitutes a promising candidate for cardiac tissue engineering applications.</description><subject>Biocompatibility</subject><subject>Chemical synthesis</subject><subject>Elastomers</subject><subject>Electrospinning</subject><subject>Fibers</subject><subject>Mechanical tests</subject><subject>Morphology</subject><subject>Porosity</subject><subject>Radiation crosslinking</subject><subject>Scaffolds</subject><subject>Thermodynamic properties</subject><subject>Tissue engineering</subject><subject>Toxicity</subject><subject>Ultraviolet radiation</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdksFu3CAQhq2qVROlOfZaIfWSHtxgwPb6UinaZtNISZrD9mwBHnaJMLiAU-0r9Skzq6RRUg6AmI-fYf4pio8V_cp5R0-n4HZjRamgoq7fFIeMtrwUvKFvX-wPiuOU7igOUTdN1b4vDjjtmkZ09LD4ewN_yHobAcrvdgSfbPDSkVsUPhlASw-DDa7UoczRahmVdG7nZIYv5NzJlMMIeE5WVsUwJ3INaUtWUu3ZDANRO3K7DTlEkDrbe8BLoHMMabLeW78hJkSylHGwUpO1TWlGxG-sB5TF8Nk0ub0UZpU-FO-MdAmOn9aj4tfqfL38UV79vLhcnl2VWlR1LhnUjTGmNYx3oh2U1q1YAGUDE0a1lTLAjNAdcFrhJJVSugYlOTNIKsb5UfHtUXea1QiDBp-jdP0U7Sjjrg_S9q8j3m77TbjvG3yfNQIFTp4EYvg9Q8r9aJMG57CaWKSeoTVVvWjrBaKf_0PvwhzRAaTQ1bYWqIhU-UhprFyKYJ6TqWi_b4T-VSMg_-nlD57pf7bzB5TAtT0</recordid><startdate>20180419</startdate><enddate>20180419</enddate><creator>Ismail, Hesham M</creator><creator>Zamani, Somayeh</creator><creator>Elrayess, Mohamed A</creator><creator>Kafienah, Wael</creator><creator>Younes, Husam M</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0377-1658</orcidid><orcidid>https://orcid.org/0000-0002-8191-4415</orcidid><orcidid>https://orcid.org/0000-0003-1487-6823</orcidid><orcidid>https://orcid.org/0000-0002-0708-9250</orcidid><orcidid>https://orcid.org/0000-0003-3803-4604</orcidid></search><sort><creationdate>20180419</creationdate><title>New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications</title><author>Ismail, Hesham M ; Zamani, Somayeh ; Elrayess, Mohamed A ; Kafienah, Wael ; Younes, Husam M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-2e56fff7f23947dbcc748e02d24fb71bfe2f4c9e3019e3abbbc5eba32fcc7b233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biocompatibility</topic><topic>Chemical synthesis</topic><topic>Elastomers</topic><topic>Electrospinning</topic><topic>Fibers</topic><topic>Mechanical tests</topic><topic>Morphology</topic><topic>Porosity</topic><topic>Radiation crosslinking</topic><topic>Scaffolds</topic><topic>Thermodynamic properties</topic><topic>Tissue engineering</topic><topic>Toxicity</topic><topic>Ultraviolet radiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ismail, Hesham M</creatorcontrib><creatorcontrib>Zamani, Somayeh</creatorcontrib><creatorcontrib>Elrayess, Mohamed A</creatorcontrib><creatorcontrib>Kafienah, Wael</creatorcontrib><creatorcontrib>Younes, Husam M</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ismail, Hesham M</au><au>Zamani, Somayeh</au><au>Elrayess, Mohamed A</au><au>Kafienah, Wael</au><au>Younes, Husam M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications</atitle><jtitle>Polymers</jtitle><addtitle>Polymers (Basel)</addtitle><date>2018-04-19</date><risdate>2018</risdate><volume>10</volume><issue>4</issue><spage>455</spage><pages>455-</pages><issn>2073-4360</issn><eissn>2073-4360</eissn><abstract>Reactive electrospinning is capable of efficiently producing in situ crosslinked scaffolds resembling the natural extracellular matrix with tunable characteristics. In this study, we aimed to synthesize, characterize, and investigate the in vitro cytocompatibility of electrospun fibers of acrylated poly(1,10-decanediol-
-tricarballylate) copolymer prepared utilizing the photoreactive electrospinning process with ultraviolet radiation for crosslinking, to be used for cardiac tissue engineering applications. Chemical, thermal, and morphological characterization confirmed the successful synthesis of the polymer used for production of the electrospun fibrous scaffolds with more than 70% porosity. Mechanical testing confirmed the elastomeric nature of the fibers required to withstand cardiac contraction and relaxation. The cell viability assay showed no significant cytotoxicity of the fibers on cultured cardiomyoblasts and the cell-scaffolds interaction study showed a significant increase in cell attachment and growth on the electrospun fibers compared to the reference. This data suggests that the newly synthesized fibrous scaffold constitutes a promising candidate for cardiac tissue engineering applications.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30966490</pmid><doi>10.3390/polym10040455</doi><orcidid>https://orcid.org/0000-0002-0377-1658</orcidid><orcidid>https://orcid.org/0000-0002-8191-4415</orcidid><orcidid>https://orcid.org/0000-0003-1487-6823</orcidid><orcidid>https://orcid.org/0000-0002-0708-9250</orcidid><orcidid>https://orcid.org/0000-0003-3803-4604</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Biocompatibility Chemical synthesis Elastomers Electrospinning Fibers Mechanical tests Morphology Porosity Radiation crosslinking Scaffolds Thermodynamic properties Tissue engineering Toxicity Ultraviolet radiation |
| title | New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications |
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