Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases

The design of selective matrix metalloproteinase (MMP) inhibitors that also possess favorable solubility properties has proved to be especially challenging. A prior approach using collagen-model templates combined with transition state analogs produced a first generation of triple-helical peptide in...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2017-05, Vol.60 (9), p.3814-3827
Hauptverfasser:	Bhowmick, Manishabrata, Tokmina-Roszyk, Dorota, Onwuha-Ekpete, Lillian, Harmon, Kelli, Robichaud, Trista, Fuerst, Rita, Stawikowska, Roma, Steffensen, Bjorn, Roush, William, Wong, Hector R, Fields, Gregg B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - drug therapy Humans Matrix Metalloproteinases - drug effects Multiple Sclerosis - drug therapy Peptides - chemistry Peptides - pharmacology Peptides - therapeutic use Protease Inhibitors - pharmacology Protease Inhibitors - therapeutic use Sepsis - drug therapy Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!