Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake
Exposure to aristolochic acids (AAs) from Aristolochia plants is one of the major global causes of nephropathy, including Balkan endemic nephropathy (BEN); renal failure; and urothelial cancer. The high incidence of BEN on the Balkan Peninsula is assumed to result from consumption of Aristolochia cl...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2018-10, Vol.66 (43), p.11468-11476 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Li, Weiwei Chan, Chi-Kong Liu, Yushuo Yao, Jing Mitić, Branka Kostić, Emina N Milosavljević, Biljana Davinić, Ivana Orem, William H Tatu, Calin A Dedon, Peter C Pavlović, Nikola M Chan, Wan |
| description | Exposure to aristolochic acids (AAs) from Aristolochia plants is one of the major global causes of nephropathy, including Balkan endemic nephropathy (BEN); renal failure; and urothelial cancer. The high incidence of BEN on the Balkan Peninsula is assumed to result from consumption of Aristolochia clematitis L. seeds coharvested with crops. Here, we show that AAs are long-lived soil contaminants that enter wheat and maize plants by root uptake with strong pH dependence. Soil and crops from Serbian farms in areas endemic for A. clematitis were found to be extensively contaminated with AAs, with contamination strongly correlated with local incidence of BEN. The persistence of AAs as soil contaminants suggests that weed control for A. clematitis plants is needed to reduce the incidence of BEN and aristolochic acid nephropathy, systematic surveys of soil and crop AA levels would identify high-risk regions, and it is imperative to research soil-remediation methods. |
| doi_str_mv | 10.1021/acs.jafc.8b04770 |
| format | Article |
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The high incidence of BEN on the Balkan Peninsula is assumed to result from consumption of Aristolochia clematitis L. seeds coharvested with crops. Here, we show that AAs are long-lived soil contaminants that enter wheat and maize plants by root uptake with strong pH dependence. Soil and crops from Serbian farms in areas endemic for A. clematitis were found to be extensively contaminated with AAs, with contamination strongly correlated with local incidence of BEN. The persistence of AAs as soil contaminants suggests that weed control for A. clematitis plants is needed to reduce the incidence of BEN and aristolochic acid nephropathy, systematic surveys of soil and crop AA levels would identify high-risk regions, and it is imperative to research soil-remediation methods.</description><identifier>ISSN: 0021-8561</identifier><identifier>ISSN: 1520-5118</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/acs.jafc.8b04770</identifier><identifier>PMID: 30286603</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Aristolochia ; aristolochic acids ; Aristolochic Acids - adverse effects ; Balkan endemic nephropathy ; corn ; crops ; Dietary Exposure - adverse effects ; farms ; Humans ; Kidney Diseases - chemically induced ; Kidney Diseases - epidemiology ; Molecular Structure ; neoplasms ; Plant Roots - chemistry ; renal failure ; risk ; Serbia - epidemiology ; soil ; Soil Pollutants - adverse effects ; soil pollution ; soil remediation ; surveys ; Triticum - chemistry ; weed control ; wheat ; Zea mays - chemistry</subject><ispartof>Journal of agricultural and food chemistry, 2018-10, Vol.66 (43), p.11468-11476</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a466t-f12a4273726986ec3c649c467f5f05e3abca593c0b3a7b37976cb1e1093594073</citedby><cites>FETCH-LOGICAL-a466t-f12a4273726986ec3c649c467f5f05e3abca593c0b3a7b37976cb1e1093594073</cites><orcidid>0000-0003-0011-3067 ; 0000-0001-7963-8725 ; 0000-0001-8479-3172</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.jafc.8b04770$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.jafc.8b04770$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,776,780,881,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30286603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Weiwei</creatorcontrib><creatorcontrib>Chan, Chi-Kong</creatorcontrib><creatorcontrib>Liu, Yushuo</creatorcontrib><creatorcontrib>Yao, Jing</creatorcontrib><creatorcontrib>Mitić, Branka</creatorcontrib><creatorcontrib>Kostić, Emina