Temperature-Responsive Polymer Microgel-Gold Nanorods Composite Particles: Physicochemical Characterization and Cytocompatibility
In this paper, we report an easy route for preparing new metal nanorod-polymer composites consisting of gold nanorods, Au NRs, and temperature responsive copolymer "microgel" particles. The microgel particles of ~200 nm in size, which contain carboxylic acid groups, were prepared by surfac...
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| Veröffentlicht in: | Polymers 2018-01, Vol.10 (1), p.99 |
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| creator | Khan, Aslam Khan, Tajdar Husain Ahamed, Maqusood El-Toni, Ahmed Mohamed Aldalbahi, Ali Alam, Javed Ahamad, Tansir |
| description | In this paper, we report an easy route for preparing new metal nanorod-polymer composites consisting of gold nanorods, Au NRs, and temperature responsive copolymer "microgel" particles. The microgel particles of ~200 nm in size, which contain carboxylic acid groups, were prepared by surfactant-free emulsion polymerization of a selected mixture made of
-isopropylacylamide and acrylic acid in the presence of a cross-linker
,
'-methylenebisacrylamide. The electrostatic interactions between the cationic cetyltrimethylammonium bromide (CTAB) stabilized Au NRs and anionic microgel particles were expected to occur in order to prepare stable Au NRs-microgel composite particles. The optical and structural characterization of the composite was achieved using UV-Vis spectroscopy, Field emission scanning electron microscopy (FESEM), Transmission electron microscopy (TEM) and dynamic light scattering (DLS). TEM image shows that Au NRs are attached on the surface of the microgel particles. Dynamic light scattering measurements prove that the composite particles are temperature responsive, which means the particles undergo a decrease in size as the temperature increases above its phase transition temperature. In vitro cytotoxicity of the composite materials were tested by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), Lactate dehydrogenase (LDH), and hemolysis assay, which showed non-toxicity (biocompatibility). |
| doi_str_mv | 10.3390/polym10010099 |
| format | Article |
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-isopropylacylamide and acrylic acid in the presence of a cross-linker
,
'-methylenebisacrylamide. The electrostatic interactions between the cationic cetyltrimethylammonium bromide (CTAB) stabilized Au NRs and anionic microgel particles were expected to occur in order to prepare stable Au NRs-microgel composite particles. The optical and structural characterization of the composite was achieved using UV-Vis spectroscopy, Field emission scanning electron microscopy (FESEM), Transmission electron microscopy (TEM) and dynamic light scattering (DLS). TEM image shows that Au NRs are attached on the surface of the microgel particles. Dynamic light scattering measurements prove that the composite particles are temperature responsive, which means the particles undergo a decrease in size as the temperature increases above its phase transition temperature. In vitro cytotoxicity of the composite materials were tested by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), Lactate dehydrogenase (LDH), and hemolysis assay, which showed non-toxicity (biocompatibility).</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym10010099</identifier><identifier>PMID: 30966134</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acrylic acid ; Biocompatibility ; Cetyltrimethylammonium bromide ; Composite materials ; Crosslinking ; Emulsion polymerization ; Field emission microscopy ; Gold ; Image transmission ; Lactate dehydrogenase ; Methylene bisacrylamide ; Nanorods ; Particulate composites ; Phase transitions ; Photon correlation spectroscopy ; Polymer matrix composites ; Scanning electron microscopy ; Structural analysis ; Toxicity ; Transition temperature ; Transmission electron microscopy</subject><ispartof>Polymers, 2018-01, Vol.10 (1), p.99</ispartof><rights>Copyright MDPI AG 2018</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-a7302f2bf755594f69cc7f96cd0b44af038d208f33062643a916a11627ffcdef3</citedby><cites>FETCH-LOGICAL-c415t-a7302f2bf755594f69cc7f96cd0b44af038d208f33062643a916a11627ffcdef3</cites><orcidid>0000-0002-7906-5653 ; 0000-0003-1644-2367</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414914/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414914/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30966134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, Aslam</creatorcontrib><creatorcontrib>Khan, Tajdar Husain</creatorcontrib><creatorcontrib>Ahamed, Maqusood</creatorcontrib><creatorcontrib>El-Toni, Ahmed Mohamed</creatorcontrib><creatorcontrib>Aldalbahi, Ali</creatorcontrib><creatorcontrib>Alam, Javed</creatorcontrib><creatorcontrib>Ahamad, Tansir</creatorcontrib><title>Temperature-Responsive Polymer Microgel-Gold Nanorods Composite Particles: Physicochemical Characterization and Cytocompatibility</title><title>Polymers</title><addtitle>Polymers (Basel)</addtitle><description>In this paper, we report an easy route for preparing new metal nanorod-polymer composites consisting of gold nanorods, Au NRs, and temperature responsive copolymer "microgel" particles. The microgel particles of ~200 nm in size, which contain carboxylic acid groups, were prepared by surfactant-free emulsion polymerization of a selected mixture made of
-isopropylacylamide and acrylic acid in the presence of a cross-linker
,
'-methylenebisacrylamide. The electrostatic interactions between the cationic cetyltrimethylammonium bromide (CTAB) stabilized Au NRs and anionic microgel particles were expected to occur in order to prepare stable Au NRs-microgel composite particles. The optical and structural characterization of the composite was achieved using UV-Vis spectroscopy, Field emission scanning electron microscopy (FESEM), Transmission electron microscopy (TEM) and dynamic light scattering (DLS). TEM image shows that Au NRs are attached on the surface of the microgel particles. Dynamic light scattering measurements prove that the composite particles are temperature responsive, which means the particles undergo a decrease in size as the temperature increases above its phase transition temperature. In vitro cytotoxicity of the composite materials were tested by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), Lactate dehydrogenase (LDH), and hemolysis assay, which showed non-toxicity (biocompatibility).</description><subject>Acrylic acid</subject><subject>Biocompatibility</subject><subject>Cetyltrimethylammonium bromide</subject><subject>Composite materials</subject><subject>Crosslinking</subject><subject>Emulsion polymerization</subject><subject>Field emission microscopy</subject><subject>Gold</subject><subject>Image transmission</subject><subject>Lactate dehydrogenase</subject><subject>Methylene bisacrylamide</subject><subject>Nanorods</subject><subject>Particulate composites</subject><subject>Phase transitions</subject><subject>Photon correlation spectroscopy</subject><subject>Polymer matrix composites</subject><subject>Scanning electron microscopy</subject><subject>Structural analysis</subject><subject>Toxicity</subject><subject>Transition temperature</subject><subject>Transmission electron microscopy</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkc1LHjEQxkNpqWI99loWvHjZNl-bfeOhIIvagl-InkPe7MQ3kt1sk6yw3vqfN-IH2jCQIfObh8w8CH0l-DtjEv-Ygl8GgnEJKT-gbYpbVnMm8Mc3-RbaTekOl8MbIUj7GW0xLEvG-Db6ew3DBFHnOUJ9BWkKY3L3UF0-KkOszpyJ4RZ8fRJ8X53rMcTQp6oLwxSSywXUMTvjIR1Ul5slORPMBgZntK-6jY7aZIjuQWcXxkqPfdUtOZjSXV7Wzru8fEGfrPYJdp_vHXRzfHTd_apPL05-d4enteGkybVuGaaWrm3bNI3kVkhjWiuF6fGac20xW_UUryxjWFDBmZZEaEIEba01PVi2g34-6U7zeoDewJij9mqKbtBxUUE79b4yuo26DfdKcMIl4UVg_1kghj8zpKwGlwx4r0cIc1K0bJyIlhBZ0L3_0Lswx7GMpyjGdNU0HLNC1U9UWXFKEezrZwhWj_6qd_4W_tvbCV7pFzfZPyKXpRw</recordid><startdate>20180120</startdate><enddate>20180120</enddate><creator>Khan, Aslam</creator><creator>Khan, Tajdar Husain</creator><creator>Ahamed, Maqusood</creator><creator>El-Toni, Ahmed Mohamed</creator><creator>Aldalbahi, Ali</creator><creator>Alam, Javed</creator><creator>Ahamad, Tansir</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7906-5653</orcidid><orcidid>https://orcid.org/0000-0003-1644-2367</orcidid></search><sort><creationdate>20180120</creationdate><title>Temperature-Responsive Polymer Microgel-Gold Nanorods Composite Particles: Physicochemical Characterization and Cytocompatibility</title><author>Khan, Aslam ; Khan, Tajdar Husain ; Ahamed, Maqusood ; El-Toni, Ahmed Mohamed ; Aldalbahi, Ali ; Alam, Javed ; Ahamad, Tansir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-a7302f2bf755594f69cc7f96cd0b44af038d208f33062643a916a11627ffcdef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acrylic acid</topic><topic>Biocompatibility</topic><topic>Cetyltrimethylammonium bromide</topic><topic>Composite materials</topic><topic>Crosslinking</topic><topic>Emulsion polymerization</topic><topic>Field emission microscopy</topic><topic>Gold</topic><topic>Image transmission</topic><topic>Lactate dehydrogenase</topic><topic>Methylene bisacrylamide</topic><topic>Nanorods</topic><topic>Particulate composites</topic><topic>Phase transitions</topic><topic>Photon correlation spectroscopy</topic><topic>Polymer matrix composites</topic><topic>Scanning electron microscopy</topic><topic>Structural analysis</topic><topic>Toxicity</topic><topic>Transition temperature</topic><topic>Transmission electron microscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Aslam</creatorcontrib><creatorcontrib>Khan, Tajdar Husain</creatorcontrib><creatorcontrib>Ahamed, Maqusood</creatorcontrib><creatorcontrib>El-Toni, Ahmed Mohamed</creatorcontrib><creatorcontrib>Aldalbahi, Ali</creatorcontrib><creatorcontrib>Alam, Javed</creatorcontrib><creatorcontrib>Ahamad, Tansir</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Aslam</au><au>Khan, Tajdar Husain</au><au>Ahamed, Maqusood</au><au>El-Toni, Ahmed Mohamed</au><au>Aldalbahi, Ali</au><au>Alam, Javed</au><au>Ahamad, Tansir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temperature-Responsive Polymer Microgel-Gold Nanorods Composite Particles: Physicochemical Characterization and Cytocompatibility</atitle><jtitle>Polymers</jtitle><addtitle>Polymers (Basel)</addtitle><date>2018-01-20</date><risdate>2018</risdate><volume>10</volume><issue>1</issue><spage>99</spage><pages>99-</pages><issn>2073-4360</issn><eissn>2073-4360</eissn><abstract>In this paper, we report an easy route for preparing new metal nanorod-polymer composites consisting of gold nanorods, Au NRs, and temperature responsive copolymer "microgel" particles. The microgel particles of ~200 nm in size, which contain carboxylic acid groups, were prepared by surfactant-free emulsion polymerization of a selected mixture made of
-isopropylacylamide and acrylic acid in the presence of a cross-linker
,
'-methylenebisacrylamide. The electrostatic interactions between the cationic cetyltrimethylammonium bromide (CTAB) stabilized Au NRs and anionic microgel particles were expected to occur in order to prepare stable Au NRs-microgel composite particles. The optical and structural characterization of the composite was achieved using UV-Vis spectroscopy, Field emission scanning electron microscopy (FESEM), Transmission electron microscopy (TEM) and dynamic light scattering (DLS). TEM image shows that Au NRs are attached on the surface of the microgel particles. Dynamic light scattering measurements prove that the composite particles are temperature responsive, which means the particles undergo a decrease in size as the temperature increases above its phase transition temperature. In vitro cytotoxicity of the composite materials were tested by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), Lactate dehydrogenase (LDH), and hemolysis assay, which showed non-toxicity (biocompatibility).</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30966134</pmid><doi>10.3390/polym10010099</doi><orcidid>https://orcid.org/0000-0002-7906-5653</orcidid><orcidid>https://orcid.org/0000-0003-1644-2367</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Polymers, 2018-01, Vol.10 (1), p.99 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Acrylic acid Biocompatibility Cetyltrimethylammonium bromide Composite materials Crosslinking Emulsion polymerization Field emission microscopy Gold Image transmission Lactate dehydrogenase Methylene bisacrylamide Nanorods Particulate composites Phase transitions Photon correlation spectroscopy Polymer matrix composites Scanning electron microscopy Structural analysis Toxicity Transition temperature Transmission electron microscopy |
| title | Temperature-Responsive Polymer Microgel-Gold Nanorods Composite Particles: Physicochemical Characterization and Cytocompatibility |
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