PNIPAM-MAPOSS Hybrid Hydrogels with Excellent Swelling Behavior and Enhanced Mechanical Performance: Preparation and Drug Release of 5-Fluorouracil
Poly( -isopropylacrylamide) (PNIPAM) is a widely-studied polymers due to its excellent temperature sensitivity. PNIPAM-MAPOSS hybrid hydrogel, based on the introduction of acrylolsobutyl polyhedral oligomeric silsesquioxane (MAPOSS) into the PNIPAM matrix in the presence of polyethylene glycol, was...
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| Veröffentlicht in: | Polymers 2018-01, Vol.10 (2), p.137 |
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| creator | Li, Peihong Hou, Xiaoman Qu, Lijie Dai, Xueyan Zhang, Chunling |
| description | Poly(
-isopropylacrylamide) (PNIPAM) is a widely-studied polymers due to its excellent temperature sensitivity. PNIPAM-MAPOSS hybrid hydrogel, based on the introduction of acrylolsobutyl polyhedral oligomeric silsesquioxane (MAPOSS) into the PNIPAM matrix in the presence of polyethylene glycol, was prepared via radical polymerization. The modified hydrogels exhibited a thick, heterogeneous porous structure. PEG was used as a pore-forming agent to adjust the pore size. MAPOSS reduced the swelling ratios of gels, and decreased the LCST, causing the hydrogels to shrink at lower temperatures. However, its hydrophobicity helped to improve the temperature response rate. The incorporation of rigid MAPOSS into the polymer network greatly increased the compressive modulus of the hydrogel. It is worth noting that, by adjusting the amount of MAPOSS and PEG, the hydrogel could have both ideal mechanical properties and swelling behavior. In addition, hydrogel containing 8.33 wt % MAPOSS could achieve stable and sustained drug release. Thus, the prepared PNIPAM-MAPOSS hybrid hydrogel can serve as drug carrier for 5-fluorouracil and may have potential application in other biomedical fields. |
| doi_str_mv | 10.3390/polym10020137 |
| format | Article |
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-isopropylacrylamide) (PNIPAM) is a widely-studied polymers due to its excellent temperature sensitivity. PNIPAM-MAPOSS hybrid hydrogel, based on the introduction of acrylolsobutyl polyhedral oligomeric silsesquioxane (MAPOSS) into the PNIPAM matrix in the presence of polyethylene glycol, was prepared via radical polymerization. The modified hydrogels exhibited a thick, heterogeneous porous structure. PEG was used as a pore-forming agent to adjust the pore size. MAPOSS reduced the swelling ratios of gels, and decreased the LCST, causing the hydrogels to shrink at lower temperatures. However, its hydrophobicity helped to improve the temperature response rate. The incorporation of rigid MAPOSS into the polymer network greatly increased the compressive modulus of the hydrogel. It is worth noting that, by adjusting the amount of MAPOSS and PEG, the hydrogel could have both ideal mechanical properties and swelling behavior. In addition, hydrogel containing 8.33 wt % MAPOSS could achieve stable and sustained drug release. Thus, the prepared PNIPAM-MAPOSS hybrid hydrogel can serve as drug carrier for 5-fluorouracil and may have potential application in other biomedical fields.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym10020137</identifier><identifier>PMID: 30966173</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Drug carriers ; Drug delivery systems ; Gels ; Hydrogels ; Hydrophobicity ; Isopropylacrylamide ; Mechanical properties ; Modulus of elasticity ; Polyethylene glycol ; Polyhedral oligomeric silsesquioxane ; Pore formation ; Pore size ; Porosity ; Swelling</subject><ispartof>Polymers, 2018-01, Vol.10 (2), p.137</ispartof><rights>Copyright MDPI AG 2018</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-137eeb3920fd964802a82a58d9c148a280011d1f79347748832ee92f987e8d073</citedby><cites>FETCH-LOGICAL-c415t-137eeb3920fd964802a82a58d9c148a280011d1f79347748832ee92f987e8d073</cites><orcidid>0000-0002-8981-3184</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414838/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414838/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30966173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Peihong</creatorcontrib><creatorcontrib>Hou, Xiaoman</creatorcontrib><creatorcontrib>Qu, Lijie</creatorcontrib><creatorcontrib>Dai, Xueyan</creatorcontrib><creatorcontrib>Zhang, Chunling</creatorcontrib><title>PNIPAM-MAPOSS Hybrid Hydrogels with Excellent Swelling Behavior and Enhanced Mechanical Performance: Preparation and Drug Release of 5-Fluorouracil</title><title>Polymers</title><addtitle>Polymers (Basel)</addtitle><description>Poly(