N</creatorcontrib><creatorcontrib>Milosavljević, Biljana</creatorcontrib><creatorcontrib>Davinić, Ivana</creatorcontrib><creatorcontrib>Orem, William H</creatorcontrib><creatorcontrib>Tatu, Calin A</creatorcontrib><creatorcontrib>Dedon, Peter C</creatorcontrib><creatorcontrib>Pavlović, Nikola M</creatorcontrib><creatorcontrib>Chan, Wan</creatorcontrib><title>Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Exposure to aristolochic acids (AAs) from Aristolochia plants is one of the major global causes of nephropathy, including Balkan endemic nephropathy (BEN); renal failure; and urothelial cancer. The high incidence of BEN on the Balkan Peninsula is assumed to result from consumption of Aristolochia clematitis L. seeds coharvested with crops. Here, we show that AAs are long-lived soil contaminants that enter wheat and maize plants by root uptake with strong pH dependence. Soil and crops from Serbian farms in areas endemic for A. clematitis were found to be extensively contaminated with AAs, with contamination strongly correlated with local incidence of BEN. The persistence of AAs as soil contaminants suggests that weed control for A. clematitis plants is needed to reduce the incidence of BEN and aristolochic acid nephropathy, systematic surveys of soil and crop AA levels would identify high-risk regions, and it is imperative to research soil-remediation methods.</description><subject>Aristolochia</subject><subject>aristolochic acids</subject><subject>Aristolochic Acids - adverse effects</subject><subject>Balkan endemic nephropathy</subject><subject>corn</subject><subject>crops</subject><subject>Dietary Exposure - adverse effects</subject><subject>farms</subject><subject>Humans</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - epidemiology</subject><subject>Molecular Structure</subject><subject>neoplasms</subject><subject>Plant Roots - chemistry</subject><subject>renal failure</subject><subject>risk</subject><subject>Serbia - epidemiology</subject><subject>soil</subject><subject>Soil Pollutants - adverse effects</subject><subject>soil pollution</subject><subject>soil remediation</subject><subject>surveys</subject><subject>Triticum - chemistry</subject><subject>weed control</subject><subject>wheat</subject><subject>Zea mays - chemistry</subject><issn>0021-8561</issn><issn>1520-5118</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1v1DAQxS1ERZfCnRPykQNZxt8JB6RVKRSpKiugZ8vxOqzbJE5tB1GJPx6X3Vb0gMTJ0vj3nubNQ-gFgSUBSt4Ym5aXprPLugWuFDxCCyIoVIKQ-jFaQGGqWkhyiJ6mdAkAtVDwBB0yoLWUwBbo1yr6lEMf7NZbvLJ-k7BJeO1iKnM3Zvw1-B6vQ9_P2Yw5vcXvXXZx8KPJPow4dPiLT1e4CxGfzoMZ8cnPKaQ5OmzGDT530zaGyeTtDe5iGPC6Ly74Ysrmyj1DB53pk3u-f4_QxYeTb8en1dnnj5-OV2eV4VLmqiPUcKqYorKppbPMSt5YLlUnOhCOmdYa0TALLTOqZapR0rbEEWiYaDgodoTe7XynuR3cxpZY0fR6in4w8UYH4_XDn9Fv9ffwQ0tOmGxoMXi1N4jhenYp68En6_qSxYU5aUrqRnAJVPwHSmQtCAdZUNihNoaUouvuNyKgb_vVpV9926_e91skL_9Oci-4K7QAr3fAH2mY41gO-2-_3ynqszE</recordid><startdate>20181031</startdate><enddate>20181031</enddate><creator>Li, Weiwei</creator><creator>Chan, Chi-Kong</creator><creator>Liu, Yushuo</creator><creator>Yao, Jing</creator><creator>Mitić, Branka</creator><creator>Kostić, Emina N</creator><creator>Milosavljević, Biljana</creator><creator>Davinić, Ivana</creator><creator>Orem, William H</creator><creator>Tatu, Calin A</creator><creator>Dedon, Peter C</creator><creator>Pavlović, Nikola M</creator><creator>Chan, Wan</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0011-3067</orcidid><orcidid>https://orcid.org/0000-0001-7963-8725</orcidid><orcidid>https://orcid.org/0000-0001-8479-3172</orcidid></search><sort><creationdate>20181031</creationdate><title>Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake</title><author>Li, Weiwei ; Chan, Chi-Kong ; Liu, Yushuo ; Yao, Jing ; Mitić, Branka ; Kostić, Emina N ; Milosavljević, Biljana ; Davinić, Ivana ; Orem, William H ; Tatu, Calin A ; Dedon, Peter C ; Pavlović, Nikola M ; Chan, Wan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a466t-f12a4273726986ec3c649c467f5f05e3abca593c0b3a7b37976cb1e1093594073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aristolochia</topic><topic>aristolochic