The TrkB‐T1 receptor mediates BDNF‐induced migration of aged cardiac microvascular endothelial cells by recruiting Willin

The mechanism of age‐related decline in the angiogenic potential of the myocardium is not yet fully understood. Our previous report revealed that the aging of cardiac microvascular endothelial cells (CMECs) led to changes in their expression of receptor Trk isoforms: among the three isoforms (TrkB‐F...

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Veröffentlicht in:	Aging cell 2019-04, Vol.18 (2), p.e12881-n/a
Hauptverfasser:	Wang, Zhefeng, Chen, Yilin, Chen, Xuwei, Zheng, Xin, Xu, Ganlin, Yuan, Ziqiang, Zhao, Hui, Chen, Wensheng, Li, Lilin, Zheng, Nianjue, Shen, Xiaotao, Li, Yanmei, Qi, Xufeng, Cai, Dongqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Angiogenesis Animals BDNF–TrkB Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism cardiac microvascular endothelial cell aging Cell Movement Cells, Cultured Cellular Senescence Endothelial cells Endothelial Cells - cytology Endothelial Cells - metabolism Endothelium HEK293 Cells Hippo pathway Humans Intracellular Signaling Peptides and Proteins - metabolism Isoforms Microvasculature migration Myocardium Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Neovascularization, Physiologic Nitric oxide Original Phenotypes Rats Receptor, trkB - genetics Receptor, trkB - metabolism Signal Transduction Therapeutic applications TrkB receptors Willin/FRMD6
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