-isopropylacrylamide) (PNIPAM) is a widely-studied polymers due to its excellent temperature sensitivity. PNIPAM-MAPOSS hybrid hydrogel, based on the introduction of acrylolsobutyl polyhedral oligomeric silsesquioxane (MAPOSS) into the PNIPAM matrix in the presence of polyethylene glycol, was prepared via radical polymerization. The modified hydrogels exhibited a thick, heterogeneous porous structure. PEG was used as a pore-forming agent to adjust the pore size. MAPOSS reduced the swelling ratios of gels, and decreased the LCST, causing the hydrogels to shrink at lower temperatures. However, its hydrophobicity helped to improve the temperature response rate. The incorporation of rigid MAPOSS into the polymer network greatly increased the compressive modulus of the hydrogel. It is worth noting that, by adjusting the amount of MAPOSS and PEG, the hydrogel could have both ideal mechanical properties and swelling behavior. In addition, hydrogel containing 8.33 wt % MAPOSS could achieve stable and sustained drug release. Thus, the prepared PNIPAM-MAPOSS hybrid hydrogel can serve as drug carrier for 5-fluorouracil and may have potential application in other biomedical fields.</description><subject>Drug carriers</subject><subject>Drug delivery systems</subject><subject>Gels</subject><subject>Hydrogels</subject><subject>Hydrophobicity</subject><subject>Isopropylacrylamide</subject><subject>Mechanical properties</subject><subject>Modulus of elasticity</subject><subject>Polyethylene glycol</subject><subject>Polyhedral oligomeric silsesquioxane</subject><subject>Pore formation</subject><subject>Pore size</subject><subject>Porosity</subject><subject>Swelling</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdUU1v1DAUjBCIVqVHrsgSFy6h_krscEBayvZD6rYRC2fL67zsunLirZ207O_gD-PQUrX15Y3s8bw3b7LsPcGfGavw0da7XUcwppgw8Srbp1iwnLMSv36C97LDGK9xOrwoSyLeZnsMVxNi-9mf-vK8ni3yxay-Wi7R2W4VbJNKE_waXER3dtig-W8DzkE_oOVdArZfo2-w0bfWB6T7Bs37je4NNGgBJiFrtEM1hNaHbrr_guoAWx30YH3_78P3MK7RD3CgIyDfoiI_caMPfgzaWPcue9NqF-HwoR5kv07mP4_P8our0_Pj2UVuOCmGPFkGWLGK4rapSi4x1ZLqQjaVIVxqKjEmpCGtqBgXgkvJKEBF20oKkE3azkH29V53O646aEwyGLRT22A7HXbKa6uev_R2o9b-VpU8NWAyCXx6EAj-ZoQ4qM7GaVW6Bz9GRVMGROCUQaJ-fEG9Tm77ZE-l8LigXBbTRPk9ywQfY4D2cRiC1ZS4epZ44n946uCR_T9f9hfTSqdP</recordid><startdate>20180131</startdate><enddate>20180131</enddate><creator>Li, Peihong</creator><creator>Hou, Xiaoman</creator><creator>Qu, Lijie</creator><creator>Dai, Xueyan</creator><creator>Zhang, Chunling</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8981-3184</orcidid></search><sort><creationdate>20180131</creationdate><title>PNIPAM-MAPOSS Hybrid Hydrogels with Excellent Swelling Behavior and Enhanced Mechanical Performance: Preparation and Drug Release of 5-Fluorouracil</title><author>Li, Peihong ; Hou, Xiaoman ; Qu, Lijie ; Dai, Xueyan ; Zhang, Chunling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-137eeb3920fd964802a82a58d9c148a280011d1f79347748832ee92f987e8d073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Drug carriers</topic><topic>Drug delivery systems</topic><topic>Gels</topic><topic>Hydrogels</topic><topic>Hydrophobicity</topic><topic>Isopropylacrylamide</topic><topic>Mechanical properties</topic><topic>Modulus of elasticity</topic><topic>Polyethylene glycol</topic><topic>Polyhedral oligomeric silsesquioxane</topic><topic>Pore formation</topic><topic>Pore size</topic><topic>Porosity</topic><topic>Swelling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Peihong</creatorcontrib><creatorcontrib>Hou, Xiaoman</creatorcontrib><creatorcontrib>Qu, Lijie</creatorcontrib><creatorcontrib>Dai, Xueyan</creatorcontrib><creatorcontrib>Zhang, Chunling</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Peihong</au><au>Hou, Xiaoman</au><au>Qu, Lijie</au><au>Dai, Xueyan</au><au>Zhang, Chunling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PNIPAM-MAPOSS Hybrid Hydrogels with Excellent Swelling Behavior and Enhanced Mechanical Performance: Preparation and Drug Release of 5-Fluorouracil</atitle><jtitle>Polymers</jtitle><addtitle>Polymers (Basel)</addtitle><date>2018-01-31</date><risdate>2018</risdate><volume>10</volume><issue>2</issue><spage>137</spage><pages>137-</pages><issn>2073-4360</issn><eissn>2073-4360</eissn><abstract>Poly(
-isopropylacrylamide) (PNIPAM) is a widely-studied polymers due to its excellent temperature sensitivity. PNIPAM-MAPOSS hybrid hydrogel, based on the introduction of acrylolsobutyl polyhedral oligomeric silsesquioxane (MAPOSS) into the PNIPAM matrix in the presence of polyethylene glycol, was prepared via radical polymerization. The modified hydrogels exhibited a thick, heterogeneous porous structure. PEG was used as a pore-forming agent to adjust the pore size. MAPOSS reduced the swelling ratios of gels, and decreased the LCST, causing the hydrogels to shrink at lower temperatures. However, its hydrophobicity helped to improve the temperature response rate. The incorporation of rigid MAPOSS into the polymer network greatly increased the compressive modulus of the hydrogel. It is worth noting that, by adjusting the amount of MAPOSS and PEG, the hydrogel could have both ideal mechanical properties and swelling behavior. In addition, hydrogel containing 8.33 wt % MAPOSS could achieve stable and sustained drug release. Thus, the prepared PNIPAM-MAPOSS hybrid hydrogel can serve as drug carrier for 5-fluorouracil and may have potential application in other biomedical fields.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30966173</pmid><doi>10.3390/polym10020137</doi><orcidid>https://orcid.org/0000-0002-8981-3184</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Drug carriers Drug delivery systems Gels Hydrogels Hydrophobicity Isopropylacrylamide Mechanical properties Modulus of elasticity Polyethylene glycol Polyhedral oligomeric silsesquioxane Pore formation Pore size Porosity Swelling |
| title | PNIPAM-MAPOSS Hybrid Hydrogels with Excellent Swelling Behavior and Enhanced Mechanical Performance: Preparation and Drug Release of 5-Fluorouracil |
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