The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling

Quetiapine, one of the most prescribed atypical antipsychotics, has been associated with hyperlipidemia and an increased risk for cardiovascular disease in patients, but the underlying mechanisms remain unknown. Here, we identified quetiapine as a potent and selective agonist for pregnane X receptor...

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Veröffentlicht in:	JCI insight 2019-02, Vol.4 (3)
Hauptverfasser:	Meng, Zhaojie, Gwag, Taesik, Sui, Yipeng, Park, Se-Hyung, Zhou, Xiangping, Zhou, Changcheng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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