acids</topic><topic>Aristolochic Acids - adverse effects</topic><topic>Balkan endemic nephropathy</topic><topic>corn</topic><topic>crops</topic><topic>Dietary Exposure - adverse effects</topic><topic>farms</topic><topic>Humans</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - epidemiology</topic><topic>Molecular Structure</topic><topic>neoplasms</topic><topic>Plant Roots - chemistry</topic><topic>renal failure</topic><topic>risk</topic><topic>Serbia - epidemiology</topic><topic>soil</topic><topic>Soil Pollutants - adverse effects</topic><topic>soil pollution</topic><topic>soil remediation</topic><topic>surveys</topic><topic>Triticum - chemistry</topic><topic>weed control</topic><topic>wheat</topic><topic>Zea mays - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Weiwei</creatorcontrib><creatorcontrib>Chan, Chi-Kong</creatorcontrib><creatorcontrib>Liu, Yushuo</creatorcontrib><creatorcontrib>Yao, Jing</creatorcontrib><creatorcontrib>Mitić, Branka</creatorcontrib><creatorcontrib>Kostić, Emina N</creatorcontrib><creatorcontrib>Milosavljević, Biljana</creatorcontrib><creatorcontrib>Davinić, Ivana</creatorcontrib><creatorcontrib>Orem, William H</creatorcontrib><creatorcontrib>Tatu, Calin A</creatorcontrib><creatorcontrib>Dedon, Peter C</creatorcontrib><creatorcontrib>Pavlović, Nikola M</creatorcontrib><creatorcontrib>Chan, Wan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Weiwei</au><au>Chan, Chi-Kong</au><au>Liu, Yushuo</au><au>Yao, Jing</au><au>Mitić, Branka</au><au>Kostić, Emina N</au><au>Milosavljević, Biljana</au><au>Davinić, Ivana</au><au>Orem, William H</au><au>Tatu, Calin A</au><au>Dedon, Peter C</au><au>Pavlović, Nikola M</au><au>Chan, Wan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2018-10-31</date><risdate>2018</risdate><volume>66</volume><issue>43</issue><spage>11468</spage><epage>11476</epage><pages>11468-11476</pages><issn>0021-8561</issn><issn>1520-5118</issn><eissn>1520-5118</eissn><abstract>Exposure to aristolochic acids (AAs) from Aristolochia plants is one of the major global causes of nephropathy, including Balkan endemic nephropathy (BEN); renal failure; and urothelial cancer. The high incidence of BEN on the Balkan Peninsula is assumed to result from consumption of Aristolochia clematitis L. seeds coharvested with crops. Here, we show that AAs are long-lived soil contaminants that enter wheat and maize plants by root uptake with strong pH dependence. Soil and crops from Serbian farms in areas endemic for A. clematitis were found to be extensively contaminated with AAs, with contamination strongly correlated with local incidence of BEN. The persistence of AAs as soil contaminants suggests that weed control for A. clematitis plants is needed to reduce the incidence of BEN and aristolochic acid nephropathy, systematic surveys of soil and crop AA levels would identify high-risk regions, and it is imperative to research soil-remediation methods.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>30286603</pmid><doi>10.1021/acs.jafc.8b04770</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0011-3067</orcidid><orcidid>https://orcid.org/0000-0001-7963-8725</orcidid><orcidid>https://orcid.org/0000-0001-8479-3172</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-8561 |
| ispartof | Journal of agricultural and food chemistry, 2018-10, Vol.66 (43), p.11468-11476 |
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| source | ACS Publications; MEDLINE |
| subjects | Aristolochia aristolochic acids Aristolochic Acids - adverse effects Balkan endemic nephropathy corn crops Dietary Exposure - adverse effects farms Humans Kidney Diseases - chemically induced Kidney Diseases - epidemiology Molecular Structure neoplasms Plant Roots - chemistry renal failure risk Serbia - epidemiology soil Soil Pollutants - adverse effects soil pollution soil remediation surveys Triticum - chemistry weed control wheat Zea mays - chemistry |
| title | Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake |
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