Salidroside protects PC-12 cells against amyloid β-induced apoptosis by activation of the ERK1/2 and AKT signaling pathways

Alzheimer's disease (AD) is one of the most frequent diseases in elderly people and causes high mortality. Its incidence is increasing annually and no effective therapeutic treatment currently exists. In the present study, salidroside, a major active ingredient of Rhodiola rosea, was able to pr...

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Veröffentlicht in:	International journal of molecular medicine 2019-04, Vol.43 (4), p.1769-1777
Hauptverfasser:	Liao, Zheng-Luan, Su, Heng, Tan, Yun-Fei, Qiu, Ya-Ju, Zhu, Jun-Peng, Chen, Yan, Lin, Si-Si, Wu, Ming-Hao, Mao, Yan-Ping, Hu, Jiao-Jiao, Yu, En-Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - toxicity Animals Apoptosis Apoptosis - drug effects Caspase 3 - metabolism Caspase 7 - metabolism Cytoprotection - drug effects Cytotoxicity Disease Drug development Glucosides - chemistry Glucosides - pharmacology Kinases L-Lactate Dehydrogenase - metabolism Malondialdehyde - metabolism MAP Kinase Signaling System - drug effects Membrane Potential, Mitochondrial - drug effects Mitochondria - drug effects Mitochondria - metabolism Mutation Neuroprotective Agents - pharmacology Oxidative stress PC12 Cells Phenols - chemistry Phenols - pharmacology Phosphorylation Phosphorylation - drug effects Physiology Proteins Proto-Oncogene Proteins c-akt - metabolism Rats Reactive Oxygen Species - metabolism Superoxide Dismutase - metabolism
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