A core-weighted fitting method for docking atomic structures into low-resolution maps: Application to cryo-electron microscopy

Cryo-electron microscopy of “single particles” is a powerful method to analyze structures of large macromolecular assemblies that are not amenable to investigation by traditional X-ray crystallographic methods. A key step in these studies is to obtain atomic interpretations of multiprotein complexes...

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Veröffentlicht in:	Journal of structural biology 2003-01, Vol.141 (1), p.63-76
Hauptverfasser:	Wu, Xiongwu, Milne, Jacqueline L.S., Borgnia, Mario J., Rostapshov, Alexey V., Subramaniam, Sriram, Brooks, Bernard R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalytic Domain Conformational search Correlation function Cryo-electron microscopy Cryoelectron Microscopy - methods Crystallography, X-Ray - methods Docking Ketone Oxidoreductases - chemistry Microscopy, Electron Models, Molecular Models, Statistical Monte Carlo Monte Carlo Method Multiprotein complex Protein Binding Protein Conformation Protein Structure, Tertiary Receptors, Antigen, T-Cell - chemistry Single-particle microscopy Statistics as Topic - methods
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